The Optispan Podcast with Matt Kaeberlein

• Gut Health: Science-Backed Tips For Leaky Gut, IBS, & Your Microbiome | Dr. Mary Pardee

  Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Mary Pardee sit down to discuss insights on gut health, digestion, and common GI issues like IBS and constipation. This video covers practical approaches to improving gut function, debunking myths, and identifying effective solutions for long-term wellness, all while attempting to separate fact from fiction in the world of gut health.0:00 - Introduction to Gut Health & Microbiome1:47 - IBS and Digestive Health: How It's Diagnosed & Treated3:04 - The Truth About Microbiome Testing: Myths vs. Science6:36 - FDA & Direct-to-Consumer Microbiome Tests: Are They Reliable?11:44 - Probiotics: Do They Work & Who Should Take Them?16:05 - IBS Treatment: Lifestyle, Diet, and Medications24:26 - Diets & Gut Health: Keto, Carnivore, & Plant-Based Comparisons32:04 - Supplements for Gut Health: What Works & What’s Overhyped?56:26 - Cardiovascular Screening: Coronary Calcium Score vs. Clearly Scan1:12:32 - Supplements: What’s Worth Taking & What’s a Waste of Money?Producers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

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• The Truth About Biological Age Tests | 104

  Subscribe to our channel: https://www.youtube.com/@optispanMatt Kaeberlein dives into the controversial world of biological age tests. Many direct-to-consumer tests claim to measure your biological age, but are they accurate or useful? Based on extensive research and clinical experience, we uncover why these tests are statistically meaningless, lack regulatory validation, and fail to provide actionable health insights. Instead, we highlight proven biomarkers that actually contribute to longevity and well-being. If you're considering spending money on a biological age test, watch this first!In this episode of the Optisan Podcast, we dive into the controversial world of biological age tests. Many direct-to-consumer tests claim to measure your biological age, but are they accurate or useful? Based on extensive research and clinical experience, we uncover why these tests are statistically meaningless, lack regulatory validation, and fail to provide actionable health insights. Instead, we highlight proven biomarkers that actually contribute to longevity and well-being. If you're considering spending money on a biological age test, watch this first!0:00 - Introduction & Overview1:09 - Why Biological Age Tests Are Misleading2:26 - Optisan’s Research on Biological Age Tests4:40 - Understanding Biological Age Clocks & Their Limitations6:34 - The Four Major Problems with These Tests7:57 - Lack of Regulatory Approval & Oversight10:28 - Are Doctors Benefiting from These Tests?12:22 - Reliable Biomarkers for Longevity & HealthProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

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• Dr. Kevin White: Concierge Medicine & Its Impacts On Living Longer & Healthier Lives | 103

  Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We discuss the costs, the role of insurance, advanced diagnostics, and the future of AI in concierge medicine.0:00 - Intro & Concierge Medicine Overview3:15 - How Concierge Medicine Differs from Primary Care9:40 - Benefits of Personalized Doctor Access15:20 - Costs, Insurance, & Payment Options21:05 - Longevity & Proactive Health Strategies28:35 - Advanced Testing & Diagnostics in Concierge Care35:50 - AI & Technology in Concierge Medicine42:10 - How to Find a Good Concierge DoctorProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

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• Thomas Delauer: NEW Nutrition, Exercise, and Mindset Shifts In 2025 | 102

  Subscribe to our channel: https://www.youtube.com/@optispanThomas DeLauer & I (Dr. Matt Kaeberlein) discusses his evolving perspectives on nutrition, exercise, and health optimization. Thomas shares how his views on insulin, low-carb diets, and fructose have shifted, his approach to training for strength and longevity, and the importance of sleep, emotional well-being, and recovery. Delauer also touches on peptides, supplements, and wearable tech, providing valuable takeaways for those looking to improve their performance, body composition, and overall health.0:00 - Introduction & Thomas DeLauer’s evolving views2:10 - The challenge of simplifying health content4:57 - Shifting perspectives on nutrition & health goals7:55 - Low-carb lifestyle & insulin reconsidered12:49 - A day in the life: Diet, fasting & protein intake19:04 - Strength training, cardio & hybrid workouts25:45 - Sleep optimization & recovery strategies30:11 - Emotional health, connection & mindfulness36:02 - Peptides, supplements & risk vs. rewardProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

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  42:42
• My Biggest Health & Longevity Breakthroughs at 54 | 101

  Subscribe to our channel: https://www.youtube.com/@optispanI share the top health and longevity strategies that have transformed my energy, fitness, and well-being at 54 - From hormone optimization (TRT) and resistance training to diet improvements, alcohol reduction, and preventative diagnostics.0:00 - Reflections on Turning 54 & Longevity Mindset1:42 - Hormone Optimization: The Biggest Game-Changer3:28 - Diet & Alcohol Reduction: Key Health Improvements4:56 - Exercise & Resistance Training for Longevity9:10 - Preventative Diagnostics & Biomarkers Matter16:46 - Relationships & Mental Well-Being in HealthProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

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