Pamela Maher - from cell death to Alzheimer's therapies. Performance Around the Clock ep34.
Welcome to episode 34 of the Performance Around the Clock. In this episode, host Dr. Satchin Panda, welcomes his esteemed colleague, Dr. Pamela Maher from the Salk Institute for Biological Studies. Dr. Maher is a rare scientist who has taken drug discovery from basic science findings in cells all the way to compounds being tested in human clinical trials. In this episode, they discuss her journey through research on cell membranes and signaling, leading to her pivotal work on cell death pathways like oxytosis and ferroptosis. The conversation also covers the development of potential therapeutics for aging and Alzheimer's disease, including compounds like J147 and CMS-121, and the exploration of cannabinoids for neuroprotection. If you like this episode, please like, comment or follow. Thank you for listening.Guest:Dr. Pamela MaherResearch Professor at the Salk InstituteCellular Neurobiology LaboratoryProfile:https://www.salk.edu/scientist/pamela-maher/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/
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Susan Golden - cyanobacteria and circadian rhythms. Performance Around the Clock episode 33.
Welcome to the Performance Around the Clock podcast. In this episode, Dr. Satchin Panda welcomes one of his scientific heroes, Dr. Susan Golden. Dr. Golden is a pillar in the circadian and cyanobacteria science community and the former director for the Center for Circadian Biology at UC San Diego. She shares her journey from studying gene regulation in cyanobacteria to understanding the circadian clock through this unique organism. Learn how these ancient blue-green algae were instrumental in the oxygenation of Earth's atmosphere and how tools developed to study cyanobacteria led to groundbreaking discoveries. Beyond her research, Dr. Golden also made significant contributions to circadian rhythm education, teaching countless undergraduate students over the years. If you like this episode, please like, comment or subscribe. Thank you for listening.Guest:Dr. Susan GoldenDirector, Center for Circadian BiologyChancellor's Associates Chair (III) in Molecular BiologyDistinguished ProfessorX (Twitter): @susanksgoldenhttps://x.com/susanksgoldenProfile:UCSD:https://biology.ucsd.edu/research/faculty/sgoldenWikipedia:https://en.wikipedia.org/wiki/Susan_GoldenPaper:Circadian orchestration of gene expression in cyanobacteriahttps://pubmed.ncbi.nlm.nih.gov/7601351/Thanks to 理philosophia onlineについて for the photo of Dr. Takao Kondohttps://www.philosophia.sci.nagoya-u.ac.jp/snapshots/44.htmlHost:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/
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1:48:10
John Newman and Brianna Stubbs - ketones and aging. Performance Around the Clock ep32.
In our last episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are honored to host Dr. John Newman and Dr. Brianna Stubbs, both experts in ketone metabolism and aging. Dr. Newman is a geriatrician and researcher at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF. His research focuses on how ketone bodies, small molecules that our bodies make for energy during fasting or exercise, also work as molecular signals to control inflammation and gene expression. Dr. Brianna Stubbs is an expert in exogenous ketone metabolism and the Director of Translational Science at the Buck Institute for Research on Aging. She's a former competitive rower and two-time world champion, and she completed her PhD in metabolic physiology at the University of Oxford, where she studied the metabolic effects of ketone esters. Learn all about their work translating ketone research into the field. If you like this episode or podcast, please like, comment or follow. Thank you for listening. Guests:Dr. John NewmanDivision of Geriatrics at UCSFAssistant Professor Buck Institute for Research on AgingX (Twitter): @geriscidochttps://x.com/geriscidocProfile:Division of Geriatrics at UCSFhttps://profiles.ucsf.edu/john.newmanhttps://medicine.ucsf.edu/people/john-newmanBuck Institute for Research on Aginghttps://www.buckinstitute.org/lab/newman-lab/Dr. Brianna StubbsDirector of Translational Science at Buck Institute for Research on AgingX (Twitter): @briannastubbshttps://x.com/briannastubbsHost:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/
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Nathan LaBrasseur - senescence and aging. Performance Around the Clock episode 31.
Coming from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are excited to welcome Dr. Nathan LaBrasseur for the 31st episode of the Performance Around the Clock podcast. Dr. LaBrasseur is the director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic and an expert on senescence and aging. He's an author of the book "Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilled" an updated guide on healthy aging. In this episode, learn about the latest in aging and senescence particularly therapeutics for senescent cells - senotherapeutics. Senotherapeutics can be broken down into senolytics which selectively kill senescent cells and senomorphics which suppress senescence-associated secretory phenotype (SASP) to reduce the negative effects of senescence. Thank you for watching. If you like this episode, please like, comment or subscribe. Guest:Dr. Nathan LaBrasseurDirector of the Robert and Arlene Kogod Center on Aging @MayoClinicX (Twitter): @NKLeBRASSEURhttps://x.com/nklebrasseurProfile:https://www.mayo.edu/research/faculty/lebrasseur-nathan-k-ph-d-m-s/bio-00055041Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilledhttps://www.amazon.com/Mayo-Clinic-Healthy-Aging-Comprehensive/dp/B0BQYKS8NDHost:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/
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1:11:38
Courtney Peterson - intermittent fasting and TRE. Performance Around the Clock episode 30.
We continue our series from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle. Episode 30 of the Performance Around the Clock Podcast, features Dr. Courtney Peterson, a leading researcher in the field of intermittent fasting and time-restricted eating (TRE). Dr. Peterson is an Associate Professor at the University of Alabama at Birmingham where she was notably the first to test early time-restricted eating (eTRE) in humans. Dr. Peterson is the principal investigator of numerous clinical trials on TRE, including the largest randomized controlled trial of intermittent fasting in individuals with type 2 diabetes. Her research combines chronobiology, nutrition, and metabolism and aims to develop dietary interventions to combat cardiometabolic diseases. Learn all about her research in this episode. If you like this episode, please like, comment or subscribe. Thank you for listening. Guest:Dr. Courtney PetersonAssociate Professor University of Alabama BirminghamX (Twitter): @CourtneyP_PhDProfile:https://scholars.uab.edu/3393-courtney-peterson Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabeteshttps://pubmed.ncbi.nlm.nih.gov/29754952/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: https://mycircadianclock.org/
This is a podcast that explores how to keep our bodies and minds operating at peak levels around the clock, hosted by Dr. Satchin Panda from the Salk Institute in La Jolla, CA. Here, we talk with experts from different fields to learn about science and how to leverage that knowledge to improve performance.
Dr. Panda is a leading expert on circadian rhythms and time-restricted feeding. His research has implications on metabolism, health, and aging and offers potential approaches to disease prevention and longevity.
New Zealand