The Optispan Podcast with Matt Kaeberlein

• The Dangerous Truth About The Peptide Craze (I Tried It)

  This podcast episode is part three of a travel series where Matt recounts his recent trips to longevity and healthspan conferences in Geneva, Chicago, and Mauritius. He shares his experiences with jet lag, workouts, and the contrasting cultures of these events, from the more "alternative medicine" feel of the Geneva summit to the more scientifically-grounded Mauritius conference. A major theme is his critique of the current state of the longevity field, where he advocates for evidence-based approaches and calls out what he sees as misinformation, specifically regarding the overhyping of peptides, stem cells, and the misuse of epigenetic "aging clocks."This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

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• New Discovery: This Molecule Could Beat Rapamycin in Longevity

  Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Dive into the future of longevity research with Dr. Ben Blue, CEO of Ora Biomedical. We explore how Ora's high-throughput "Wormbot" platform is conducting the world's largest unbiased search for longevity interventions, moving beyond the narrow focus on established pathways like mTOR.In this episode, we discuss:• The ambitious Million Molecule Challenge and why it could revolutionize the field.• Surprising discoveries already made, including molecules that outperform rapamycin.• Ora's strategic pivot to radiation resistance, with applications for astronauts, pilots, and human health.• How their data-driven approach is uncovering interventions for resilience against toxins and other stresses.• The journey from worm models to potential clinical trials and what's next for the company.Learn how Ora is scaling drug discovery to tackle aging and age-related diseases.https://orabiomedical.com/https://x.com/OraBiomedical  / ora-biomedical-inc  This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps00:00 – Intro01:13 – Welcome & Disclosure02:40 – Ora Biomedical & the Longevity Mission04:04 – How the Wormbot Was Born06:43 – Matt's Perspective on the Wormbot09:22 – Automating Lifespan Experiments at Scale12:29 – The Million Molecule Challenge15:03 – Success Stories from the Challenge16:10 – A Better mTOR Inhibitor Than Rapamycin19:05 – Ora's Molecule Beats Rapamycin20:08 – 60% Lifespan Extension Discovery24:03 – Ivermectin & Surprising Findings24:55 – From Longevity to Anti-Parasite Drugs31:09 – Hot Take: Discovery vs. Mechanism35:22 – The Million Molecule Challenge Database40:45 – Radiation Resistance: A New Focus44:57 – Space Travel & Longevity Medicine49:18 – Testing Resilience to Toxins & Stress56:54 – What Thousands of Tests Reveal About Aging Pathways01:00:41 – False Positives vs. False Negatives in Screening01:04:45 – Skin Health & Anti-Aging Potential01:07:59 – What's Next for Ora BiomedicalDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

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• Matt's Thanksgiving Message

  Happy thanksgiving from the Optispan Team!

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• Longevity Problem: 70% Of All Deaths Are Caused By Aging - Dr. Andrew Steele

  Longevity scientist Dr. Andrew Steele sits down with Dr. Matt Kaeberlein to make the provocative case that aging should be treated as humanity's greatest challenge, even bigger than climate change. In this deep conversation, they explore why two-thirds of all deaths are caused by aging, the cutting-edge science that's already extending healthy lifespan in animals, and what it would really mean to add decades of vitality to human life. From CRISPR gene therapies to senescent cell clearance, from the ethics of radical life extension to practical steps you can take today, this is an unflinching look at whether we can (and should) slow down aging itself.Timestamps00:00 – Why Aging Is the Biggest Problem We’re Not Solving01:33 – Is Aging Actually Fixable? What the Science Shows04:01 – Overpopulation Myths vs. Longevity Reality09:02 – Can We Slow Aging? What’s Working Now14:39 – Inside the Longevity Divide: Hope vs. Hype18:45 – Healthspan vs. Lifespan: What Really Matters29:12 – Chronic Disease and the True Cost of Aging36:21 – The Most Promising Longevity Therapies Today56:56 – Biological Age Tests: What You Can Actually Trust01:53:17 – The Future of Longevity: AI, Innovation, and What’s NextConnect with Dr. Andrew SteeleWebsite: https://andrewsteele.co.uk/YouTube:    / drandrewsteele  Instagram:   / andrewjsteele  Twitter:   / statto  LinkedIn:   / andrewsteele  Bluesky: https://bsky.app/profile/statto.bsky....Mastodon: https://mas.to/@stattoThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

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• Scientist Reacts: Why Megadosing Creatine Is A Waste Of Time

  Creatine is being called a "cognitive super-drug" that feels like "speed without the speed." Influencers are telling you to mega-dose 20 grams a day for brain power, bone health, and more. But what does the science actually say?In this episode, we go beyond the hype and fact-check the wildest creatine claims taking over the internet. I break down the real evidence on mega-dosing, and put the cognitive benefits to the testI react to clips from Paul Saladino, Jeff Cavalier, Rhonda Patrick, and Dave Asprey to separate proven fact from marketing fiction. Discover the simple, science-backed creatine protocol that actually works, and save your money (and your gut) in the process.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/00:01:23 - High-Level Reality Check on Creatine00:03:12 - Hosts' Personal Histories with Creatine00:05:17 - How to Evaluate Health Influencers & Their Claims00:08:40 - Paul Saladino (MD): Analysis of Mega-Dosing Claims (20g/day) for Brain & Bones00:23:16 - Jeff Cavaliere (Physical Therapist): Claims on Depression, Parkinson's, and MS00:31:22 - Discussion on Creatine for Sleep Deprivation & High Stress00:34:28 - The "No Downside" Myth & Side Effects (GI Issues, Microbiome)00:37:29 - Rhonda Patrick (PhD): "Feels Like Speed" Claim & Brain Aging00:46:00 - Dave Asprey: "Most Powerful Cognitive Drug" Claim00:53:02 - How Creatine Actually Works (The "Backup Battery" Analogy)00:53:49 - Final Take-Home Messages & Summary00:56:00 - Q&A: Best Time to Take Creatine & What to Do If You Miss a Day00:57:42 - Final Thoughts on Influencer HypeDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/

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