The Thyroid (and Hormone) Fixer Podcast: Thyropause, Menopause, Metabolism and How to Fix It

What if Alzheimer's doesn't begin when you start forgetting things, but decades earlier, with your blood sugar, your waistline, and your hormones? In this episode, I'm joined by Dr. David Perlmutter, Board-Certified Neurologist and author of Grain Brain and his new book, Brain Defenders, to unpack why your brain's future is something you can influence. We talk about microglia, the brain's own immune cells, how they shift from protecting your brain to damaging it, and why chasing beta amyloid may be missing the bigger picture.
We also get into how thyroid hormone, especially T3, fuels the mitochondria that help keep those immune cells supportive. We look at why the drop in estrogen during perimenopause may help explain why two-thirds of Alzheimer's patients are women. Dr. Perlmutter shares where he stands on hormone replacement therapy and testosterone and what the research says so far about GLP-1 medications and brain health. He also names the labs he wants everyone in their 30s, 40s, and 50s to know, including fasting insulin, A1C, and homocysteine.
What you'll learn:
Why Alzheimer's may begin decades before memory loss shows up
Why Dr. Perlmutter says carrying the APOE4 gene variant means predisposed, not predetermined
What microglia are and how they shift from supportive to destructive
How blood sugar, gut inflammation, and head trauma can all affect your brain's immune cells
How thyroid hormone and your mitochondria work together to support brain energy
Why falling estrogen during perimenopause may put women's brains at greater risk
Where Dr. Perlmutter stands on hormone replacement therapy and testosterone
What the research says so far about GLP-1 medications and the brain
Tune in to learn how to start protecting your brain now, long before any symptoms show up.
Resources from Dr. David Perlmutter:
Brain Defenders (book): https://braindefenders.com 
Website: https://drperlmutter.com 
Podcast: The Empowering Neurologist
Follow Dr. Perlmutter on social media:
Instagram: @davidperlmutter
Youtube: https://www.youtube.com/user/DavidPerlmutterMD 
X: @davidperlmutter 
Linkedin: linkedin.com/in/david-perlmutter-md 
Grab your Thyroid Fixer here: https://betterlifedoctor.com/
New here? Use code LISTEN20 for 20% off your first order
Returning customers can use code LISTEN10 for 10% off
SHOP DR. AMIE'S FIXXR® SUPPLEMENTS:
betterlifedoctor.com 
LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman
Book a free thyroid and hormone solution call:
https://dramiehornaman.com/pages/book-a-call 
CHECK OUT MY FREEBIES... JUST CLICK BELOW
Thyroid Optimization Guide: https://health.dramie.com/thyropause 
7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter 
Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin 
RATE, REVIEW AND FOLLOW ON APPLE PODCASTS
Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you're enjoying our journey together, I'd be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click HERE: (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review.
Haven't subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow HERE: (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey!
CONNECT WITH ME ON SOCIAL MEDIA:
Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey.
https://www.facebook.com/groups/dramie/ 
Like me on Facebook: Amie Hornaman Nutrition and Functional Medicine (https://www.facebook.com/amiehornamannutrition/) 
Subscribe on YouTube: Dr. Amie Hornaman (https://www.youtube.com/c/dramiehornaman) 
Follow me on Instagram: @dramiehornaman (https://www.instagram.com/dramiehornaman/) 
Disclaimer: Information provided on The Thyroid Fixer® podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem.

Gut health is about far more than bloating and constipation. In this episode, I’m joined by Laura Frontiero to unpack the overlooked ways gut dysfunction can show up, from fatigue and brain fog to skin issues, joint pain, sleep problems, and thyroid challenges. We also talk about why common gut protocols don’t always work and why the order in which you address gut health matters.

We connect the dots between the gut, thyroid function, nutrient absorption, hormone clearance, toxins, infections, and chronic stress. Laura also breaks down the four areas she looks at when working with gut health and why supporting the body before jumping into probiotics or other protocols can make such a difference.

What you’ll learn:

Why gut problems don't always cause digestive symptoms

Why probiotics aren't always the best place to start

How gut health and thyroid function influence each other

The connection between toxins and nutrient deficiencies

What chronic stress has to do with gut restoration

Why digestion and stomach acid matter for thyroid health

How hormone clearance is connected to the gut

Why the order of your approach matters

Tune in to learn how to recognize the less obvious signs of gut dysfunction, understand the connection between your gut and thyroid, and rethink the way you approach gut health.

Resources:

Join Laura’s Gut Health Masterclass: https://flatterbellylive.com/join?am_id=jayme8792&utm_source=dramie

Grab your Thyroid Fixer here: https://betterlifedoctor.com/

New here? Use code LISTEN20 for 20% off your first order

Returning customers can use code LISTEN10 for 10% off

SHOP DR. AMIE’S FIXXR® SUPPLEMENTS:

betterlifedoctor.com 

LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman

Book a free thyroid and hormone solution call:

https://dramiehornaman.com/pages/book-a-call 

CHECK OUT MY FREEBIES... JUST CLICK BELOW

Thyroid Optimization Guide: https://health.dramie.com/thyropause 

7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter 

Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin 

RATE, REVIEW AND FOLLOW ON APPLE PODCASTS

Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you’re enjoying our journey together, I’d be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review.

Haven’t subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey!

CONNECT WITH ME ON SOCIAL MEDIA:

Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey.

⁠https://www.facebook.com/groups/dramie/⁠ (https://www.facebook.com/groups/dramie/) 

Like me on Facebook:⁠Amie Hornaman Nutrition and Functional Medicine⁠ (https://www.facebook.com/amiehornamannutrition/)

Subscribe on YouTube:⁠Dr. Amie Hornaman⁠ (https://www.youtube.com/c/dramiehornaman)

Follow me on Instagram:⁠@dramiehornaman⁠ (https://www.instagram.com/dramiehornaman/)

What if the best biohacks are actually the simplest ones? In this episode, I’m breaking down the tools I genuinely believe are worth considering, from sleep, strength training, and pain management to cleaner air and water, red light therapy, sauna, and frequency-based technologies.
I also talk about where more advanced options like stem cells, exosomes, and PRP fit in, and the question I use to evaluate any biohacking tool: Does it actually help my body function better, or does it just give me more to track?
What you’ll learn:
Why sleep is the foundation of biohacking
Which simple environmental changes can make a difference
What makes red light therapy worth considering
Why pain relief and mobility deserve more attention
Where sauna and frequency technologies fit
What I think about regenerative therapies
Why strength training may be the ultimate biohack
How to know when a biohack is actually worth it
If you’ve ever felt overwhelmed by the endless options, gadgets, and advice in the biohacking world, this episode will help you sort through what’s actually worth your time and attention. 
Resources:
Grab your Thyroid Fixer here: https://betterlifedoctor.com/
New here? Use code LISTEN20 for 20% off your first order
Returning customers can use code LISTEN10 for 10% off
SHOP DR. AMIE’S FIXXR® SUPPLEMENTS:
betterlifedoctor.com 
LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman
Book a free thyroid and hormone solution call:
https://dramiehornaman.com/pages/book-a-call 
CHECK OUT MY FREEBIES... JUST CLICK BELOW
Thyroid Optimization Guide: https://health.dramie.com/thyropause 
7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter 
Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin 
RATE, REVIEW AND FOLLOW ON APPLE PODCASTS
Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you’re enjoying our journey together, I’d be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review.
Haven’t subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey!
CONNECT WITH ME ON SOCIAL MEDIA:
Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey.
⁠https://www.facebook.com/groups/dramie/⁠ (https://www.facebook.com/groups/dramie/) 
Like me on Facebook:⁠Amie Hornaman Nutrition and Functional Medicine⁠ (https://www.facebook.com/amiehornamannutrition/)
Subscribe on YouTube:⁠Dr. Amie Hornaman⁠ (https://www.youtube.com/c/dramiehornaman)
Follow me on Instagram:⁠@dramiehornaman⁠ (https://www.instagram.com/dramiehornaman/)

What happens when biohacking stops being about improving your health and starts costing you money, creating more stress, and taking you away from your actual life? In this episode, I’m calling out the biohacking bullshit that has gone too far, from endless supplements and peptides to CGMs, cold plunges, expensive devices, whole-body MRIs, biological-age testing, and the pressure to constantly optimize another metric. Just because something is expensive, high-tech, or backed by some scientific mechanism doesn’t mean it is actually solving your problem.
I’m not anti-biohacking. I use some of these tools myself. The issue is what happens when we start using the 5% to avoid the 95% that actually matters: sleep, nutrition, movement, muscle, stress, relationships, and addressing underlying physiology. I break down the five questions I want you to ask before spending another dollar on a biohacking intervention and why the ultimate measure of health may have less to do with your readiness score or biological age and more to do with whether you have the energy and freedom to enjoy your life.
What you’ll learn:
The hidden costs of taking biohacking too far
How fear can drive unnecessary health spending
When health tracking starts creating more stress than value
What to consider before spending thousands on peptides, devices, or testing
Why more data doesn't automatically mean better health
How optimization can start interfering with food, family, and everyday life
Why the basics still matter more than the latest biohacking trend
The five questions to ask before trying your next biohack
If you’ve been caught up in the pressure to constantly optimize your health, this conversation will give you a different way to think about what is actually worth your time, money, and attention.
Resources:
Grab your Thyroid Fixer here: https://betterlifedoctor.com/
New here? Use code LISTEN20 for 20% off your first order
Returning customers can use code LISTEN10 for 10% off
SHOP DR. AMIE’S FIXXR® SUPPLEMENTS:
betterlifedoctor.com 
LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman
Book a free thyroid and hormone solution call:
https://dramiehornaman.com/pages/book-a-call 
CHECK OUT MY FREEBIES... JUST CLICK BELOW
Thyroid Optimization Guide: https://health.dramie.com/thyropause 
7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter 
Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin 
RATE, REVIEW AND FOLLOW ON APPLE PODCASTS
Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you’re enjoying our journey together, I’d be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review.
Haven’t subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey!
CONNECT WITH ME ON SOCIAL MEDIA:
Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey.
⁠https://www.facebook.com/groups/dramie/⁠ (https://www.facebook.com/groups/dramie/) 
Like me on Facebook:⁠Amie Hornaman Nutrition and Functional Medicine⁠ (https://www.facebook.com/amiehornamannutrition/)
Subscribe on YouTube:⁠Dr. Amie Hornaman⁠ (https://www.youtube.com/c/dramiehornaman)
Follow me on Instagram:⁠@dramiehornaman⁠ (https://www.instagram.com/dramiehornaman/)

What does the research actually tell us about T2, the often-overlooked thyroid hormone? In this episode, I break down the science behind T2, from animal research on metabolism and fat browning to the limited human studies available, including a 2011 study that found changes in resting metabolic rate and body weight.
I also share the results of our own 14-week trial involving 14 women with different thyroid and hormonal profiles. We look at what happened, what surprised me most, how the findings influenced our dosing approach, and where more research is still needed.
What you’ll learn:
Why researchers are interested in T2 and metabolism
What animal studies have shown about T2 and fat browning
What the limited human research tells us
What happened in our 14-woman trial
Why thyroid function made some of the results particularly interesting
What the findings changed about our dosing approach
What we still need to learn about T2
There’s a lot to be curious about when it comes to T2, but the research matters. Tune in as I walk through what we know, what we’ve seen firsthand, and what still needs to be studied.
Resources:
Grab your Thyroid Fixer here: https://betterlifedoctor.com/
New here? Use code LISTEN20 for 20% off your first order
Returning customers can use code LISTEN10 for 10% off
SHOP DR. AMIE’S FIXXR® SUPPLEMENTS:
betterlifedoctor.com 
LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman
Book a free thyroid and hormone solution call:
https://dramiehornaman.com/pages/book-a-call 
CHECK OUT MY FREEBIES... JUST CLICK BELOW
Thyroid Optimization Guide: https://health.dramie.com/thyropause 
7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter 
Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin 
RATE, REVIEW AND FOLLOW ON APPLE PODCASTS
Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you’re enjoying our journey together, I’d be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review.
Haven’t subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey!
CONNECT WITH ME ON SOCIAL MEDIA:
Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey.
⁠https://www.facebook.com/groups/dramie/⁠ (https://www.facebook.com/groups/dramie/) 
Like me on Facebook:⁠Amie Hornaman Nutrition and Functional Medicine⁠ (https://www.facebook.com/amiehornamannutrition/)
Subscribe on YouTube:⁠Dr. Amie Hornaman⁠ (https://www.youtube.com/c/dramiehornaman)
Follow me on Instagram:⁠@dramiehornaman⁠ (https://www.instagram.com/dramiehornaman/)