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Vaccine study retraction request rejected
US Health Secretary RFK Jr’s call to retract a study on childhood vaccines is resisted by the journal. Also antibiotics get designed by AI, and a new way for stars to die. A study focussing on Danish childhood vaccination data has attracted the US Secretary for Health’s anger, as RFK jr calls for the journal in which it was published, the Annals of Internal Medicine, to retract it. The Editor, Christine Laine, talk to Science in Action about the strengths and challenges of observational studies. The cuts to prestigious US federal science funded research continue, as last week it was announced that $500 million funding for future mRNA vaccines would be withdrawn. Barney Graham, one of the pioneers in the field and prominent during the Covid vaccines, argues that the research will still happen, though maybe not in the US, as mRNA has become a fundamental area of global research. Meanwhile, strides are being made in the field of synthetic biology as Jim Collins and colleagues at MIT and Harvard have used AI to design potentially viable antibiotics for two important drug-resistant superbugs. Previously, AI has been used to comb through libraries of known antibiotics. This study has gone a step further, and used generative AI to design new ones, that can then be synthesised using real chemicals. Though a long way from being prescribable drugs, the team think this could herald a new golden age of antibiotic development – something which has been lacking in recent decades. Finally, it seems astronomers may have discovered a new way for a star to die, sort of. Supernova 2023zkd was seen to explode back in 2023, found by a team looking for odd events. It didn’t seem quite like normal supernovae, in that it took a bit longer to die down. Then the team looked back, and noticed that it had also been getting slowly brighter for almost a year. At 730 million light years away, in a galaxy far, far away, it also seemed to have been stripped of all its hydrogen and even stranger yet, appeared to have exploded twice. As Ashley Villar of the Harvard Smithsonian Center for Astrophysics explains, the almost unique observation fits with a model of the huge star getting closer to a black hole, the gravity of which may have disrupted the star enough to cause it to explode. Presenter: Roland Pease Producer: Ella Hubber with Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: Child getting a vaccine. Credit: Luis Alvarez via Getty Images)
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An end to allergic reactions?
As the United States secretary of health and human services, Robert F Kennedy Jr., announces a $500 million cut to mRNA vaccine research in the United States, we hear a statement from the Nobel Prize winning biologist who made mRNA vaccines possible. A team of scientists from Northwestern University have uncovered the pathway believed to protect some people from allergic reactions (even when they are sensitive to an allergen) and have tested a drug which could protect the most severely allergic. Also this week, satellite data shows that large parts of the Earth are running dangerously low on ground water. And although people often believe scientific fraud is committed by a few bad actors, a new paper uncovers networks of journals, editors, and authors who are allegedly cooperating to publish fraudulent papers. Presenter: Roland Pease Producer: Ella Hubber and Alex Mansfield Assistant Producer: Minnie Harrop Production Coordinator: Jana Bennett-Holesworth (Image: Allergy testing. Credit: Peter Dazeley via Getty Images)
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Getting ahead of tsunamis
After most of the population of the Pacific rim sought higher ground this week, we speak with the architect of the tsunami warning technology. Also how aging Killifish might help us probe our senior moments. This week, an M8.8 earthquake near Kamchatka in the western pacific led to tsunami evacuation alerts thousands of miles away. Seismologist Judith Hubbard was writing about the area in the days leading up to it, following a M7.4 event 9 days before, which we now know to categorize as a foreshock. As she says, it’s these subduction zones between tectonic plates that give out the most energy, produce the biggest quakes, leading to the worst tsunamis. The Tsunami alarms were based on modelling developed by Vasily Titov of NOAA’s Pacific Marine Environmental Laboratory in Seattle. Having studied these phenomena for many decades, he describes the fine balance between the potential accuracy of a prediction, and the practical actionable advice authorities need to give out to save as many lives as possible. Finally, how can a short-lived African freshwater fish help scientists studying senescence? Stanford’s Judith Frydman and colleagues publish this week a study in Science that finds Killifish’s brain cells’ ability to encode proteins degrades with age, in keeping with similar patterns of older human brains. Because Killifish have such brief life cycles, yet seem to follow the brain cycles of most vertebrates, they provide an ideal model species from which to find out more, as she explains. Presenter: Roland Pease Producer: Imaan Moin and Alex Mansfield Production Coordinator: Jana Holesworth(Image Credit: Vasily Titov PMEL/NOAA)
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Discovering Betelgeuse’s Betelbuddy
Have we found Betelgeuse’s ‘Betelbuddy?’ An astronomical mystery seems to be solved as the long-predicted stellar companion to the bright star Betelgeuse has been detected by a team of researchers led by Steve Howell of the NASA Ames Research Center using the Gemini North telescope in Hawaii. Steve discusses this breakthrough alongside astronomer Andrea Dupree of the Harvard Smithsonian Center for Astrophysics, who has discussed the predictions of this star on previous Science in Action programmes. Malaria is a mosquito-borne disease caused by the parasite plasmodium that kills more than half a million people each year. George Dimopoulos of the Johns Hopkins Malaria Research Institute is using gene editing and gene drive technology to target the parasites as they develop in the guts of mosquito. Can this new method disrupt the malaria parasite life cycle safely and sustainably? Our gut microbiomes are linked to our brains, but how can the bacteria in our colon communicate with our nervous system? M. Maya Kaelberer of the University of Arizona explains this neurobiotic sense, suggesting that the microbes in our large intestine communicate with specialised sensory cells in the gut. These cells send signals up to our brain and regulate our appetite. So, who really decides when you're hungry? Is it you, or is it your microbiome? Presenter: Roland Pease Producer: Imaan Moin with Alex Mansfield Production Coordinator: Jana Bennet-Holesworth (Image: Betelgeuse and Its Stellar Companion in Orion. Credit: International Gemini Observatory/NOIRLab/NSF/AURA Image Processing: M. Zamani (NSF NOIRLab))
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Biggest black hole merger observed
Two black holes have collided and combined in the largest merger yet observed. Mark Hannam of Cardiff University and member of the study explains how the Interferometer Gravitational Wave Observatories (LIGO) detected this ‘violent’ event through spacetime. The lifestyle of ancient humans had an impact on their risk for infectious diseases. Astrid Iversen of the University of Oxford explains how the shift away from being hunter-gatherers played a role in the origins of human pathogens. Nitrogen fixation, or the process of organic compounds accessing nitrogen from the atmosphere via microorganisms, plays a key role in climate modelling. But prior estimations have long been missing key data to make accurate analysis. Carla Reis Ely of Oak Ridge Institute for Science and Education shares the updated facts and figures on global nitrogen fixation. How intelligent is artificial intelligence? Can AI start discovering new scientific laws in the year? Keyon Vafa of Harvard University put several AI models to the test to see if they could discover Newton’s law of gravity and understand the world around us. Presenter: Roland Pease Producer: Imaan Moin Production Coordinator: Jana Bennet-Holesworth (Image: Black Hole, digital illustration. Credit: Aaron Horowitz via Getty Images)
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