The Dr. Gabrielle Lyon Show

Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comAre your immune cells aging faster than you are? In this episode, Dr. Gabrielle Lyon sits down with Dr. Anurag Singh, a leading physician-researcher and Chief Medical Officer at Timeline, to discuss a groundbreaking discovery: the gut-muscle-immune axis. While we often focus on muscle mass for longevity, new research published in Nature Aging reveals that our immune system undergoes a similar decline, with youthful sentinel cells (naive CD8 T-cells) dropping by 75% as we reach age 50. Dr. Singh explains how mitophagy —the targeted recycling of damaged mitochondria—is the key to "rewiring" an aging immune system to fight infection 20% more effectively. In this episode: Alzheimer’s of the Muscle: Why sporadic inclusion body myositis (sIBM) is often misdiagnosed as simple aging. The Power of Urolithin A: How this postbiotic compound induces mitophagy to increase mitochondrial abundance by 20% in just 28 days. Immune Imprinting: Why children get 6-8 colds a year while adults only average 2-4. Repurposing Longevity Drugs: Dr. Singh’s take on Metformin, Rapamycin, and GLP-1s for life extension. The 1:1 Exercise Rule:Why 150 minutes of moderate activity is the threshold for mitochondrial biogenesis. Thank you to our sponsors: BodyHealth - Use the code LYON 20 to get 20% off your first order https://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/ Timeline - Get 35% off a Mitopure subscription at https://www.timeline.com/drlyon Manukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts. Chapters: 0:00 - Can You Tell If Your Immune System Is Healthy? 1:37 - Alzheimer’s of the Muscle: Muscle-Immune Dysfunction 5:59 - The Thymus Design Flaw: Why Our Immune "Ammo" Disappears 8:44 - Naive CD8 T-Cells: The Elite Forces of Immunity 12:24 - The Axis of Aging: Mitochondria and Immune Cells in Muscle 16:15 - Mitophagy vs. Autophagy: Targeted Cellular Recycling 19:11 - Study Review: Rewiring the Immune System with Urolithin A 24:13 - Mitochondrial Remodeling: Switching from Glucose to Fatty Acids 27:45 - The Trifecta: Gut-Muscle-Immune Axis Connection 31:13 - Parkinson’s and the PINK1/Parkin Mitophagy Pathway 35:04 - Clinical Results: Improving Leg Strength in 4 Months 38:51 - Joint Health: Can We Remodel Cartilage with Mitophagy? 43:34 - Targeted Mitophagy Inducers: Exercise vs. Postbiotics 46:44 - Precision Nutrition: The Ideal Muscle Longevity Supplement 53:33 - Why Alzheimer’s is Now Considered an Inflammatory Disease 1:00:13 - The Placebo Effect: You Cannot Deceive the Immune System 1:03:13 - Lymphocyte Counts: The Clinical Marker for Immune Aging 1:08:14 - Rapamycin and Metformin: The Future of Longevity Drugs 1:11:42 - Optimal Dosing: Why 1,000mg of Urolithin A is the Standard 1:15:13 - Sports Medicine: Reducing Muscle Damage Markers (Creatine Kinase) 1:20:03 - The Final Frontier: Brain Aging and Selenium Repair Connect with Dr. Anurag Singh Instagram: @timeline_longevity Website: https://www.timeline.comFind Dr. Gabrielle Lyon at: Instagram:@drgabriellelyon TikTok: @drgabriellelyon

Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comIf you are only focusing on building muscle, you are missing half the equation for long-term mobility. In this mashup episode, Dr. Gabrielle Lyon brings together top orthopedic experts to discuss the critical importance of joint and tendon health.While muscle develops relatively quickly, your tendons and ligaments can take 6 to 9 months to fully adapt to a new training stimulus. This gap is where most injuries happen. We dive deep into the biological mechanics of tendons, the"athletic accommodation timeline," and why you must progressively overload your connective tissue—not just your muscle bellies.You will learn:The Menopause Connection: Why women face a 30% higher risk of arthritis and rapid bone loss after age 50, and the role of estrogen in joint inflammation.Osteoporosis Prevention: Why high-impact "flight" exercises (jumping) are more effective for bone density than traditional lifting alone.The Frozen Shoulder Mystery: How to identify the warning signs and why this condition is often linked to hormonal shifts rather than trauma.Injury Recovery & Prehab: The truth about PRP, needle tenotomy, and the "anti-fragility" mindset needed to build a resilient body.The History of Muscle: How ancient Greek views of "pneuma" and the "gift of strength" shaped our modern misunderstanding of movement.Stop training until you break. Learn how to track your progress, prioritize stability over raw mobility, and design a life built for anti-fragility.0:00 - The Gap Between Muscle and Tendon Adaptation1:32 - What Are Tendons? Visco-Elasticity and Force Dissipation4:36 - The Rotator Cuff: Stabilizing the "Golf Ball on a Tee" 6:40 - The Athletic Accommodation Timeline: Why 6-9 Months Matters8:36 - Progressive Overload for Connective Tissue, Not Just Muscle11:36 - GLP-1s and Bone Health: Does Ozempic Increase Fracture Risk?14:34 - Preventing Osteoporosis: The Power of Impact Training18:15 - Bisphosphonates vs. Mechanical Loading for Bone Quality21:10 - The Hidden History of Muscle: From Galen to Ancient Greece26:48 - The Myth of "Pneuma" and the Soul in the Muscle30:55 - Supercompensation: The "Gift from Zeus" in Performance36:35 - Defining Impact Exercise: Why "Flight" is Better for Bones39:48 - Building Your Base: Why Bone Health is Won Before Age 3042:38 - Oral Contraceptives and Peroperative Blood Clot Risks45:21 - The Hard Truth: How Nicotine Destroys Orthopedic Healing47:55 - Testosterone and Muscle Mass vs. Bone Density in Women51:41 - Relative Energy Deficiency in Sport (RED-s) and Stress Fractures55:53 - Long-Term Menopause Consequences: Mobility and Hip Fractures1:01:58 - Tendinopathy Treatments: Needle Tenotomy, 10X, and PRP1:07:26 - Full Thickness vs. Incomplete Tendon Tears1:12:05 - Prehab is Real: The Push-Up with a Plus and Skater...

Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comThank you to our sponsors: BodyHealth - Use the code LYON20 to get 20% off your first order https://bodyhealth.com/ Manukora - Visit MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts. BON CHARGE - Holiday Sale https://boncharge.com for 25% off Our Place - Visit fromourplace.com/DRLYON and use code DRLYON for 10% offFind Dr. Gabrielle Lyon at: Instagram:@drgabriellelyonTikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.pagePre-order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.Timestamps: 0:00 - FDA Lifts Blackbox Warning on HRT1:08 - Definitions: Viralization & Androgens3:08 - The New Landscape of Women's Health4:46 - Gold Standard Testing: Mass-Spec5:52 - Finding the Estrogen Sweet Spot for Men8:07 - Testosterone Lab Ranges for Women10:16 - Is Testosterone Safe for Women?13:30 - Anabolic vs. Androgenic Steroids16:56 - HRT Red Flags: Who Should Not Start18:19 - Longevity Benefits of HRT21:23 - Estrogen's Role in Brain Health24:32 - Performance Impact in Young Women33:03 - Type 2 Muscle...

If you or someone you know is experiencing suicidal thoughts, emotional distress, or a mental health crisis, call or text 988, or chat via 988lifeline.org. Support is available 24/7. You are not alone, and help is available.Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comDr. Gabrielle Lyon sits down with renowned medical correspondent and OB/GYN, Dr. Jen Ashton, for a profoundly personal and candid conversation about navigating life's most intense tragedies while maintaining a public career.Dr. Ashton bravely opens up about the devastating suicide of her first husband, a world-class surgeon, 18 days after their divorce was finalized. She shares the raw reality of being in clinical shock and how the immense tragedy became an unexpected catalyst for post-traumatic growth.Dr. Ashton, who holds a Master's degree in Nutritional Sciences, also brings her medical expertise to current health debates:The Power of Fitness: Learn how resistance training became Dr. Ashton's lifeline to snap her out of emotional numbness and shock.The Hormone Misinformation Crisis: They discuss the flawed data and flawed media that led to 20 years of women being under-treated for menopause after the Women's Health Initiative (WHI).GLP-1 Myths: Dr. Ashton breaks down the top myths surrounding GLP-1 medications, the difference between absolute vs. relative risk, and the non-weight related benefits that are just beginning to emerge.The Problem with Extremes: They address the societal tendency to seek out quick-fix solutions in health, menopause, and obesity care, arguing that the true sweet spot is in a nuanced, moderate position.Finding Love Again: Dr. Ashton shares the unexpected miracle of finding profound love with her current husband, legendary sports executive and TV producer, Tom Werner.About Jen Ashton: Retiring stiff paper gowns and unrelatable medical advice, Dr. Jennifer Ashton, a Board-certified Ob-Gyn, author, and TV medical correspondent, breaks the barrier between doctor and patient. Affectionately referred to as your all-in-one ‘BFF’/Ob-Gyn, Dr. Jennifer Ashton marries an unparalleled medical background with an accessible‘girl’s-girl’ attitude. Though Dr. Ashton can easily speak to the latest beauty and fashion trends, this Ivy League graduate means business when it comes to women’s health.Thank you to our sponsors: Timeline - Get 20% off your order at https://timeline.com/LYON OneSkin - Get 15% off with the code DRLYON – https://www.oneskin.coFind Jen Ashton at: Book: Life After Suicide - https://a.co/d/0HvOeSHIG:

Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comDr. Gabrielle Lyon sits down with fertility specialist Dr. Natalie Crawford to tackle the urgent rise in infertility across both men and women. Dr. Crawford, an advocate for proactive reproductive health, reveals why inflammation is hijacking your fertility and why the old dogma that "age is the only factor" for egg quality is dangerously incomplete.They cover critical, actionable steps—from the most important lifestyle changes you can make before IVF, to the toxic habits that are directly lowering sperm counts and causing miscarriages. Learn the three essential fertility awareness methods (FAMs) and what your doctor is missing when they check your thyroid.Who is Natalie Crawford:Natalie Crawford is a double board-certified fertility doctor with a nutrition background, here to help you understand your body and hormones, optimize your lifestyle, and take control of your reproductive future with confidence.Thank you to our sponsors: Timeline - Get 20% off your order at https://timeline.com/LYON BON CHARGE Holiday Sale https://boncharge.com for 25% off Don’t miss NOBL’s biggest Sale of the Year! Head to NOBLTravel.com for up to 58% off your entire order! Find Natalie Crawford at: Web: https://www.nataliecrawfordmd.com/https://www.youtube.com/c/NatalieCrawfordMD/videosPODCASThttps://www.nataliecrawfordmd.com/blog-1Find Dr. Gabrielle Lyon at: Instagram:@drgabriellelyon TikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.pagePre-order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623 Disclaimers: This episode includes paid sponsorships. The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services,...