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The Human Upgrade with Dave Asprey

Podcast The Human Upgrade with Dave Asprey
Dave Asprey
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletp...
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  • What You DON'T Know About Women’s Health! From Microbiome to Major Impact with Priyanka Jain : 1227
    Is this the missing link in fertility? The vaginal microbiome could be the most overlooked factor in optimizing women’s health, from fertility and hormonal balance to preventing infections and improving quality of life. In this groundbreaking episode, Dave Asprey talks to Priyanka Jain, co-founder and CEO of Evvy, about how understanding and improving the vaginal microbiome can transform women’s health outcomes. Priyanka shares how Evvy is advancing women’s health through cutting-edge genomic research and AI-powered insights, offering solutions to challenges like bacterial vaginosis, yeast infections, recurrent UTIs, and even infertility. You’ll learn why this critical microbiome plays such a vital role, how hormonal changes and lifestyle impact it, and how personalized approaches can improve reproductive and overall health. This episode explores not just women’s health but also how understanding the vaginal microbiome can influence relationships, biohacking, and even groundbreaking fertility research. Don’t miss this deep dive into the science and solutions shaping the future of health. Here’s what you’ll learn in this episode:  • The critical role the vaginal microbiome plays in women’s health and fertility  • How hormonal changes affect vaginal health and microbiome balance  • The link between vaginal microbiome imbalances and conditions like bacterial vaginosis, yeast infections, and UTIs  • Evvy’s innovative approach to using AI and genomics for personalized health insights  • Practical tips for maintaining microbiome health, including probiotics, hydration, and hormone balance  • The connection between the vaginal microbiome and overall quality of life Resources:  • 2025 Biohacking Conference – https://biohackingconference.com/2025  • Shop at Evvy (Use coupon code DAVE for $10 off!) – https://shareasale.com/r.cfm?b=1862577&u=2810239&m=116251&urllink=&afftrack= (Use coupon code DAVE for $10 off!)  • Follow Evvy on Instagram – https://www.instagram.com/evvy  • Danger Coffee – https://dangercoffee.com  • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/  • Dave Asprey’s Website – https://daveasprey.com  • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books  • Dave Asprey’s Linktree – https://linktr.ee/daveasprey  • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com  • Own an Upgrade Labs – https://ownanupgradelabs.com  • Upgrade Labs – https://upgradelabs.com  • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Sponsors: - Calroy | Head to https://calroy.com/dave for an exclusive discount. Timestamps:  • 00:00 Trailer  • 00:35 Introduction to Vaginal Microbiome  • 01:12 Meet Priyanka Jain of Evvy  • 02:03 Understanding the Vaginal Microbiome  • 04:37 Challenges in Women’s Health  • 09:55 Impact of Lifestyle on Vaginal Health  • 11:22 The Role of Diet and Supplements  • 15:24 Sexual Health and Vaginal Microbiome  • 27:25 Menopause and Vaginal Health  • 31:23 Optimizing Vaginal Health  • 39:31 Exploring Women’s Health Data  • 41:17 The Role of Vaginal Microbiome in Fertility  • 43:44 Affordable Testing and Discount Offers  • 45:31 The Impact of Lubricants on Vaginal Health  • 46:20 Innovative Ideas for Probiotic Products  • 47:29 Audience Questions and Precision Medicine  • 48:04 The Importance of Data in Women’s Health  • 54:31 Marketing and Misinformation in Vaginal Health  • 01:06:34 The Connection Between Diet and Vaginal Health  • 01:12:49 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • The World’s BEST Alcohol Alternative. Pleasure, Relaxation, and Clarity with TRU KAVA : 1226
    Is alcohol losing its grip as the go-to social drink? Enter kava—a centuries-old Polynesian plant that’s gaining global recognition for its ability to relax the mind, elevate mood, and enhance social connection without the toxic effects of alcohol. Kava, particularly in the form of TRU KAVA, is a psychoactive yet non-intoxicating drink that offers the perfect balance of calm focus and mental clarity. In this episode, Dave Asprey welcomes Cameron George, founder of TRU KAVA, to discuss why kava is becoming the drink of choice for those seeking a healthier, more connected lifestyle. Learn how kava impacts neurotransmitters like GABA and dopamine, enhances creativity and emotional grounding, and even helps the body recover from stress and trauma. Discover why kava is taking center stage in the biohacking and sober-curious movements as a new tool for wellness and connection. Here’s what you’ll learn in this episode: • Why 41% of Americans and 61% of Gen Z are drinking less alcohol • What kava is, how it works, and its history as a ceremonial and social beverage • The science behind kava’s calming and neuroprotective effects • How kava supports creativity, emotional resilience, and authentic social connection • Practical uses for kava, including stress relief, sleep enhancement, and travel recovery Resources: • 2025 Biohacking Conference – https://biohackingconference.com/2025 • TRU KAVA – https://www.trukava.com • TRU KAVA Instagram – https://www.instagram.com/trukava • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Sponsors: -Quantum Upgrade |Go to https://quantumupgrade.io/Dave for a free trial. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps: • 00:00 Intro • 00:37 Introduction to Alcohol Trends • 01:57 Meet Cameron George and TRU KAVA • 02:29 What is Kava? • 05:03 Kava’s Effects on the Brain • 06:53 Kava vs. Alcohol • 08:54 Active Compounds in Kava • 10:10 Kava’s Safety and Standardization • 16:17 Kava in Social Settings • 21:28 Kava and Psychedelics • 31:26 Kava for Public Speaking and Anxiety • 34:04 Kava in the Workplace: Enhancing Team Creativity • 35:22 Kava and Libido: The Unexpected Benefits • 36:06 Biohacking with Kava: Energy Allocation and Community • 39:00 Kava’s Role in Meditation and Emotional Awareness • 42:04 Kava During Pregnancy: Safety and Traditions • 44:37 Kava’s Neuroprotective Properties: A Deep Dive • 45:49 Kava and EMF Sensitivity: A Surprising Connection • 48:39 Kava for Frequent Travelers: Enhancing Mitochondrial Health • 52:46 Kava and Metabolic Health: Fasting and Fat Burning • 57:14 Kava Products: Oils, Beverages, and Their Uses • 01:01:27 The Future of Kava: Social Impact and Cultural Integration • 01:05:28 Conclusion: The Potential of Kava in Modern Society See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Urolithin A’s Secret to YOUTHFUL ENERGY and the Fight Against Inflammaging : 1225
    Have we finally discovered the key to youthful energy, longevity, and cellular health? In this episode, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer at Timeline Nutrition and a leading expert on mitochondrial health, cellular regeneration, and anti-aging science. With over 20 years of research, 50 clinical trials, and 15 patents under his belt, Dr. Singh unpacks the groundbreaking science behind Urolithin A, a revolutionary postbiotic that boosts mitochondrial function, enhances immune system resilience, and combats chronic inflammation. This episode goes beyond cutting-edge science. Dr. Singh reveals practical, real-world strategies to combat “inflammaging”—the chronic, low-grade inflammation that accelerates aging. Learn how fasting, gut health, and mitochondrial boosters like Urolithin A can rejuvenate your cells, fight fatigue, and supercharge your energy, vitality, and longevity. Here’s what you’ll learn in this episode: • What Urolithin A is and its role in mitochondrial health and cellular energy production • How to reverse “inflammaging” and reduce inflammation through nutrition, fasting, and biohacking • The connection between mitochondrial dysfunction and immune system aging • Real-life benefits of Urolithin A for energy levels, athletic recovery, skin health, and longevity • Why mitochondrial support is critical for combating aging and improving overall performance Resources: • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Timeline Nutrition - https://www.timeline.com/dave to get 10% off your first order • Timeline Instagram – https://www.instagram.com/timeline_longevity/ • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps: • 00:00 Introduction to Longevity and Mitochondria • 01:28 The Role of Mitochondria in Immune Health • 03:36 Understanding Inflammaging and Immune Aging • 07:47 Measuring Immune Health and Inflammation • 13:33 Urolithin A: A Mitochondrial Booster • 16:46 Dosage and Effects of Urolithin A • 26:11 Urolithin A and Exercise Performance • 28:31 Urolithin A for Skin Health • 31:34 Collagen and Aging: The Role of MMPs • 33:27 Personal Experience with MMPs and Recovery • 35:04 Measuring MMPs and Their Impact on Longevity • 36:18 Skin Health and Urolithin A • 38:39 Exploring Urolithin A’s Broader Benefits • 40:33 Brain Health and Urolithin A • 43:33 Combining Supplements for Optimal Health • 45:54 Omega-3s and Mitochondrial Health • 46:51 Ketones, MCTs, and Urolithin A • 54:30 Final Thoughts on MitoPure and Supplementation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Exosomes vs Stem Cells and LIFE-CHANGING Advice with Harvard Physician Dr. Edward Park : 1224
    Are exosomes the planet’s ultimate healing tool?! In this episode, Dave Asprey sits down with Harvard-trained physician Dr. Edward Park to explore the groundbreaking science of exosomes. Dr. Park, a pioneer in regenerative medicine and author of Exosomes: Songs of Healing, explains how these tiny cellular messengers are revolutionizing health and longevity by bypassing the limitations of stem cells. BUT this episode isn’t just about cutting-edge science. Dr. Park also shares profound insights into life, resilience, and emotional well-being, offering advice that goes far beyond medicine. From the power of forgiveness to breaking free of limiting beliefs, his perspective blends science, spirituality, and practical wisdom for living a better life. Here’s what you’ll learn in this episode: • How exosomes work and why they’re being called the future of regenerative medicine • The key differences between exosomes and stem cells—and which is better for healing • Real-life applications of exosome therapy for injuries, anti-aging, and overall health • The potential of exosomes to enhance brain function, reduce inflammation, and promote recovery • Dr. Park’s advice on emotional resilience, gratitude, and creating lasting change With over a decade of experience, Dr. Park shares compelling case studies, cutting-edge insights, and practical advice for anyone looking to upgrade their body, mind, and life. Whether you’re managing chronic pain, exploring anti-aging therapies, or seeking wisdom for navigating life’s challenges, this episode has something for everyone. Sponsors TRU KAVA | Go to https://trukava.com and enter code DAVE15 at checkout for 15% off Resources: • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Dr. Edward Park’s Website: Recharge Biomedical – https://www.rechargebiomedical.com • Dr. Edward Park’s Book: Exosomes: Songs of Healing – https://www.amazon.com/EXOSOMES-Songs-Healing-Ed-Park/dp/098260632X • Dr. Edward Park’s YouTube Channel – https://www.youtube.com/channel/UCpp9DlRArB1rKAWNwoouiTg • Dr. Edward Park on Instagram – https://www.instagram.com/dredpark/ • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps: • 00:00 Introduction to Exosomes and Healing • 00:48 Understanding Exosomes: Stem Cell Communication • 01:19 Dr. Edward Park’s Insights on Exosomes • 02:47 Exosomes vs. Traditional Treatments • 04:44 Exosomes in Regenerative Medicine • 07:33 Cost-Effective Regeneration Protocols • 12:35 Exosomes for Hair Growth • 14:37 Stem Cells and Brain Health • 25:33 Banking Stem Cells for Future Use • 35:27 Epigenetic Age and Longevity Predictors • 37:48 CRISPR and Gene Editing: Risks and Benefits • 39:43 Basic Health Tips for Longevity • 41:02 Spirituality, Past Lives, and Healing • 42:50 Questioning Medical and Political Narratives • 47:54 The Importance of Free Speech • 01:07:40 The Role of Intuition in Medicine • 01:09:22 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Is Infrared Light the KEY to Longevity? Detox, Recovery, and Increased Energy with Sunlighten Saunas : 1223
    Is biohacking your sweat the secret to vitality? Dave Asprey dives into the transformative world of infrared saunas with Connie Zack, founder of Sunlighten and a 25-year innovator in the space. Together, they uncover how targeted light and heat therapy can unlock unparalleled health benefits, from detoxing heavy metals to energizing your body at the cellular level. Here’s what you’ll learn in this episode: • Why infrared saunas excel at detoxing heavy metals and toxins • How they mimic exercise to boost cardiovascular health and recovery • The science behind infrared’s impact on mitochondrial energy and longevity • Surprising benefits for gut health, inflammation, and hormone balance • Hacks to get the most out of your infrared sauna sessions Connie shares cutting-edge research and personal insights, offering practical ways to integrate infrared therapy into your routine. Whether you’re looking to recover faster, improve your mood, or support long-term health, this episode delivers the tools you need to take your biohacking game to the next level. Special Offer: Use code “DAVE” at sunlighten.com to get up to $1,000 off until December 6th! Sponsors:-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Sunlighten Saunas Website – https://www.sunlighten.com/dave/?utm_source=DaveAsprey&utm_medium=Partner&utm_content=Podcast&leadsource=DaveAsprey&utm_campaign=DaveAsprey • Sunlighten Saunas on Instagram – https://www.instagram.com/sunlightensaunas/ • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps • 00:00 Introduction to Infrared Saunas • 00:27 Meet Connie Zack: Leading Voice in Infrared Saunas • 00:50 The Science Behind Infrared Saunas • 02:35 Infrared Saunas vs. Traditional Saunas • 05:41 Health Benefits of Infrared Saunas • 08:14 Technological Advancements in Infrared Saunas • 17:36 The Role of LEDs in Infrared Saunas • 22:37 Practical Tips and Personal Experiences • 28:14 Detoxing and Energizing with Glutathione • 28:40 Pre and Post-Sauna Rituals • 29:05 Habit Stacking in the Sauna • 29:41 Managing Overheating Devices • 31:05 Creative Breakthroughs in the Sauna • 32:14 Scientific Method and Personal Experience • 36:05 Understanding Glucose Spikes • 38:44 Longevity Benefits of Infrared Saunas • 43:27 Infrared Saunas and Skin Health • 45:29 Extreme Detox Protocols • 48:28 Grip Strength and Longevity • 50:34 Customizing Your Sauna Experience See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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