Meclizine is classified as a first-generation antihistamine. I discuss meclizine pharmacology, adverse effects, drug interactions, and much more.
Meclizine is included on the Beers list due to its highly anticholinergic activity. Anticholinergic effects include constipation, dry eyes, dry mouth, urinary retention, and confusion.
Sedation is an important adverse effect of meclizine. This adverse effect can be increased when used with other sedating medications such as opioids and benzodiazepines.
Meclizine is primarily used for vertigo and motion sickness in clinical practice. The usual starting dose ranges between 12.5 to 25 mg.
Meclizine is partially broken down by CYP2D6 so medications like bupropion can inhibit the breakdown of meclizine and lead to higher concentrations.
In this episode, I discuss amphetamine/dextroamphetamine pharmacology, adverse effects, drug interactions, and much more.
Stimulants like Adderall are well known to cause insomnia. This adverse effect can be affected by the timing of the dose.
Lack of growth and poor appetite are two important things to monitor in pediatric patients taking Adderall.
Changes in the pH of the stomach/gut can alter the absorption of Adderall. I discuss this in greater detail in this podcast episode.
Cardiovascular monitoring is essential with the use of stimulants like Adderall. Pulse and heart rate are two important vital signs to assess.
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17:47
Benazepril Pharmacology Podcast
Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here!
Benazepril is an ACE inhibitor used to treat hypertension by blocking the conversion of angiotensin I to angiotensin II, reducing vasoconstriction.
Combining benazepril with potassium-sparing diuretics or potassium supplements increases the risk of hyperkalemia due to aldosterone suppression.
Common side effects of benazepril include dry cough, hyperkalemia, and hypotension due to its effect on the renin-angiotensin-aldosterone system.
Benazepril can be prescribed alone or in combination with other antihypertensive agents, such as diuretics or calcium channel blockers, to enhance blood pressure control.
Benazepril has a long duration of action, allowing for once-daily dosing, which improves patient adherence and convenience in hypertension management.
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18:09
Loratadine Pharmacology Podcasst
Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here!
On this podcast episode, I cover loratadine pharmacology, adverse effects, drug interactions, and much more.
Loratatdine is a second generation antihistamine. It has a lower incidence of central nervous system adverse effects compared to first-generation antihistamines like diphenhydramine.
Loratadine dosing varies in pediatric patients and those with renal impairment. I get into the details on this podcast episode.
Drug interactions aren't common with loratadine but I discuss a few that may be clinically significant.
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12:56
Modafinil Pharmacology Podcast
Modafinil (Provigil) is a CNS stimulant medication. I cover modafinil pharmacology, adverse effects, drug interactions, and much more on this podcast episode.
You should be aware that modafinil is a Schedule 4 controlled substance so it does carry a risk of dependence and addiction.
Modafinil can cause CYP3A4 induction and lead to lowering the concentrations of many medications. This includes antiepileptic agents and oral contraceptives.
The most common adverse effects of modafinil include ramping up the body and causing symptoms such as anxiety and insomnia.
Cardiovascular changes are a risk with modafinil as this medication can contribute to hypertension and tachycardia.
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