The Human Upgrade: Biohacking for Longevity & Performance

• What If You Stop Eating For 72 Hours? : 1375

  Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?In this video, Dave Asprey breaks down what really happens when you fast for 3 days—and why short fasts don’t reach the deep repair zone your body is built for. You’ll learn:The 3 critical stages your body passes through during fastingHow autophagy turns on and begins cellular repairWhat mistakes destroy your progress (like bad refeeding or skipping electrolytes)How to properly prepare, fast, and recover safelyWhy fasting can make your mitochondria stronger, your mind sharper, and your cells younger*** Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide. ***Timestamps 0:00 - Why 16-hour fasts don’t reach real fat burning0:54 - The myth of aging and what doctors overlook1:48 - How modern life damages your mitochondria2:48 - How fasting restores your body’s repair mode3:39 - Understanding the phases of fasting4:58 - Why short fasts cut results short5:34 - Day 1 of fasting6:45 - Day 2 of fasting7:22 - Day 3 of fasting8:24 - Common fasting mistakes that harm your body9:35 - How to prepare before your fast10:31 - The right way to refeed afterward11:14 - Listening to your body’s signals and responsesThank you to our sponsors! -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  --------  

  12:08

  --------

  12:08
• The Real Reason Your Face Is Aging So Fast : 1376

  Vitamin C, copper peptides, and glutathione behave very differently once you understand how skin absorbs nutrients at the cellular level. This episode shows you how to target collagen production, strengthen mitochondria, improve detox capacity, and upgrade skin density with pharmaceutical grade delivery systems that outperform conventional skincare. You learn why most topical antioxidants never reach their intended targets, how intracellular copper changes longevity pathways, why glutathione affects everything from pigmentation to detox, and how to build a streamlined routine that matches the way high level biohackers actually age. These strategies can help you improve collagen, elasticity, hair density, mitochondrial function, and whole body performance with fewer steps and far more impact. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Dr. Nayan Patel, a pharmacist, wellness expert, and industry leader who has worked with physicians since 1999 to design custom medications and patient specific protocols. He has been the pharmacist of choice for celebrities, CEOs, and medical professionals seeking precision level formulations. Dr. Patel is the author of The Glutathione Revolution, which summarizes more than a decade of clinical research on glutathione. His team created a patented transdermal technology that delivers glutathione systemically through the skin, and he has since expanded this work to include advanced peptides and new delivery systems that improve absorption far beyond standard topical products. He also developed the Auro GSH Antioxidant Delivery System, a skincare line that uses pharmaceutical grade ingredients at potent concentrations to achieve deeper penetration and more reliable biological effects. Together they break down why vitamin C acts as a stimulant that drives collagen rather than a classic antioxidant, how GHK copper peptide thickens aging skin, and why retinoids often speed up cell turnover at the cost of long term resilience. Dr. Patel explains the difference between cosmetic grade and injectable grade peptides, why purity matters when a delivery system pushes molecules deep into the skin, and how zinc overuse has created widespread copper deficiency that affects hair, metabolism, and mitochondrial health. Dave shares his own protocols for using GHK, glutathione, and vitamin C, along with practical dosing strategies that create visible changes in skin density within four to six weeks. You will learn: • How vitamin C stimulates collagen and why glutathione regenerates oxidized antioxidants • How GHK copper peptide improves elasticity, firmness, and structural integrity • Why purity, molecular size, and delivery tech determine whether peptides actually reach target tissues • How topical copper supports intracellular stores and influences hair health and metabolism • Why zinc overload causes silent copper deficiency and what it means for longevity • How targeted glutathione improves detox, pigmentation, and oxidative stress • The fastest protocol for visible skin density improvements and how long results take to show • How to combine these tools with lasers and skin procedures for stronger outcomes Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: GHK copper peptide, topical glutathione delivery, dextrin absorption technology, intracellular copper uptake, vitamin C collagen stimulation, antioxidant regeneration, cosmetic peptide purity, injectable grade peptides, zinc copper imbalance, mitochondrial skin health, hair follicle regeneration, oxidative stress reduction, glutathione detox support, peptide based skincare, collagen crosslinking support, DMAE skin firmness, CoQ10 topical benefits, skincare biohacking, longevity dermatology, pharmaceutical transdermal systems Resources: • Go to https://aurowellness.com/ ‘DAVE10’ for a discount! • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:30 - Introduction 5:51 - Delivery Technology and How It Works 9:34 - Product Development and Formulations 21:29 - Application and Usage Guidelines 32:17 - Hair Growth and Specific Concerns 37:22 - Copper, Deficiency and Body Systems 40:52 - Special Topics and Protocols 52:00 - Dosing Protocols and Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  --------  

  57:18

  --------

  57:18
• Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374

  If you care about longevity, mitochondria, cardiovascular health, or feeling sharper every day, this episode gives you a clear look at the breakthrough technology that could reshape how supplements are made. Host Dave Asprey talks with Ilan Sobel, CEO of BioHarvest Sciences, about a new way to produce plant compounds at industrial scale without ever growing the plant. Their Botanical Synthesis platform creates highly pure, clinically validated molecules that support blood flow, brain function, metabolic health, and cellular energy with remarkable consistency and little to no environmental waste. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Ilan brings more than two decades of experience in global biotech and consumer health, and under his leadership BioHarvest has grown its flagship product VINIA into one of the fastest growing plant-based supplements in North America. He explains how the company uses plant cell biology and AI guided cultivation to deliver resveratrol, polyphenols, and other high value compounds with superior bioavailability, purity, and measurable clinical effects on arterial dilation, driven by increasing nitric oxide and resulting in improving physical energy, mental alertness and reducing oxidative stress You will learn: • Why traditional extraction wastes most of the plant and creates inconsistent supplement quality • How Botanical Synthesis produces highly bioavailable polyphenols without insecticides, herbacides, fungicides, solvents, or worrying about heavy metal levels.• Why VINIA increases arterial dilation, improves blood flow, and supports healthy nitric oxide levels • How reducing ET1 strengthens vascular health in ways typical nitric oxide supplements cannot • Why better blood flow supports brain performance, mental alertness, and daily physical energy • What clinical studies show about resveratrol absorption, bioavailability, and 12 hour activity in the bloodstream • How piceid resveratrol crosses the blood brain barrier to support cognitive function • Why BioHarvest is developing olive cell compounds like verbascoside for liver fat reduction and cognitive aging • How future saffron cell technology may influence mood, stress, and cognitive health • Why this approach offers major advantages for longevity, anti-aging strategies, and high-performance biologyDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: plant cell biology, Botanical Synthesis, Vinia polyphenols, piceid resveratrol, nitric oxide production, ET1 reduction, arterial dilation, vascular flexibility, blood flow optimization, brain oxygenation, cognitive alertness, oxidative stress reduction, bioavailable polyphenols, grape cell technology, olive cell compounds, verbascoside research, saffron cell cultivation, clinical blood flow studies, endothelial function, longevity supplementation **Visti www.vinia.com/Dave - for a generous discount on your next purchase** Resources: • VINIA Website: www.vinia.com/Dave • BioHarvest Website: https://bioharvest.com/• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:30 - How BioHarvest Works 5:23 - Piceid Resveratrol & Clinical Studies 13:37 - Blood Flow & Cardiovascular Benefits 17:08 - Brain Health & Cognitive Effects 20:07 - VINIA Product Line & Pricing 22:33 - Nitric Oxide Mechanism & ET1 26:39 - Chews & Hydration Mix 36:35 - VINIA Heroes Program 41:19 - Olive Cell Technology & Verbascoside 45:13 - Pharmaceutical Implications 51:30 - Saffron Development See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  --------  

  1:01:16

  --------

  1:01:16
• The Machine That Flicks on Your Brain in 30 Seconds | Biohacker Tools : 1373

  This episode shows you how light, vibration, and frequency-based technology can shift your brain state in minutes, unlock deep neuroplasticity, release stored trauma, and create coherence that normally takes years of meditation or psychedelic training. You will learn how these tools support performance, resilience, mitochondria, emotional regulation, and advanced biohacking. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with master healer Raffaele Gianfrancesco, whose work draws on energy medicine, Egyptian color healing, vibroacoustics, and light based entrainment. Raffaele trained in the Barbara Brennan lineage and spent years developing methods that shut down the default mode network, activate the thalamocortical circuit, and move people into deep meditative and altered states within minutes. His technology has attracted the attention of consciousness researchers, advanced meditation schools, ketamine clinics, and U. S. Air Force programs studying human resilience and pilot performance. Dave and Raffaele break down how vibroacoustic sound, harmonics, cymatics, and flickering light therapy guide the brain into gamma, delta, epsilon, and high resonance states that support clarity, emotional release, and rapid state change. Raffaele explains how vibration affects fascia and trauma storage, how light influences the cerebrospinal fluid and pineal gland, and why coherence is the key to shifting consciousness. They discuss ketamine assisted therapy, remote viewing, the Monroe Institute, the relationship between frequencies and brain states, the history of flickering light therapy, and how certain frequencies help loosen trauma patterns stored in the body. You’ll Learn: • How vibroacoustic sound and coherent light shut down the default mode network • Why fascia, trauma memory, and cerebrospinal fluid respond to vibration • How flicker based entrainment maps to gamma, delta, and theta brain states • Why the Air Force studies these tools for resilience and reaction speed • How ketamine combines with vibration and light to improve neuroplasticity • Why coherence, awe, and safety cues are essential for deep emotional release • What cymatics, harmonics, and frequency patterns reveal about consciousness Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: vibroacoustic therapy, flickering light therapy, consciousness technology, brainwave entrainment, cymatics healing, trauma release tools, ketamine neuroplasticity, default mode network reset, cerebrospinal fluid flow, energy medicine, Barbara Brennan healing, harmonic frequencies, gamma brain states, theta induction, somatic healing, astral plane experiences, remote viewing training, Monroe Institute methods, coherence training, vibration based meditation **https://roxiva.com/dave - for $1,000 off when you purchase the light and vibroacoustic bed together. ** Resources: • RoXiva Website: https://roxiva.com/dave • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 - Introduction • 1:14 - Vibroacoustic Technology • 4:08 - Energy Medicine and Healing • 10:06 - Coherence and Harmonics • 13:47 - Flickering Light Therapy • 16:10 - Stanislav Grof and LSD • 18:49 - Soul Sickness and Consciousness • 21:53 - Ayahuasca and Astral Plane • 28:36 - Psychedelics and Ego Death • 31:23 - Ketamine and Neuroplasticity • 37:31 - Trauma and Presence • 41:08 - Harmonics and Brain Frequencies • 44:04 - Flicker Fusion and Safety • 46:43 - Remote Viewing and Monroe Institute • 48:23 - Cerebrospinal Fluid and Consciousness • 50:32 - Product Details and Pricing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  --------  

  55:57

  --------

  55:57
• How I Lost 100 Pounds By Drinking Butter Coffee : 1371

  In 1999, a Silicon Valley millionaire on the brink of collapse took one mysterious sip atop a frozen Tibetan mountain - and everything changed. That moment sparked a global movement, rewrote the rules of fat and energy, and turned an ancient secret into a modern revolution.00:00 – The Dying Millionaire00:40 – The Mountain That Changed Everything01:30 – The Birth of Bulletproof Coffee02:40 – When the World Took Notice03:45 – The Fat Lie We All Believed04:45 – The Truth About Good Fats06:00 – Escaping the Sugar Trap07:15 – Stop Counting Calories09:00 – Why Inflammation Keeps You Fat10:40 – Eat Less Often, Not Less Food12:00 – The Exercise Myth13:40 – The Hidden Toxins Problem15:20 – Fixing the Root Cause17:40 – The Power of Mitochondria20:00 – One Sip That Changed EverythingThank you to our sponsors! -KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off.-EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  --------  

  22:36

  --------

  22:36

More Education podcasts

Trending Education podcasts

About The Human Upgrade: Biohacking for Longevity & Performance