Surgical mitral valve repair with Dan Brockman and Matteo Rossanese
A chance to cut is a chance to cure?
In this episode we cover:
The principles of cardiopulmonary bypass
Anticoagulation
The mitral valve repair itself
The ideal surgical candidate for mitral valve repair
The outcomes of such a procedure
The original study is below and covers further specifics such as case selection and post-op care plus summaries and discussion of fatalities. An overarching aim was that this should be useful for other centers establishing such a program.
Improvements over time are summarised by improving survival rates: 22/33 in the first quartile, 27/33 in the second quartile, 28/33 in the third quartile, and 30/33 in the final, most recent group. Do have a read.
Improvement in short-term outcome over time, in a single center embarking on a canine mitral valve repair program using a structured multidisciplinary approach
https://onlinelibrary.wiley.com/doi/10.1111/vsu.14229
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Lily exposure in cats with Dr Erica Reineke
In this podcast we discuss the actual prevalence of AKI in cats exposed to lilies, how bad the AKI seems to get when it does occur, and the changing management practices over time in toxin exposures, let alone in the management of lily exposure itself.
Happy listening!
Prevalence of acute kidney injury and outcome in cats treated as inpatients versus outpatients following lily exposure
https://avmajournals.avma.org/view/journals/javma/263/1/javma.24.05.0355.xml
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Burning questions on coagulation, thromboprophylaxis and hyperfibrinolysis with Rob Goggs and Alex Lynch - Part 2
Alex Lynch and Rob Goggs discuss the uses of viscoelastic testing, hyperfibrinolysis, when to use antifibrinolytics in dogs, and when to stop them! This is part 2 of 2.
A selection of studies referred to:
CURATIVE guidelines https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.12801
Characterisation of changes in the haemostasis system in dogs with thrombosis https://onlinelibrary.wiley.com/doi/10.1111/jsap.12037
CRASH 2 Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60835-5/fulltext
CRASH 3 Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext
WOMAN trial Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30638-4/fulltext
Rapid resolution of hyperfibrinolysis in dogs with spontaneous hemoperitoneum following surgical control of hemorrhage https://onlinelibrary.wiley.com/doi/full/10.1111/vec.13300
FAT CAT https://www.sciencedirect.com/science/article/pii/S1760273415000958
SUPERCAT https://avmajournals.avma.org/view/journals/javma/263/4/javma.24.09.0584.xml
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Burning questions on coagulation, thromboprophylaxis and hyperfibrinolysis with Alex Lynch and Rob Goggs - Part 1
Alex Lynch and Rob Goggs answer questions on indications for thromboprophylaxis, knowledge gaps in the area, if or when we should be more pro-active and ATE in cats. This is part 1 of 2.
A selection of studies referred to:
CURATIVE guidelines
https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.12801
FAT CAT
https://www.sciencedirect.com/science/article/pii/S1760273415000958
SUPERCAT
https://avmajournals.avma.org/view/journals/javma/263/4/javma.24.09.0584.xml
Characterisation of changes in the haemostasis system in dogs with thrombosis
https://onlinelibrary.wiley.com/doi/10.1111/jsap.12037
CRASH 2
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60835-5/fulltext
CRASH 3
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext
WOMAN trial
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30638-4/fulltext
Rapid resolution of hyperfibrinolysis in dogs with spontaneous hemoperitoneum following surgical control of hemorrhage
https://onlinelibrary.wiley.com/doi/full/10.1111/vec.13300
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Rivaroxaban and apixaban with Alex Lynch and Rob Goggs
Do you use rivaroxaban? Do you want to know more about using rivaroxaban? Or even apixaban? In this podcast we discuss both anticoagulant drugs with study authors Alex Lynch and Rob Goggs. I learnt plenty and I hope you will too!
We also recorded a ‘burning questions on thromboprophylaxis’ podcast that will be out very soon, so keep an eye out for that too! You can also find the podcasts on the www.vetlit.org/podcast page itself.
In this episode we cover:
The background to the use of oral anticoagulants
A brief tour of pharmacokinetics and pharmacodynamics.
The biological effect of both drugs, when it happens and the concept of rebound hypercoagulability after drug withdrawal.
The original study is here:
Comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban in dogs
https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.17216
Keeping you up to date with veterinary literature. This journal club podcast is focused on small animal topics, covering important, recent literature and presenting it in a digestible format. It is brought to you by VetLit.org and the team: Simon Cook, Chris Scudder, Abbe Crawford, Matteo Rossanese and Kieran Borgeat.
New Zealand