Triangulation (Audio)

Hands-On AI is the show that turns AI confusion into AI confidence. In this trailer, Mikah Sargent lays out what the show is and isn't: short, focused episodes — most 10 to 15 minutes — that take one question, one tool, or one technique at a time. Some weeks go under the hood on what a large language model is actually doing. Some weeks get practical: the AI already in your pocket, or a model running entirely on your own computer. And some weeks are honest verdicts on the tools everyone's talking about.
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In a wide-ranging conversation, Leo Laporte talks with Dr. George Church about the history and future of genome sequencing. Dr. Church explains why he is very excited about how they made an organism resistant to all viruses- both known and unknown.

They also talk about:

How Dr. Church made sequencing affordable (from $3BN to $600)

Where are we on sequencing the entire human genome, and why would we even want to?

How close are we to reversing aging?

Should we use gene therapy to double the human lifespan?

Why genetically engineering cold-resistant elephants could be important for climate change, and what about ultimately bringing back the Mammoth?

He explains the difference between the hype and reality of CRISPR

sequencing, synthesis, and delivery

What are the privacy concerns about companies sharing your genome?

They discuss the controversy and benefit of reconstructing old viruses like the 1918 flu and even inventing new viruses.

Dr. Church is a professor of genetics at Harvard Medical School and a pioneer in personal genetics. He is credited with developing the first methods for sequencing the first genome and also the CRISPR technology. He created several companies, including Nebula Genomics and Veritas Genetics.

Host: Leo Laporte

Guest: Dr. George Church

Download or subscribe to this show at https://twit.tv/shows/triangulation.

New York Times bestselling author Daniel Suarez returns to talk with Leo Laporte about the second book in his 'Delta-v' novel series, 'Critical Mass,' where a group of pioneering astropreneurs must overcome never-before-attempted engineering challenges to rescue colleagues stranded at a distant asteroid—kicking off a new space race in which Earth's climate crisis could well hang in the balance.

Get 'Critical Mass': https://amzn.to/3Yjb9xu

Host: Leo Laporte

Guest: Daniel Suarez

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Writer/activist Cory Doctorow and scholar Rebecca Giblin join Leo Laporte to talk about their latest book Chokepoint Capitalism: How Big Tech and Big Content Captured Creative Labor Markets and How We'll Win Them Back. They argue that we're in a new era of "chokepoint capitalism," with exploitative businesses creating insurmountable barriers to competition that enable them to capture value that should rightfully go to others.

Get "Chokepoint Capitalism": https://chokepointcapitalism.com

Host: Leo Laporte

Guests: Cory Doctorow and Rebecca Giblin

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Tripp Mickle joins Leo Laporte to discuss his new book, "After Steve: How Apple Became a Trillion-Dollar Company and Lost Its Soul". They discuss the shift in Apple's dynamic and approach to products after the passing of Steve Jobs from a company of innovation with Jony Ive, to a company of efficiency under Tim Cook.

Host: Leo Laporte

Guest: Tripp Mickle

Download or subscribe to this show at https://twit.tv/shows/triangulation.