First Principles with Christian Keil

Matt Loszak is building a nuclear reactor factory for a new kind of reactor: one that is almost impossible to melt down.

1X Technologies is building the world's safest autonomous, humanoid robots.

And they want to start selling robots into consumer homes next year. 

How do you make a robot safe for humans? The answer is complicated — so I went to 1X HQ in Sunnyvale, CA to find out.

Engines are loud — Whisper Aero is changing that.

Season 2, Episode 1: JC Btaiche, Fuse Energy
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Links:
ElectroBOOM: https://www.youtube.com/watch?v=_PcBgym21TA
Fuse's Paper in Nature: https://www.nature.com/articles/s41598-024-67774-4
Fuse — https://www.f.energy
People:
JC Btaiche — https://x.com/JCBtaiche10
Christian Keil — https://x.com/pronounced_kyle

Today’s episode is brought to you by Strata. Modernize your IAM with Identity Orchestration. Visit https://strata.io/firstprinciples to learn more!
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Episode 15: Bryan Johnson spends $2m/year to not die. But this is more than just a health craze — it’s the birth of a new, secular religious movement. Here’s what Bryan believes.

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(00:00) - Introduction
(01:13) - Zeroth Principles Thinking: Going Beyond First Principles
(04:05) - The Journey to "Don't Die": Bryan's Thought Experiments and Realizations
(07:28) - Is "Don't Die" a Religion? Examining the Parallels
(10:40) - Bryan's Roles in "Don't Die": Philosopher, Embodiment, Message Bearer
(13:05) - Sponsor Break
(14:08) - Quantifying Death: Introducing "Die Scores" for Behaviors and Choices
(17:03) - What is Death and What is Aging? A First Principles Perspective
(19:40) - Measuring Biological Age: Organ by Organ Analysis of Bryan's Body
(23:48) - The Penis as a Marker of Overall Health and Vitality
(26:33) - Epigenetic Clocks and the Pace of Aging Calculated Tests
(30:18) - Bryan's Experience with Follistatin Gene Therapy
(32:25) - Kernel: Building a Mass Market Brain Interface with Time-Domain FNIRS
(36:48) - The Power Law Interventions: Identifying the Most Effective Longevity Levers
(39:22) - Assembling a Team of Scientific Misfits to Tackle Aging
(41:05) - Dreaming Up Ideas: Bryan's Nocturnal Creativity
(42:15) - Telomeres and the Risks of Telomerase Gene Therapy
(44:38) - Reflections on the Challenges of Commercializing Deep Tech
(46:29) - Conclusion: Banding Together to Build an Amazing Future

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Links:
Christian Keil – https://twitter.com/pronounced_kyle
Bryan Johnson - https://x.com/bryan_johnson
Bryan Johnson Personal Website - https://www.bryanjohnson.com/
Blueprint - https://blueprint.bryanjohnson.com/

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Production and marketing by The Deep View (https://thedeepview.co). For inquiries about sponsoring the podcast, email team@firstprinciples.fm

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