Mayim Bialik's Breakdown

What if EVERYTHING we know about reality is missing a deeper operating system?

In this episode of Mayim Bialik's Breakdown, Dr. Brian Keating (professor of physics, experimental cosmologist, and host of the Into the Impossible podcast) dives into the biggest unanswered questions in science, consciousness, God, the Big Bang, extraterrestrial life, simulation theory, and the hidden limits of human knowledge.

Dr. Keating breaks down:
- Why humanity NEEDS a Grand Unified Theory before we can ever reach a true “Theory of Everything”, and how scientists are trying to uncover the operating system of reality itself
- “A telescope is a time machine”: How looking into deep space is literally looking backward through time toward the origins of existence
- Shocking scientific and philosophical implications of the Big Bang, and the terrifying question: What was BEFORE time?
- Could another universe have collapsed to create ours?
- Why studying space-time itself may unlock secrets hidden before the beginning of the universe
- Why the Big Bang explains the expanding universe, and where modern cosmology still breaks down
- How Dr. Keating reconciles being both a scientist & a person of faith
- Can God & science coexist? How God may tie into the creation of the universe through a scientific lens
- Why God’s existence should not be subjected to scientific testing
- Hidden limits of both religion AND scientific data
- Where consciousness may actually come from according to modern physics
- Why the role of scientists is not to “prove” things
- Why even world-famous scientists secretly struggle with imposter syndrome
- Deistic implications of the Simulation Hypothesis, and whether reality itself could be engineered
- Search for extraterrestrial life: why we still have ZERO confirmed evidence despite viral claims
- Debunking alleged “signs of life” on Mars and separating science from speculation
- His take on the mysterious deaths and disappearances of U.S. scientists connected to nuclear & aerospace research
- Could unexplained events be connected to UAPs, nonhuman intelligence, or classified technology?
- Cattle mutilations, alleged energy weapons, and why unexplained phenomena always breed suspicion
- Why uncertainty is one of the most dangerous (and fascinating) forces in human civilization

This episode explores the edge where cosmology, philosophy, consciousness, religion, and the unknown collide.

If you’re fascinated by the Big Bang, aliens, simulation theory, UAPs, consciousness, physics, God, or the future of humanity, this conversation will completely change how you think about reality itself!

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Dr. Brian Keating’s podcast, Into the Impossible: https://www.youtube.com/playlist?list=PLJGKdZD30K_9rVCDAdRSwoJLi5ls6JN-q
Dr. Brian Keating’s books: https://briankeating.com/books/
Learn more about The Simons Observatory and their search for cosmic origins: https://simonsobservatory.org/

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She escaped an arranged marriage the DAY AFTER her mother died…and what happened next will leave you speechless.

In this unforgettable episode of Mayim Bialik's Breakdown, Zarna Garg reveals the raw, shocking, and deeply inspiring story behind her rise, from fleeing tradition under unimaginable circumstances to becoming one of the boldest voices in comedy today.

After losing her mother, Zarna made a life-altering decision overnight—running away from an arranged marriage and surviving by couch surfing for 2 years. What kept her going? A surprising legacy of kindness her mom left behind that saved her life.

From immigrating to America with nothing, to redefining her identity on her own terms, Zarna shares what America truly means to her and why she believes destiny had a hand in her success.

She opens up about love, loss, and rebellion - how she navigated dating solo (including her wildly unique online dating ad!) and ultimately found her perfect match.

Encouraged by her own kids, Zarna took a leap into stand-up comedy...and never looked back. Today, she’s breaking stereotypes, pushing boundaries, and challenging cultural norms with every punchline.

Zarna addresses the backlash she faced for performing at the Riyadh Comedy Festival—and why she did it anyway, hoping to inspire women in marginalized communities.

She gets real about the tough questions:
- Did her father’s death change how she sees karma?
- Why should you NEVER ask your partner “what are you thinking?”
- Is Western culture completely misunderstanding yoga?
- Are beauty standards harsher in India or America?

Plus, her hilarious takes on:
- Growing up influenced by American culture & sibling birth order
- Why she loves Mayim's "Amy Farrah Fowler" character from The Big Bang Theory
- Balancing cultural pride without “demonizing” her roots for Western audiences

Zarna also shares her powerful belief that ALL religions hold value, and how she’s built her own philosophy by taking the best from each.

This is more than comedy. It’s survival, rebellion, identity, and destiny...all wrapped in one incredible story you don’t want to miss. Her perspective might completely change how you see culture, courage, and what it really means to choose your own life!

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Dr. Rick Doblin (founder and president of the Multidisciplinary Association for Psychedelic Studies, and one of the most influential figures in psychedelic science) returns to Mayim Bialik's Breakdown for one of the most controversial and eye-opening conversations on psychedelics we've had yet.

From the shocking experiment where scientists gave MDMA to an octopus, to why ibogaine may be the most powerful AND dangerous psychedelic ever studied, this episode explores the future of psychedelic therapy, trauma healing, addiction recovery, policy reform, and human consciousness itself.

We break down Trump’s new executive order accelerating psychedelic research and what it could mean for the future legalization of psychedelic-assisted therapy in America. Dr. Doblin explains why veterans suffering from PTSD and disabilities have become central to bipartisan support for psychedelics, and why this issue is now reshaping politics on both sides of the aisle.

We also dive deep into ibogaine: its mysterious origins, its ability to help reset opioid addiction, its connection to ancestral memory and intergenerational trauma, why it carries serious risks, and why Dr. Doblin still believes its benefits may outweigh the dangers. He also shares his own profound ibogaine experience that helped him confront perfectionism and his fear of death.

Dr. Doblin discusses:
- How psychedelics help people integrate trauma
- Why psychedelics are generally considered non-addictive
- Difference between recreational vs therapeutic psychedelic use
- Why psychedelic treatment should be customized to each patient
- Importance of integration, peer support, and paying attention to dreams after treatment
- Measures of success in MDMA-assisted couples therapy
- Origins of the opioid epidemic
- "Psychedelic churches": How organizations are openly operating under the umbrella of religion
- Capitalism vs democratizing the benefits of psychedelic medicine
- How a better psychedelic therapy model could be built
- Why transparency is critical for science-backed drug policy reform
- When psychedelics may realistically enter the open market
- Dr. Doblin’s long-term vision for a psychedelic-informed public

As psychedelic research rapidly expands worldwide, this conversation explores the science, politics, risks, ethics, and revolutionary potential behind one of the fastest-growing movements in mental health and medicine!

DISCLAIMER: MBB is not providing medical or legal advice. Listeners should speak to their doctor before engaging in any course of psychedelic protocols. Psychedelics are still illegal in many places - MBB is not encouraging engaging in illegal substance use, but simply sharing the latest scientific insights from our guests.

Learn more about MAPS & their research: https://maps.org/
To learn more about the world’s largest psychedelic conference, Psychedelic Science, taking place in Denver, CO next year, visit: https://virtualtrip.maps.org/

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Dr. Rick Doblin (founder and president of the Multidisciplinary Association for Psychedelic Studies, and one of the most influential figures in psychedelic science) returns to Mayim Bialik's Breakdown for one of the most controversial and eye-opening conversations on psychedelics we've had yet.

From the shocking experiment where scientists gave MDMA to an octopus, to why ibogaine may be the most powerful AND dangerous psychedelic ever studied, this episode explores the future of psychedelic therapy, trauma healing, addiction recovery, policy reform, and human consciousness itself.

We break down Trump’s new executive order accelerating psychedelic research and what it could mean for the future legalization of psychedelic-assisted therapy in America. Dr. Doblin explains why veterans suffering from PTSD and disabilities have become central to bipartisan support for psychedelics, and why this issue is now reshaping politics on both sides of the aisle.

We also dive deep into ibogaine: its mysterious origins, its ability to help reset opioid addiction, its connection to ancestral memory and intergenerational trauma, why it carries serious risks, and why Dr. Doblin still believes its benefits may outweigh the dangers. He also shares his own profound ibogaine experience that helped him confront perfectionism and his fear of death.

Dr. Doblin discusses:
- How psychedelics help people integrate trauma
- Why psychedelics are generally considered non-addictive
- Difference between recreational vs therapeutic psychedelic use
- Why psychedelic treatment should be customized to each patient
- Importance of integration, peer support, and paying attention to dreams after treatment
- Measures of success in MDMA-assisted couples therapy
- Origins of the opioid epidemic
- "Psychedelic churches": How organizations are openly operating under the umbrella of religion
- Capitalism vs democratizing the benefits of psychedelic medicine
- How a better psychedelic therapy model could be built
- Why transparency is critical for science-backed drug policy reform
- When psychedelics may realistically enter the open market
- Dr. Doblin’s long-term vision for a psychedelic-informed public

As psychedelic research rapidly expands worldwide, this conversation explores the science, politics, risks, ethics, and revolutionary potential behind one of the fastest-growing movements in mental health and medicine!

DISCLAIMER: MBB is not providing medical or legal advice. Listeners should speak to their doctor before engaging in any course of psychedelic protocols. Psychedelics are still illegal in many places - MBB is not encouraging engaging in illegal substance use, but simply sharing the latest scientific insights from our guests.

Learn more about MAPS & their research: https://maps.org/
To learn more about the world’s largest psychedelic conference, Psychedelic Science, taking place in Denver, CO next year, visit: https://virtualtrip.maps.org/

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As we wrap up Mental Health Month, we’re revisiting another super helpful and practical episode from 2 years ago with motivation expert, physician, public health leader, and behavior change designer, Dr. Kyra Bobinet who helped us discover the secret part of your brain that controls motivation and what you might be doing to unknowingly sabotage your success.

Dr. Bobinet breaks down the mysterious habenula and explains how to achieve your goals. Discover why your To-Do Lists & New Year’s resolutions are secretly hurting you. Learn how to truly lose weight, succeed in relationships, and why faking orgasms might lead to addiction!! Stop everyday habits that may be destroying your motivation. We’re unveiling the shocking secrets of failure and imposter syndrome that are holding you back from true greatness - Are you unknowingly setting yourself up to fail?

Dr. Bobinet also explains:
- Benefits of dopamine fasting
- Different types of failure
- Dangers of doom-scrolling
- Ties between addiction, depression, and failure
- How to regulate your environment to reduce your chances of failure
- Best sources of motivation for short term goals vs long term goals
- Ketamine effects on the habenula in treating depression
- Why porn can be so addictive to some
- Why we’re more likely to focus on losses vs wins
- What triggers imposter syndrome and who is most susceptible to it
- Positive & negative effects of the latest GLP-1 weight loss drugs on the brain
- Process of deep brain stimulation
- How to hack your way out of avoidant attachment
- Effects of inauthenticity in sexual relationships
- Downside of institutions overusing performance-based tools
- Difference between “performing” vs authentically being

Learn practical ways to form healthy habits and literally change your brain to avoid & move through failure!

Check out Wondering Jews with Mijal and Noam podcast and subscribe: https://unpacked.bio/nmx

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