CT10 is a Anaesthetic Primary Podcast series. We discuss various topics ranging from physiology, pharmacology, clinical measurement and equipment that are relev...
EP32 – Intro to Pharmacodynamics | Anaesthetic Primary Topic | General Pharmacology | CT10
Today we start our new series of General Pharmacology Principles. The first topic is “Intro to Pharmacodynamics.” I start by discussing the different MOA a drug can work by and then having a deeper look at receptors (01:54). Then I look at the Law of Mass Action and how this applies to receptor affinity (10:32). This brings me to a very important LO which examines the dose-effect relationships of drugs with a look a at some really important graphs (13:42). There is only one SAQ to review at the end (29:56). Next episode I will go through ‘Intro to PK.’ Thanks for listening! As always if you have any feedback let me know @ [email protected]
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37:15
EP31 – Propofol TCI Pharmacokinetics with Dr Anthony| CT10
Happy New Year! I’m joined today with a very special guest and current primary exam examiner Dr Anthony. In this episode we take a in depth look at the Pharmacokinetics of Propofol TCI. Anthony has curated this talk over multiple years and starts of by explaining the main equations you should know (05:35). We then integrate these equations into the classic Propofol Cp vs Time graph (11:52). This leads us on to talking about the compartment model (20:11) and how this applies to the ‘Marsh’ TCI model (23:25). To help understand the concepts of rate constants (k) Anthony uses his bucket analogy (27:27). Then we apply this knowledge to understand effect site targeting (Ce) and run through some examples of differences in age (41:30) and weight (66:05). Finally, we finish with a brief look at the ‘Eleveld’ Model and the concept of Keo (72:40). A huge thank you to Anthony and as always if you have any feedback let me know. Sources/Credit: All equations/graphs/diagrams/tables – Miller’s Anesthesia 10th Edition 2025 All TCI calculations – simtiva.app End Episode Song – “The Volatiles”
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EP30 – Immunology & Hypersensitivity with Justin | CT10
I’m joined today by a special guest Justin and we go through an overlooked topic of ‘Immunology & Hypersensitivity.’ The first learning objective is to review how the body defends against infection (05:46) and then look how this is effects under anaesthesia (14:06). Finally, we have a long conversation about the pathophysiology of hypersensitivity (16:22) and the clinical context of the treatment of anaphylaxis (24:18). I want to thank Justin again for joining me today and as always if you have any feedback let me know.
Today is the last topic of our cardiac physiology series “Measurement.” I start of by looking at different techniques to measure non-invasive BP from auscultation (01:31) to oscillometry (07:03). Then I look at an invasive method being arterial lines and this is divided into how it works (11:15) and sources of error (17:54). The last LO for today covers different techniques to measure cardiac output (27:41). To finish as always, we look at the past SAQs (33:35). Thanks for listening! As always if you have any feedback let me know
In today’s episode I cover the ‘Past Saqs’ from ‘Applied Cardiac Physiology.” The first SAQ looks at the consequence of tourniquet release after two hours (01:23) followed by the process’s that cause oliguria in hypovolemic shock (09:45). Then I go through the model answers for CVS responses in severe blood loss (14:39), the effects of infusing Hartmann’s solution (16:51) and briefly the impact of IPPV (21:52). Finally, the remaining SAQs look at the effects of a central neuraxial blockade (22:44), the effects of a pneumoperitoneum (27:01) and the effects of ageing and obesity (30:57). Good luck to all the viva sitters this week and thanks for listening! As always if you have any feedback let me know
CT10 is a Anaesthetic Primary Podcast series. We discuss various topics ranging from physiology, pharmacology, clinical measurement and equipment that are relevant to Anaesthesia training in Australia and New Zealand. Our aim is to share knowledge that can help medical and nursing staff working in anaesthesia.
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