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Infinite Loops

Jim O'Shaughnessy
Infinite Loops
Latest episode

325 episodes

  • Infinite Loops

    Jason Buck - Faith, Failure, and Finance (Ep. 316)

    28/05/2026 | 2h 1 mins.
    Jason Buck, founder and CIO of Mutiny Funds, joins Infinite Loops to tell the painful and darkly funny story of how the 2007–2008 crash destroyed his real estate business, wiped out his paper wealth, and taught him one of the hardest lessons in markets: being right is not the same thing as making money.
    Jason explains how he went from real estate developer to volatility trader and eventually built his philosophy around survival, resilience, and the "Cockroach Portfolio." He and Jim explore why true diversification always feels uncomfortable, why human behavior is the most persistent source of market mistakes, and why investing beliefs often resemble religion.

    Important Links:

    Learn more about Mutiny Fund here: https://mutinyfund.com/

    Listen to more from Jason here: https://mutinyfund.com/podcasts
  • Infinite Loops

    Chelsea Follett - Why Progress Is the Exception, Not the Rule (Ep. 315)

    21/05/2026 | 1h 29 mins.
    Chelsea Follett joins Infinite Loops to explain why the "good old days" were far darker than most people imagine — and why progress should never be taken for granted.
    Chelsea is the managing editor of Human Progress and author of Centers of Progress and the forthcoming The Grim Old Days. We discuss why humans are so drawn to nostalgia, what life was really like in the preindustrial past, why doomsday predictions keep failing, and how freedom, innovation, and open inquiry helped create the modern world.

    Important Links:
    Learn More about Chelsea's upcoming book here: https://www.simonandschuster.com/books/The-Grim-Old-Days
    Read more of Chelsea's Human Progress work here: https://humanprogress.org/authors/chelsea-follett
  • Infinite Loops

    Mykhailo Marynenko - AI Tools That Give Creators More Control (Ep. 314)

    15/05/2026 | 1h 43 mins.
    Mykhailo Marynenko joins Infinite Loops for for a fascinating conversation about the future of AI, creative tools, privacy, and data ownership. 
    From growing up in his father's phone repair shop in Ukraine to building experimental AI systems today, Mykhailo has spent his life taking things apart, figuring out how they work, and rebuilding them in unexpected ways. 
    We explore how AI can help creators without replacing them, why privacy and data ownership matter, and what it means to design tools that give people more control over complex information.

    Important Links

    More about Misha: https://linktr.ee/0x77dev?utm_medium=mykhailo.link
  • Infinite Loops

    Danielle Crittenden - Dispatches from Grief (Ep. 313)

    07/05/2026 | 1h 52 mins.
    On a February morning, Danielle Crittenden's world cleaved in two: the life before her daughter Miranda was found dead in her Brooklyn apartment, and the life after.

    Two years and three months later, Danielle joins Infinite Loops to discuss her luminous memoir, Dispatches from Grief, which unflinchingly traces the strange afterlife of grief with precision, restraint, and unexpected humor.

    This conversation explores what grief really feels like. With extraordinary honesty and grace, Danielle shares the physical pain, the loneliness of loss, and the slow work of carrying her daughter's memory forward. 

    Dispatches from Grief is out now: Infinite Books | Amazon

    Danielle's Substack: The Femsplainers With Danielle Crittenden
  • Infinite Loops

    Saloni Dattani - The Hidden Bottleneck Holding Back the Future of Medicine (Ep. 312)

    30/04/2026 | 1h 25 mins.
    Saloni Dattani, author of the Scientific Discovery Substack and founding editor of Works in Progress magazine, joins Infinite Loops to discuss why medical innovation is often much slower than it needs to be.

    We explore why so much research still begins in animal models, how poor data distorts our understanding of disease, why clinical trials are one of the biggest bottlenecks in medicine, and how better systems could help promising treatments reach patients faster.

    Important Links:

    Read more from Saloni here: https://worksinprogress.co/our-authors/saloni-dattani

    And here: https://substack.com/@salonium

    And listen to Saloni's podcast "Hard Drugs" here: https://harddrugs.worksinprogress.co/
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About Infinite Loops
Every Thursday, join Jim O'Shaughnessy and his favorite people as they arm you with the tools & fresh perspectives required to upgrade your HumanOS and thrive in our messy, probabilistic world. Visit our Substack at newsletter.osv.llc for full transcripts, highlights, weekly doses of timeless wisdom, and a bounty of other goodies designed to make you go, "Hmm that's interesting!"
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