PodcastsLife SciencesGiants Shoulder

Giants Shoulder

Evan McGloughlin
Giants Shoulder
Latest episode

143 episodes

  • Giants Shoulder

    #134 - Neuroscientist: "Your Brain Doesn't Create Consciousness" — NDEs, Telepathy and Terminal Lucidity

    02/07/2026 | 1h 38 mins.
    Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqe
    Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about
    Marjorie Woollacott is a neuroscientist who spent three decades as a hard materialist and co-wrote the textbook used to train physiotherapists worldwide. After a meditation experience her own field said was impossible, she hid it from her colleagues for over 25 years before concluding the brain does not produce consciousness — it filters it.
    Expect to learn why a career materialist neuroscientist hid her own paranormal experience for 25 years, the prospective hospital studies that corroborate what patients report while clinically dead, how a comatose man with zero brain activity accurately described a nurse hiding his dentures, what terminal lucidity is and why dying Alzheimer's patients regain full clarity minutes before death, the ongoing lab research into non-speaking autistic children who appear to communicate telepathically, why Christof Koch said the data would turn his world upside down, how Bernardo Kastrup's analytic idealism compares to Woollacott's own theory of consciousness, and much more…
    Timestamps
    0:00:00 Trailer
    0:02:46 Where Her Story Really Begins
    0:05:05 The Materialist Neuroscientist She Used To Be
    0:06:15 The Meditation Retreat That Broke Her Skepticism
    0:14:24 What Actually Caused Her Awakening
    0:22:59 How Rigorous Is Near-Death Experience Research, Really
    0:24:19 The Prospective Studies Skeptics Ignore
    0:25:06 The Coma Patient Who Knew Where His Dentures Were
    0:35:48 Bernardo Kastrup's Analytic Idealism Explained
    0:43:19 Is Terminal Lucidity Just Wishful Interpretation?
    0:46:09 The Three-Year-Old's Last Request Before Dying
    0:53:07 Can Consciousness Move Physical Objects?
    0:58:20 Why Jung And A Nobel Physicist Believed In Idealism
    1:02:59 The Telepathy Tapes, Explained
    1:19:40 The Autism Vulnerability Problem With This Research
    1:21:21 The 5% Above Chance Telepathy Effect
    1:35:13 Designing an Experiment Skeptics Can't Dismiss...
    ...
    Email for sponsorship enquiries: evan@thegiantsshoulder.com
    GS Episodes Mentioned
    Christof Koch — The Psychedelic Trip that Convinced Christof Koch Consciousness is Fundamental: https://www.youtube.com/watch?v=kJlV-b2bvaE
    Guest Links
    Website: https://marjoriewoollacott.com/
    University of Oregon Faculty Page: https://ion.uoregon.edu/about/person-page/459
    Book – Infinite Awareness: https://www.amazon.com/Infinite-Awareness-Awakening-Scientific-Mind/dp/144225033X
    Academy for the Advancement of Postmaterialist Sciences Bio: https://www.aapsglobal.com/marjorie-woollacott/
    ResearchGate: https://www.researchgate.net/profile/Marjorie-Woollacott
  • Giants Shoulder

    #133 - Meet The Most Important Man Alive In The History of MDMA

    29/06/2026 | 1h 13 mins.
    Check out Scispace (JNGIANT20: 20% off the monthly plan or JNGIANT40: 40% off the annual plan): https://scispace.com/?via=jun1giantshoulder
    Get Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulder
    Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

    Rick Doblin is the founder of MAPS and the man who spent 50 years dragging the world's most demonized drug into the doctor's office. He taxed legal ecstasy dealers to fund the first MDMA toxicity studies, sued the DEA with the profits, and got a Harvard PhD in public policy to beat the system from inside — then ran the only completed Phase 3 trials in history showing that two-thirds of severe PTSD patients no longer had the diagnosis after MDMA-assisted therapy.
    Expect to learn how he taxed ecstasy dealers to sue the DEA, why MDMA was a couples-therapy drug before it was a party drug, the real reason Nixon criminalized psychedelics in 1970, why 88% of severe PTSD patients responded to MDMA therapy while half dropped out of standard VA treatment, why you can't get addicted to MDMA the way you can to cocaine, why you'll do more jail time for MDMA than for the same weight of cocaine, his plan for "net zero trauma by 2070," and much more…
    Timestamps
    0:00:00 Trailer
    0:03:03 Winning the Generational Lottery After the Holocaust
    0:05:27 Dropping Out of College to Study LSD
    0:08:15 The Forgotten Golden Era of Psychedelic Research
    0:09:33 When the CIA Weaponized LSD for Mind Control
    0:13:10 Half a Pound of Mescaline and Ten Years to Recover
    0:15:09 The Day a Stranger Said "There's This Drug Called Adam"
    0:15:56 MDMA Was a Therapy Drug Before It Was Ecstasy
    0:18:39 Sasha Shulgin, the Man Who Invented 200 Psychedelics
    0:24:12 How Dealers Tweaked Molecules to Stay Legal
    0:27:21 Why Nixon Really Criminalized the Hippies
    0:30:04 Going to War With the DEA — and Winning
    0:33:56 Founding MAPS and $200 Million Later
    0:39:09 Taxing the Ecstasy Dealers to Fund the Lawsuit
    0:41:33 The First MDMA Safety Study, Run on a Beach
    0:42:43 The 1992 Moment That Reopened Psychedelic Science
    0:44:31 The First PTSD Study, Shut Down for Politics
    0:48:08 Cannabis Is Palliative, Psychedelics Are Curative
    0:50:08 The Veteran Suicide Epidemic Nobody Will Fund
    0:53:33 Why MAPS Bet Everything on MDMA
    0:58:35 The Effect Sizes That Should Have Changed Everything
    1:01:01 Why Half of Veterans Quit Standard PTSD Therapy
    1:02:13 Why the Data Alone Was Never Going to Win
    1:04:54 The Absurd Reason the FDA Cited: "Euphoria"
    1:06:34 Why You Can't Get Hooked on MDMA
    1:07:26 More Jail for MDMA Than for Cocaine
    1:08:36 Net Zero Trauma by 2070
    1:10:47 MDMA for Couples, and Bringing It to the World...
    ... Email for sponsorship enquiries:evan@thegiantsshoulder.com
    Guest Links
    Rick Doblin — MAPS: https://maps.org/people/rick-doblin/
    Rick Doblin on X: https://x.com/RickDoblin
    MAPS: https://maps.org
  • Giants Shoulder

    #132 - Meet the Psychedelic Scientist Proving The Fields Largest Theory is WRONG!

    25/06/2026 | 1h 46 mins.
    Check out Scispace (Use Code JNGIANT20: 20% OFF MONTHLY): https://scispace.com/?via=jun1giantshoulder
    Get Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulder
    Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about
    Manoj Doss is a cognitive neuroscientist and one of the only people studying what psychedelics actually do to memory — trained inside the field's most prestigious lab at Johns Hopkins, he's now its most rigorous internal sceptic. His claim is heretical: the profound sense of revelation you get on a trip may be a memory glitch — a familiarity signal firing without the detail that would normally justify it, so the trip feels like downloading the truth while your brain quietly degrades what it's actually recording.
    Expect to learn why the profound insights you get on psychedelics might be a memory glitch, why the entire default mode network story "needs to go to hell", what a 250-subject mega-analysis revealed that small studies missed, why salvia melts you into the couch while DMT builds whole worlds, whether DMT entities and mantises are real contact or just a brain built to see faces, why blocking a single receptor proves psychedelics aren't "keys to reality", the flaw Doss says sinks the entropic brain and REBUS, how you'd ever tell a true revelation from a beautiful lie, and much more…
    Timestamps
    0:00:00 Trailer
    0:02:24 The One Thing Psychedelic Science Ignores: Memory
    0:05:38 Why Your Worst Beliefs Feel Like Hard Facts
    0:07:38 The "Sense of Knowing" That Fools Everyone
    0:09:00 How Psychedelics Rewire What You Remember
    0:16:11 Why Yoga Feels Better on Psilocybin
    0:20:27 "The Default Mode Network Story Needs to Go to Hell"
    0:27:26 How Neuroscience Invents Stories From Noise
    0:35:42 Why Psychedelic Studies Are Too Small to Trust
    0:40:31 Salvia: Becoming a Sentient Piece of Corn
    0:44:13 The Kappa-Opioid Door Into Another Reality
    0:48:00 Why Salvia Is Heaven and Ibogaine Is Hell
    0:53:03 Does the Brain Have Two Reality Generators?
    0:59:24 Has 20 Years of Psychedelics Taught Us Anything?1:05:18 Are DMT Entities Real? The Mantis Problem
    1:13:28 Why You See Machine Elves (But His Mum Wouldn't)
    1:24:29 Tearing REBUS and the Entropic Brain Apart
    1:36:21 "Do Stuff in the Scanner, Stuff Happens in the Brain"
    1:44:25 The Debate Robin Was Warned Not to Do...
    ...
    Email for sponsorship enquiries: evan@thegiantsshoulder.com

    GS Episodes Mentioned
    Karl Friston — Meet The Neuroscientist Who Created The Best Universal Theory Of Brain Function: https://www.youtube.com/watch?v=R-IZOFs4qmY
    Robin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://www.youtube.com/watch?v=t-GkE4YtLRk
    Michael Levin — Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://www.youtube.com/watch?v=LTBZRVKUwyM
    Christof Koch — The Psychedelic Trip that Convinced Christof Koch Consciousness is Fundamental: https://www.youtube.com/watch?v=kJlV-b2bvaE
    David Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5o
    Guest Links
    Manoj Doss — Dell Medical School: https://dellmed.utexas.edu/directory/manoj-dossX (Twitter): https://x.com/manojdossGoogle Scholar: https://scholar.google.com/citations?user=KFo44R0AAAAJORCID: https://orcid.org/0000-0003-2939-2522
  • Giants Shoulder

    #131 Neuroscientist Ranks Every Drug By How Hard They Are to Quit! Tier List Part 3

    23/06/2026 | 1h 5 mins.
    Check out Scispace (JNGIANT20: 20% off the monthly plan or JNGIANT40: 40% off the annual plan): https://scispace.com/?via=jun1giantshoulder
    Professor David Nutt is a neuro­psychopharmacologist, former UK chief drug adviser, and author of Drugs Without the Hot Air, Drink?, Cannabis, and Psychedelics. After two rounds that sparked an overwhelming response, round three goes fringe — ibogaine, salvia, mescaline, peyote, GHB, xylazine, the nitazines, and the Amanita muscaria "Santa Claus" mushroom — ranking each on Nutt's evidence-based harm scale.
    Timestamps:
    2:56 Ibogaine
    7:21 Salvia
    18:02 Mescaline & Peyote
    23:59 San Pedro Cactus
    28:55 GHB40:59 Kratom & 7-Hydroxy
    46:05 Xylazine ("Tranq")
    51:34 Nitazines
    54:53 Amanita Muscaria
    ...
    Email for sponsorship enquiries: evan@thegiantsshoulder.com
    Buy Nutt's BooksDrink?: The New Science of Alcohol and Your Health: https://amzn.to/4dZTP9Z
    Psychedelics: The Revolutionary Drugs That Could Change Your Life―A Guide from the Expert: https://amzn.to/3SJXAX6
    Drugs without the hot air: Making sense of legal and illegal drugs: https://amzn.to/4kyu7eS
    Cannabis (Seeing Through the Smoke): The New Science of Cannabis and Your Health: https://amzn.to/3FOiLo2
    Check out the amazing work of Drug Science
    (Dr David Nutt's Charity)Website - https://www.drugscience.org.uk/Prof Nutt Twitter (X) - @ProfDavidNutt
    Drug Science SocialsFacebook - @DrugScienceISCDTwitter (x) - @drug_scienceInstagram - @drugscienceinfoLinkedIn - @drugscience-ltdBlueSky - @drugscience.bsky.socialYouTube - @DrugScienceMore Resources on Drug Safety
    Medical Cannabis: https://www.drugscience.org.uk/medical-cannabis-working-group
    Medical Psychedelics: https://www.drugscience.org.uk/medical-psychedelics-working-group
    Harm Reduction: https://www.drugscience.org.uk/enhanced-harm-reduction-working-groupAcademic Research: https://www.drugscience.org.uk/research
  • Giants Shoulder

    #130 - The Two Greatest Living Psychedelic Scientists Discuss The Insane Future Of Drugs

    18/06/2026 | 1h 50 mins.
    Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqe
    Get Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulder
    Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about
    David Nichols is the chemist who made the molecules behind the entire psychedelic renaissance; Bryan Roth is the pharmacologist who cracked how those drugs actually work inside the brain. Together they reveal how little we still understand about the compounds now entering mainstream medicine — and how the same technology could, in Roth's own words, build a literal zombie apocalypse.
    Expect to learn why the word "psychedelic" could once kill a research grant, how Nichols hand-made the MDMA, DMT and psilocybin behind the field's most famous trials, what profiling 41 psychedelics against 318 receptors actually revealed, why we still don't know what half of those receptors even do, whether the trip itself is the medicine or a side effect that can be engineered away, why a twitching mouse is the most reliable predictor of a human trip, how Roth's "remote control for neurons" could rewrite memory, pain and aggression, and much more…
    Timestamps
    0:00:00 Trailer
    3:22 Two Godfathers of Psychedelics, Together
    4:03 The Man Who Made the Molecules by Hand
    7:34 How Roth Fell Into Serotonin by Accident
    16:46 When "Psychedelic" Was a Forbidden Word
    20:18 318 Receptors, 41 Psychedelics: The Big Paper
    31:18 Nobody Knows What Half These Receptors Do
    35:46 How Nixon's Drug War Killed the Science
    46:06 The LSD in the Famous Structure Was Dave's
    55:52 1.4 Kilos of MDMA for $4,000
    57:29 The Psilocybin That Stunned Johns Hopkins
    1:00:19 The Real-Life Walter White
    1:01:20 Where Psychedelic Medicine Goes Next
    1:07:13 "It's Just GQ": How Psychedelics Actually Work
    1:11:35 The Hidden Proteins Behind Mental Illness
    1:20:03 Is the Trip Itself the Medicine?
    1:34:33 Why a Twitching Mouse Predicts a Trip
    1:38:14 Your Personalised Psychedelic, Designed by AI
    1:45:51 The Tech to Build a Zombie Apocalypse
    ...

    Email for sponsorship enquiries: evan@thegiantsshoulder.com

    GS Episodes Mentioned
    David Nichols — Meet The Greatest Living Psychedelic Scientist You've Never Heard Of: https://www.youtube.com/watch?v=6umTgXsW1lQ
    Bryan Roth — Meet The World's Greatest Psychedelic Receptor Scientist: https://www.youtube.com/watch?v=sEmmmMma8QsGuest Links
    Bryan Roth — UNC Pharmacology: https://www.med.unc.edu/pharm/directory/bryan-roth-md-phd/Roth Lab & NIMH Psychoactive Drug Screening Program: https://pdspdb.unc.edu/rothlab/
    David Nichols — Heffter Research Institute: https://www.heffter.org
    The 318-receptor psychedelics paper (Neuron, 2025): https://www.cell.com/neuron/abstract/S0896-6273(25)00470-2
More Life Sciences podcasts
About Giants Shoulder
A Biology & Consciousness podcast chronically the bio-singularity. Three times per week I speak with leading scientists at the bleeding edge of AI synthetic biology, consciousness & inner experience, genetics, psychedelics and drug science. Giants Shoulder is intended to be accessible & entertaining for all ages. No idea is too strange, tackled with genuine curiosity and technical rigour. Come follow the journey as I have my brain melted and ontology warped on a regular basis. Evan has a Neuroscience degree from Trinity College Dublin and is founder of Giants Shoulder.
Podcast website

Listen to Giants Shoulder, How We're Wired and many other podcasts from around the world with the radio.net app

Get the free radio.net app

  • Stations and podcasts to bookmark
  • Stream via Wi-Fi or Bluetooth
  • Supports Carplay & Android Auto
  • Many other app features