Immune

On this episode of Immune, the team explores two fortuitous discoveries: caspase inhibitors that hitch a ride through gasdermin D pores to selectively shut down proinflammatory cytokine secretion, and human monoclonal antibodies against malaria that were repurposed to block allergic antibody binding to red meat allergens in alpha-gal syndrome.
Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker

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GasderminD pores deliver drugs (Nature, 2026)
Potential alpha-gal syndrome treatment (J Clin Immunol, 2026)
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.

Tulika Singh joins Immune at AAI2026 to talk about the international partnerships that advance research on immunity to emerging flaviviruses and her research on the impact of prior Zika virus infection on susceptibility to Dengue virus disease.


Host: Cindy Leifer
Guest: Tulika Singh
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Harris Research Lab
2025 STAT Wunderkind award to Dr. Singh
Neutralization of Zika with IgM developed in pregnancy (Cell, 2022)
Infection history shapes Dengue response (Nat Comm, 2024)
Longitudinal profiling of antibodies following Dengue infection (Nat Comm, 2026)
Exposure to Zika and risk for Dengue (Sci Transl Med, 2024)
AAI Public Policy Fellows Program
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.

Carla Rothlin joins Immune at AAI2026 to talk about her career studying inflammation regulation and how she co-founded the Global Immunotalks virtual seminar series.


Host: Cindy Leifer
Guest: Carla Rothlin

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TAM receptor signaling in immune homeostasis (Annu Rev Immunol, 2015)
MerTk in retinal pigment epithelial cells (Sci Adv, 2023)
Modifiers determine MerTk function (Elife, 2022)
Re-evaluating MerTk knockout mice (Int J Mol Sci, 2024)
TAMs for checkpoint blockade in cancer therapy (Immunol Rev, 2017)
Global Immunotalks on YouTube
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.

Immune tackles papers on the breadth of human B cell responses following mRNA vaccination and on the role of mitochondria and reactive oxygen species in plasma B cell maintenance.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of Immune!
Links for this episode
MicrobeTV Discord Server
mRNA flu vaccine expands B cell breadth (Nat Immunol, 2026)
Mitochondrial ROS and plasma cells (Nat Commun, 2026)
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.

Tanya Mayadas joins Immune to talk about her road to study neutrophils and her research findings on neutrophil antigen presentation and novel neutrophil targeting therapies.


Host: Cindy Leifer
Guest: Tanya Mayadas
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Tanya recently appointed department chair and director
Neutrophils, von Willebrand factor and P-selectin (Cell, 1991)
P-selectin knockout mouse (Cell, 1993)
Neutrophils as antigen presenting cells in cancer (Nat Comm, 2021)
Neutrophils elicit broad anti-tumor immunity (Cancer Res Comm, 2026)
FcR-mediated neutrophil recruitment (Circulation, 2009)
Neutrophil classification and heterogeneity (Immunity, 2025)
Neutrophils in Lupus (Curr Op Rheumatol, 2019)
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.