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Live Long and Well with Dr. Bobby

Dr. Bobby Dubois
Live Long and Well with Dr. Bobby
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  • #54 What are we to believe? (With Dr. Adam Cifu)
    Send us a textSummary: I unpack why medicine sometimes reverses course—and how you can tell sound evidence from shiny anecdotes—with physician-author Dr. Adam Cifu of the University of Chicago and co-author of Ending Medical Reversal.Key topics & takeawaysWhy medicine “flips”: Plausible theories + observational data → premature guidelines; true answers require randomized trials. Classic examples: menopausal hormone therapy, early peanut avoidance, and stents for stable angina (LEAP trial, COURAGEOpen-minded skepticism: Ask, “What’s the human outcomes evidence?” Cool mechanisms and moving testimonials aren’t proof.Hype outside the clinic: Mitochondria “rechargers,” microbiome panaceas, and biological age tests are intriguing—but not ready for prime time.Nutrition sanity:  For supplement evidence summaries, I like Examine.When AI helps (and when it doesn’t): Tools can orient you to established topics; they’re weaker on breaking studies. Look for linked primary sources.N-of-1 experiments: When evidence is uncertain and the outcome is measurable (sleep, blood pressure, pain), test on yourself—track a baseline, try the change, measure again, and, if possible, stop-start to confirm. Use symptom diaries, validated scales, or wearables.Humility is a signal: Trust sources that sometimes conclude “we don’t know.” I often check Cochrane Reviews for balanced syntheses.About my guest Adam Cifu, MD is a professor of medicine at the University of Chicago, author of 140+ peer-reviewed papers, and co-author of Ending Medical Reversal. He writes at Sensible Medicine.Call to action If this episode helped you think more clearly about health claims, share it with a friend and leave a quick review on Apple or Spotify. For my newsletter on practical, evidence-supported longevity, visit DrBobbyLiveLongAndWell.com.
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  • #53: Ultra-Processed Foods: How Harmful and Why?
    Send us a textI unpack what “ultra-processed” really means, why these foods are so easy to overeat, what the best evidence shows (including metabolic-ward studies), and how I personally navigate them without fear or perfectionism. Key topics & evidence (in plain English):What counts as “ultra-processed”? I walk through the NOVA system—useful, not perfect—and where borderline items (frozen meals, boxed mixes) fit. See an overview of NOVA classifications here. How we got here: post-WWII abundance of refined flour, cheap sugars, oils, and a cultural push for convenience—now ~60% of the U.S. diet comes from UPFs (study). Additives: stabilizers, emulsifiers, preservatives, and colors are generally recognized as safe (GRAS). I explain why, on their own, they’re probably not the main health issue. The bigger problem: UPFs are energy-dense, engineered for bliss (fat/sugar/salt + perfect texture), and easy to eat quickly—driving higher calorie intake.  • Metabolic-ward crossover trial: +~508 kcal/day when participants ate UPFs vs minimally processed (Cell 2019). • Overweight adults in a crossover design: +~814 kcal/day on the UPF week (PubMed). • Another recent crossover RCT reports ~300 kcal/day higher on UPFs (Nature Medicine 2025). What I recommend (and what I do):Prioritize whole foods most of the time; shop the perimeter; cook when you can. Canned tomatoes/beans and frozen fruits/peas are fine helpers. If weight, diabetes, or blood pressure are concerns, be extra cautious with UPFs—they’re designed to be irresistible and calorie-dense. Moderation wins: I enjoy favorites (yes, even boxed mac ’n’ cheese and crunchy peanut butter) without letting them dominate my plate. Takeaways you can use today:Build meals around minimally processed proteins, veggies, fruits, and beans; let convenience items support—not star—in your diet. Watch “calorie-dense + easy to overeat” combos (chips, sweets, fast food). If you have them, portion once, then put the package away. If symptoms or inflammation are puzzling you, try a short UPF-light experiment (2–4 weeks) and see how you feel. If this episode helped, please follow and leave a quick review—and share it with a friend who’s curious about UPFs. For my newsletter and resources, visit drbobbylivelongandwell.com.
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  • #52: We can reduce our cancer risk
    Send us a textCancer is the second leading cause of death, and while it sparks fear for good reason, 40% of cases are preventable. In this episode, I outline six practical, evidence-based steps that can help reduce your risk.We begin by understanding which cancers are most common based on gender—breast, colon, and lung in women; prostate, colon, and lung in men. While some rare cancers (like pancreatic or ovarian) evoke greater fear, the focus here is on the ones we’re more likely to face and can meaningfully act on.Next, I break down risk factors into two categories. Some are unavoidable—your sex, age, or family history. For example, if a close relative had breast or colon cancer, early screening or genetic testing may be warranted. However, only about 5–10% of cancers are directly linked to inherited genetic mutations (American Cancer Society).The more empowering list? Avoidable risk factors—where our actions matter most. Smoking remains the leading modifiable cause of cancer, responsible for about 19% of all cases. Excess weight and obesity account for another 8% and are especially tied to hard-to-treat cancers like pancreatic and ovarian (ScienceDirect) and PubMed). Visceral fat appears more predictive than BMI alone. Alcohol, especially in large quantities, is also linked to liver, GI, and breast cancers.Some risks are cancer-specific. HPV causes nearly all cervical cancers, and melanoma is largely driven by UV exposure. Air pollution, especially particulate matter, may slightly increase lung cancer risk (ASCO Global Oncology).Step three is to act on what you can. Quit smoking, aim for a healthy weight, wear sun protection, and ensure your kids get their routine HPV and Hepatitis B vaccines. Exercise plays a major role too—high activity levels correlate with 10–20% lower risk of several major cancers (JAMA). In colon cancer survivors, regular exercise reduced recurrence by 30% (PubMed).Step four is awareness: don’t ignore new symptoms like unexplained bleeding or lumps. Early detection can be life-saving.Step five is screening. If you're 45 or older, colonoscopy is now recommended. Women should get regular mammograms and PAP smears, and individuals with smoking history may benefit from lung CT scans. For rarer cancers with family history, targeted screenings may apply. I also address why whole-body MRIs and liquid biopsies aren’t ready for routine use.Step six? Don’t put your hope in supplements. Large trials show omega-3s, vitamin D, beta carotene, and vitamin C offer no real protective benefit (NEJM VITAL Study, Meta-analysis on Vitamin C, JNCI on aspirin).Takeaways: You can reduce your cancer risk by modifying lifestyle factors like smoking, weight, and activity. Don’t delay screenings—they catch cancers early when treatment is most effective. And remember: no supplement replaces proven preventive strategies.Visit drbobbylivelongandwell.com for more evidence-based tools, and listen to the full episode for actionable steps to help you live long and well.
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  • #51 Can Thinking Positively Cure Disease?
    Send us a textVisit my websiteCan a positive mindset truly improve your health—or even help you beat disease? In this episode, Dr. Bobby and guest Sean McDevitt explore the evidence behind optimism, visualization, and prayer to uncover what really works.In today’s episode of Live Long and Well, Dr. Bobby is joined by fitness and life coach Sean McDevitt to explore whether positive thinking can influence health outcomes. They dive into both anecdotal and clinical evidence, starting with sports psychology and then navigating the science behind mindset and disease. The conversation opens with laughter and smiles—literally. Inspired by Norman Cousins’ Anatomy of an Illness, Dr. Bobby references a meta-analysis showing genuine smiling does, in fact, temporarily boost happiness, while artificial smiling (like holding a pen in your mouth) doesn’t.They begin with sports, where 86 studies show that visualizing athletic success can improve performance in agility, strength, and game-specific skills. Next, they ask a deeper question: does having a positive attitude affect the progression of serious disease? A meta-analysis of 26 studies on life satisfaction and longevity suggests happy people may live longer—especially when it comes to heart health. Optimism, for instance, was linked to a 35% reduction in cardiovascular events and a 15% decrease in all-cause mortality.However, when it comes to cancer, the picture gets murkier. A review of 165 studies links stress to poorer survival, but a separate meta-analysis on coping styles found no consistent impact on recurrence or survival. One influential study on breast cancer patients even found that while helplessness predicted worse outcomes, having a “fighting spirit” made no significant difference (source). As Dr. Bobby notes, it’s important not to burden patients with guilt if they can’t “stay positive.”The critical question becomes: if you're not naturally optimistic, can you cultivate positivity—and will it help? Encouragingly, several intervention studies suggest it might. One trial showed cardiac markers improved after optimism training, and a meta-analysis of 56 RCTs found a 15% boost in immune function after psychological interventions. A small MS study linked mindfulness to better walking ability, and a large RCT on breast cancer showed a 45% drop in recurrence with stress-reduction and mood-enhancing strategies.Finally, the episode touches on spirituality. While many find comfort in prayer, evidence from an RCT of 800 ICU patients and a [meta-analysis] shows no significant impac
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  • #50 Navigating Serious Illness: Eight Crucial Lessons
    Send us a textVisit drbobbylivelongandwell.com In this deeply personal episode, Dr. Bobby reflects on his wife's cancer diagnosis and shares eight powerful lessons for anyone navigating the uncertainty of a serious illness. With insights from Dr. Helen Eshed, a board-certified gynecologic oncologist and Gail’s treating physician, this conversation blends personal experience with expert guidance to help you feel more prepared, empowered, and informed—whether for yourself or someone you love.Together, they discuss when and why to seek a second opinion, including the importance of trusting your gut and asking your doctor how frequently they handle cases like yours. Dr. Bobby emphasizes the importance of finding a quarterback—a single provider who can oversee and coordinate all aspects of care, a role often filled by the medical oncologist or, in fortunate cases like Gail’s, by a specialist like Dr. Eshed who guides every step of the journey. They explore the nuanced role of the primary care physician, who may not lead cancer care but is critical in managing other chronic conditions and general health during treatment.Dr. Bobby and Dr. Eshed also confront the flood of non-evidence-based treatments patients often encounter. Supplements, restrictive diets, and alternative therapies may be well-intentioned, but many lack credible evidence and can even interfere with medical treatments. Dr. Eshed underscores the importance of open communication with your doctor to discern helpful integrative therapies—such as acupuncture or massage—from those that may be harmful. If you’re unsure, bring it to your physician and evaluate together.Another theme they unpack is the human need for agency during illness. Dr. Bobby highlights a randomized controlled trial in colon cancer survivors showing that a structured exercise program led to a 28% improvement in recurrence-free survival over eight years. This suggests that lifestyle changes like physical activity can make a real difference, even after diagnosis. But as he cautions, not everything promising on the internet is supported by research—so choose wisely and stay grounded in science.They also touch on the emotional and spiritual dimensions of illness. From the rollercoaster of diagnoses to unexpected rituals like a gratitude ceremony for Gail’s uterus, Dr. Bobby emphasizes the value of community, spiritual support, and patient-centered rituals that help bring meaning to the process. Resources like survivorship counseling and disease-specific nonprofits can offer both information and connection during the journey.Finally, they discuss the often-overlooked financial impact of serious illness. With treatments like surgery and immunotherapy costing thousands—even hundreds of thousands—of dollars, Dr. Bobby encourages listeners to proactively ask about costs, insurance coverage, and out-of-pocket maximums to avoid being blindsided.Takeaways:Ask the right questions early—about your diagnosis, treatment options, prognosis, and whether your doctor has experience with your specific condition.Look for credible, evidence-based interventions that support your care rather than distract from it—especially when you're tempted to chase internet cures.Build a strong, multi-layered support system—medical, emotional, spiritual, and financial—to help you weather the journey ahead with resilience and clarity.Visit drbobbylivelongandwell.com to sign up for his free October 2nd workshop on how to focus your energy on the habits that truly improve health and longevity—without making it your full-time job.
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About Live Long and Well with Dr. Bobby

Let's explore how you can Live Long and Well with six evidence based pillars: exercise, good sleep, proper nutrition, mind-body activities, exposure to heat/cold, and social relationships. I am a physician scientist, Ironman Triathlete, and have a passion for helping others achieve their best self.
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