Dr. Steven Gundry: Is Fungus Secretly Running the World—and Your Gut? : 1270
If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours? In this mind-altering episode of The Human Upgrade, Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. From addiction and depression to obesity and inflammation, the microbes living in your gut—bacteria, fungi, viruses, even parasites—may be pulling the strings on your brain chemistry, mood, and behavior. Dave Asprey and Dr. Gundry dive deep into The Gut-Brain Paradox, exposing how the gut-brain axis operates more like a microbial command center than a digestive system. You’ll learn why probiotic pills rarely work, how the wrong microbes can drive compulsive behavior, and how toxic foods, glyphosate, and antibiotics have turned our guts into neurological war zones. Most shocking of all? Microbes may not just influence addiction—they may cause it. What You’ll Learn in This Episode: • How your gut microbiome can hijack your brain and influence your thoughts and behavior • Why certain microbes may actually cause addiction, obesity, and depression • How antibiotics, glyphosate, and processed foods are turning your gut into a desert • How to rebuild your gut ecosystem using postbiotics, fermented foods, and precision inputs • Why food cravings might be microbial mind control—and what to do about it • What the latest science reveals about the gut-brain axis, neurotransmitters, and neuroinflammation Sponsors: -Sunlighten | Go to https://www.sunlighten.com/dave/ and enter code DAVE at checkout to save up to $1,400. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dr. Gundry’s Instagram – https://www.instagram.com/drstevengundry/?hl=en • Dr. Gundry’s Website: https://drgundry.com/ • Dr. Gundry’s New Book The Gut-Brain Paradox: https://www.barnesandnoble.com/w/the-gut-brain-paradox-steven-r-gundry-md/1146019686?ean=9780062911803 • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 — Trailer • 02:01 — Intro • 03:55 — The Gut-Brain Connection • 04:45 — Microbiome Communication and Control • 08:19 — The Role of Fungi and Plants • 11:29 — Microbiome Diversity and Health • 19:05 — Addictive Microbiome and Behavior • 28:17 — Antibiotics and Gut Health • 30:49 — Listener Concerns and Gut Health • 31:02 — Whale Watching and Climate Change • 32:58 — Understanding SIBO and Bacterial Migration • 34:02 — The Role of Soluble Fiber and Fermented Foods • 36:12 — Complexity of Gut Microbiome • 36:49 — Restoring Ecosystems and Gut Health • 38:23 — Precision Microbiome Manipulation • 41:31 — Calcium Formation and Gut Bacteria • 43:56 — Oxalates vs. Lectins Debate • 46:04 — Whole Foods and Glyphosate Concerns • 51:47 — Dopamine Levels and Gut Health • 54:59 — Conclusion and Book Promotion See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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54:11
Longevity Scientists Discover a Breakthrough Peptide That Reverses Hair Loss | Carolina Reis Oliveira : 1269
If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong? For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real culprit behind age-related hair loss is cellular dysfunction? And what if we could change that? In this episode, Dave Asprey uncovers the cellular biology of hair thinning with longevity researcher Carolina Reis Oliveira. You’ll learn how senescent cells (aka zombie cells) hijack your scalp, disrupt follicle function, and silently accelerate hair loss—and how a breakthrough peptide might stop it cold. Carolina reveals brand-new clinical research on OS-01, a molecule shown to increase hair density by 40% in just 6 months. But this isn’t a product pitch—it’s a paradigm shift. Together, they explore the hidden drivers of hair aging, from hormone shifts and stress cascades to microbiome imbalances and inflammation, plus the real science behind what can actually regrow hair. What You’ll Learn in This Episode: • How “zombie cells” (senescent cells) sabotage your hair from the inside out • The science behind the OS-01 peptide and how it reverses visible hair thinning • Why thinning hair isn’t just genetic—and what else is driving it • How stress, hormones, and aging collide to trigger follicle dysfunction • What your scalp microbiome has to do with regrowth and hair density • How to stack red light, peptides, and topicals for real, measurable results ***Visit oneskin.co/DAVE and use code DAVE for and additional 15% off.*** Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • OneSkin Instagram – https://www.instagram.com/oneskin.co/ • OneSkin Website: https://www.oneskin.co/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 — Trailer • 01:52 — Intro • 02:59 — Is Aging Optional for Your Scalp? • 04:03 — Understanding Scalp and Hair Aging • 05:06 — The Role of Senescent Cells in Hair Loss • 07:25 — Hormonal Influences on Hair Health • 16:10 — Peptide Solutions for Hair Thinning • 18:05 — Clinical Studies and Results • 20:29 — Future of Hair Loss Treatments • 30:16 — Nutritional and Lifestyle Factors • 36:40 — Addressing Senescent Cells and Hair Growth • 37:29 — Minoxidil: Oral vs. Topical Use • 39:32 — Personal Experience with Hair Products • 40:25 — Combining Therapies for Hair Growth • 46:06 — Nutritional Factors in Hair Health • 52:20 — Sun Exposure and Hair Health • 56:40 — Coffee and Hair Growth • 01:00:01 — Launching the New Hair Product See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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59:55
Identity Hacker: How to Completely Change Your Personality at ANY Age | Olga Khazan : 1268
What if you could rewrite the code of your personality—on command? Not just cope with anxiety, overthinking, or social exhaustion… but delete the traits holding you back and install better ones? This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods, triggers, and even sense of self aren’t fixed—they’re fluid. And more importantly: they’re up for grabs. Joining him is award-winning journalist from The Atlantic, Olga Khazan, author of Me, But Better, who spent years hacking her own mind—transforming high neuroticism, social avoidance, and chronic self-criticism into calm, confidence, and connection. Her personal experiment in identity rewiring became a roadmap for anyone who wants to feel different… and live differently. You’ll uncover the hidden mechanisms behind neuroticism, reactivity, and emotional spirals—and how to override them with real-time upgrades. What You’ll Learn in This Episode: • Why your personality is a program—and how to recode it • What daily behaviors scientifically rewire anxiety, anger, and reactivity • The surprising link between identity, inflammation, and your gut • Why gratitude isn’t soft—it’s neurological jiu-jitsu • How to know if it’s your biology or your story running the show • Whether pills, psychedelics, or sleep do more to shift who you are • What to do when your inner critic won’t shut up • And how to stop being the person you never meant to become SPONSORS -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. Resources: • Olga’s New Book – Me, But Better: https://www.amazon.com/Me-But-Better-Science-Personality/dp/1668012545 • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Olga's Instagram – https://www.instagram.com/olganator/?hl=en • Olga’s Website: https://olgakhazan.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 0:00 — Trailer • 1:52 — Intro • 2:16 — Personality Changes and Neuroticism • 5:38 — Postpartum Personality Shifts • 10:21 — Gratitude and Cultural Beliefs • 18:13 — Anger Management and Empathy • 32:58 — Personality Traits and Boundaries • 35:46 — The Importance of Strong Boundaries • 36:07 — Personality Change as Self-Improvement • 37:22 — The Role of Medication in Personality Change • 39:18 — Brain-Body Connection and Mental Health • 43:26 — Impact of Sleep and Nutrition on Personality • 44:23 — Nicotine and Other Substances • 45:41 — Therapy and Personality Change • 46:43 — Changing Personality Through Behavior • 1:01:25 — The Role of Relationships in Personality Development • 1:04:49 — Challenges and Methods in Personality Change • 1:08:38 — The Power of Improv in Personality Change • 1:10:17 — Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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1:06:13
Psychedelic States On-Demand (No Substances Needed) | Dr. Patrick Porter : 1267
Your brain isn’t broken—it’s underpowered. Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price. In this episode, Dave sits down with Dr. Patrick Porter, founder of BrainTap, to reveal how to reprogram your brain using light, sound, and guided visualization—no substances, no side effects, no BS. Dr. Porter breaks down how to activate gamma brainwaves, repair trauma loops, access psychedelic-like states, and boost cognitive performance by 19% in just six weeks. You’ll learn why most brains burn out decades too soon—and how to charge yours back up. What You’ll Learn in This Episode: • How to flood your brain with energy and wake it up • The light and sound protocol that mimics psychedelics—safely • What gamma brainwaves unlock—and how to generate them on demand • Why your default mode network traps you in stress and distraction • The BrainTap protocol that improved cognition by 19% in 6 weeks • A real-life transformation story that rewrote one woman’s fate • The link between sleep, trauma, brain states, and performance • How to build a brain that performs like it’s decades younger This episode gives you a playbook to reclaim your focus, deepen your rest, and experience the full range of human consciousness—without touching a drug. Turn your brain on. Then turn it up. SPONSORS -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. -BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. Resources: • Biohacking Conference 2025 (May 28th-30th in Austin): https://biohackingconference.com/2025 (use code BRAINTAP to save 30% on General Admission and Virtual Tickets)• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • BrainTap Instagram: https://www.instagram.com/braintaptech/?hl=en • BrainTap Website: https://braintap.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 00:35 – Intro • 00:50 – Meet Dr. Patrick K. Porter and BrainTap • 01:28 – The Science Behind Light and Sound Therapy • 03:38 – Quantum Biology and Frequency Medicine • 04:32 – Enhancing Cognition with Sound and Light • 06:19 – Biohacking Conference Highlights • 08:07 – Transformative Stories and BrainTap Benefits • 17:54 – The Role of Gamma Waves and Psychedelics • 26:55 – Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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29:07
Why Gen Z Can’t Handle the Real World (and How We Can Help Them) | Jennifer Cohen : 1266
You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable. It feels like love. But what if it’s making them weak? In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert Jennifer Cohen to reveal how today’s parenting norms are quietly producing the most anxious, dependent, and emotionally fragile generation in history—Gen Z. Whether you’re raising kids, managing young employees, or trying to understand the next generation—you’ll walk away from this episode with a new lens on resilience, responsibility, and real-world readiness. What You’ll Learn in This Episode: • Why Gen Z struggles with anxiety, confidence, and failure • How smartphones, safe spaces, and overparenting weaken resilience • The science behind boredom, chores, and grit-building discomfort • Why participation trophies are doing real psychological harm • The bold parenting shifts that build strong, adaptable adults • How to model strength—even when it’s unpopular • The simple framework to raise kids who can thrive, not just survive If you want to raise strong kids—or work with a generation that’s struggling—this episode is a must-listen. It’s not just about parenting. It’s about the future. And it starts with getting uncomfortable. SPONSORS -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. Resources: • A Day of Biohacking and Consciousness Even (4/12): https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Jennifer’s Instagram: https://www.instagram.com/therealjencohen/ • Jennifer’s Podcast: https://www.youtube.com/channel/UCBuPgI8lXTmy5T0D_EDMnVg • Jennifer’s Website: https://www.jennifercohen.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 01:59 – Intro • 03:38 – The Shift in Parenting Styles • 07:04 – The Role of Technology and Social Media • 10:59 – The Importance of Failure and Resilience • 13:38 – Practical Parenting Tips and Challenges • 24:06 – The Value of Chores and Responsibility • 26:24 – Balancing Luxury and Adversity in Parenting • 27:01 – Teaching Kids to Embrace Failure • 28:00 – The 10% Target: Encouraging Persistence • 29:35 – The Importance of Boredom and Creativity • 30:58 – Role Modeling Healthy Habits • 31:43 – Kids’ Reactions to Fast Food • 32:49 – Extreme Parenting: Biohacking and Kids • 36:30 – Rejection Therapy and Boldness • 42:42 – Praising Effort Over Intelligence • 45:32 – Challenges of Being Attractive and Intelligent • 49:31 – Instilling Self-Esteem in Children • 50:13 – Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
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