Possible

This is the first of a special, three-part Reid Riffs miniseries. Instead of a news-and-headline driven conversation, Reid sits down one-on-one with Parth Patil, an AI engineer and strategist, for a deeper exploration of what it actually means to become AI-native. In this first episode of the series, Parth and Reid discuss how individuals can better leverage LLMs, agents, and creative tools daily. They trace the shift from seeing AI as a productivity boost to understanding it as a meta-tool, as well as unpack techniques like role-based prompting, meta-prompting, and voice as a high-bandwidth thinking interface. Along the way, they discuss the humility required to collaborate with these systems, the move from a single copilot to orchestrating fleets of specialized agents, and how these tools are already reshaping workflows. Subscribe below to catch the second episode on how large companies can integrate AI, as well as the third episode for startup founders and their early teams building AI-native companies.  For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/  01:07 – When ChatGPT became an “everything tool” 03:11 – Role-based prompting and meta-prompting 07:04 – Ego, humility, and the GPT-4 inflection point 10:41 – Why voice is the highest-bandwidth interface 14:15 – Choosing models and building an AI stack 18:09 – From one copilot to fleets of agents 21:11 – When agents go wrong 25:40 – Using AI as an agent, not a chatbot 28:34 – Building real systems with AI agents 32:49 – Context engineering and advanced prompting 36:03 – Becoming AI-native 40:34 – Closing

On this episode of Possible, Reid Hoffman and Aria Finger sit down with Amjad Masad, founder and CEO of Replit, to explore how AI is fundamentally changing who gets to build software and what that means for work, creativity, and human agency. Masad traces his journey from growing up in Jordan teaching himself to code and connects it to his love of video games which helped inspire him to build a platform that turns natural language into working software. The conversation spans everything from why gaming mindsets make better builders, to how CEOs are rediscovering hands-on creation, to why “vibe coding” is the next form of literacy and why computational thinking is more important than syntax mastery. The conversation also digs into the future of AI agents, long-running autonomous workflows, and what it means to design environments for machines rather than humans. They also confront harder questions about jobs, fear, regulation, and society’s responsibility during a cognitive industrial revolution. The episode ultimately reframes AI not as a replacement for human creativity, but as a force that can return people to a more entrepreneurial, expressive, and meaningful way of life.  For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ 01:45 – Introductions and Amjad’s background 02:07 – Growing up in Jordan, video games, and learning to build 06:19 – How gaming culture shaped Replit’s product philosophy 09:55 – Designing Replit around safety, reversibility, and exploration 13:24 – Defining vibe coding and where the term came from 15:55 – The new literacy: computational thinking and soft skills 22:09 – Getting past the blank page and learning by making 25:06 – Entrepreneurs, solopreneurs, and who Replit empowers 30:48 – Designing environments for AI agents and durable businesses 35:55 – Open source, abstraction, and “cathedrals built from bazaars” 38:25 – The future of corporate work and creative ownership 48:29 – Fear, skepticism, and cultural responsibility around AI 54:13 – Jobs, disruption, and becoming AI-native in a changing economy 01:11:12 – Rapid Fire Questions

This is a bonus episode from the Conversations of Coleman podcast, featuring Reid Hoffman as the guest. Here are the show notes from that episode: My guest today is entrepreneur and LinkedIn co-founder Reid Hoffman. He’s now facing something most tech business people never imagine: being personally targeted by a sitting president’s Department of Justice. Reid and I talk through the rise of politically motivated prosecutions, the erosion of trust in institutions, and how social media and AI have accelerated our collective slide into suspicion. We get into deepfakes, vaccine skepticism, the inequality debate, and whether billionaires should exist at all. Reid also walks me through what it’s like to wait for an indictment he believes is purely retaliatory. This is a conversation about democratic guardrails, not partisan talking points—and about what happens when political power becomes personal. A big thanks to The Free Press and Conversations with Coleman podcast, available at theFP.com.

This is a holiday special re-airing of our excellent episode with Stephen Colbert. What could we gain—and what might we lose—when technology begins to approximate the contours of human connection and presence? In this episode, Reid and Aria chat with comedian, actor, and political commentator Stephen Colbert. Best known for hosting The Colbert Report and The Late Show, Stephen combines a razor sharp satire with a sincere curiosity about the world. Together, Reid, Aria, and Stephen discuss the art of live performance, the many lessons one can learn from J.R.R. Tolkien, and the nature of creativity, humor, and imagination in the age of AI. The result is a meditation on discovery, empathy, and the bonds that make connection more than performance — but a shared act of being human.

In this special episode of Reid Riffs, Reid and Aria are joined by Pulitzer Prize–winning author, oncologist, and Manas AI cofounder Siddhartha Mukherjee for a few questions about cancer, AI, and the second edition of The Emperor of All Maladies. Reflecting back on the 15 years since its initial publication, Reid, Aria and Sid discuss how cancer prevention, early detection, and immunotherapy have fundamentally shifted while the disease continues to be a defining challenge of modern medicine. The conversation charts how AI can become a true engine of drug discovery and how Manas was built to be an AI-native biopharmaceutical company focused on developing entirely new medicines. The episode then broadens out to tackle the current cultural moment in Silicon Valley, questioning whether the Valley is entering a new Renaissance driven by more meaningful work, clearer values, and a renewed theory of human progress. The episode closes by grappling with AI’s growing persuasive power in politics and public discourse, and the responsibility to design systems that elevate truth, agency, and humanity rather than distort them.