ReversABLE

Dr. Tom O'Bryan returns to ReversABLE for a wide-ranging conversation about gut health, chronic inflammation, the microbiome, environmental toxins, heavy metals, and the deeper mechanisms that may connect digestive dysfunction with systemic and neurological problems.
The conversation begins with LPS, or lipopolysaccharide—a component of the outer membrane of gram-negative bacteria. Tom explains his view that LPS deserves far more attention in discussions around inflammation and describes how increased intestinal permeability may allow inflammatory bacterial components to enter circulation and affect tissues beyond the gut.
Tom then lays out his "perfect storm" framework for chronic inflammatory disease: genetic susceptibility, environmental triggers, dysbiosis, intestinal permeability, and chronic systemic inflammation. Rather than searching for one isolated root cause, he argues that practitioners should look at the entire chain of factors contributing to a person's symptoms and ask what the immune system may be responding to.
The discussion moves into gluten and wheat, including Tom's controversial position that someone can have an immune response to wheat without experiencing obvious digestive symptoms. The episode also explores the relationship between intestinal and other epithelial barriers, including the blood-brain barrier and reproductive tissues.
From there, Josh and Tom explore chemical exposure, heavy metals, fertility, sperm DNA fragmentation, air pollution, and the challenges of interpreting heavy-metal testing. They also discuss why aggressive detoxification can be problematic and why Tom emphasizes reducing ongoing exposure rather than simply pursuing increasingly aggressive detox protocols.
Finally, Tom brings the conversation back to something much more practical: education and incremental change. His "one hour a week" principle is about making small, sustainable changes to reduce environmental and lifestyle stressors over time rather than searching for a single magic intervention.
For anyone interested in gut health, inflammation, the microbiome, immune system regulation, environmental toxins, or a root-cause approach to chronic illness, this episode offers a provocative framework for thinking differently about why the body becomes sick—and what may actually help.
 
TOPICS DISCUSSED:
LPS, Leaky Gut, And Systemic Inflammation
The Five-Part "Perfect Storm" Of Chronic Disease
Gluten, Wheat, And Immune System Activation
Heavy Metals And Total Toxic Burden
Environmental Chemicals And Everyday Toxin Exposure
Brain Inflammation, LPS, And Alzheimer's-Related Mechanisms
Fertility, Sperm DNA Fragmentation, And Paternal Toxicity
Testing For Heavy Metals, Toxins, And Immune Responses
Air Pollution, Children's Brain Health, And Generational Exposure
The One-Hour-A-Week Approach To Incremental Health Change
 
More from Dr. Tom O'Bryan:
Website: thedr.com Instagram: @thedrtomobryan
X: @theDr_com
Facebook: TheDr.Com
Youtube: theDr.com
House Plants That Absorb Toxins In The Air: thedr.com/plants
Get Dr. Tom O'Bryan's Book: You Can Fix Your Brain
Get Dr. Tom O'Bryan's Book: Autoimmune Fix
 
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What if modern veterinary care is treating the symptoms of chronic disease without addressing the conditions that created them?
In this episode of ReversABLE, Josh Dech sits down with veterinarian Dr. Judy Morgan for a wide-ranging conversation about root-cause pet health, gut health, nutrition, inflammation, the microbiome, immune function, and the growing role of holistic veterinary medicine.
Dr. Morgan shares more than four decades of veterinary experience and explains why she believes pet health has changed dramatically over the past several decades. She discusses the three issues at the center of her work: what she describes as over-vaccination, ultra-processed pet food, and overuse of medications and pesticides.
The conversation then moves into one of the most important foundations of health: nutrition. Dr. Morgan explains her approach to whole-food diets for dogs and cats, why she favors minimally processed ingredients, and how she approaches dietary changes in rescue animals and pets dealing with allergies or digestive problems.
Josh and Judy also explore the connection between lifestyle and the microbiome. Judy describes an informal comparison involving her indoor and outdoor cats and discusses differences she observed in their microbiome profiles, while emphasizing the potential importance of sunlight, soil exposure, fresh plants, movement, hunting behaviors, and environmental enrichment.
The episode also tackles controversial territory, including vaccination schedules, titers, homeopathic nosodes, pharmaceutical companies, corporate ownership of veterinary clinics, prescription diets, flea and tick medications, and the economics influencing veterinary recommendations.
For pet parents dealing with chronic allergies, digestive problems, inflammation, behavioral issues, or recurring health problems, this episode offers a broader framework for thinking about animal health: look beyond the isolated symptom and consider the animal's food, environment, behavior, microbiome, immune system, and overall lifestyle.
 
TOPICS DISCUSSED:
Vaccination Schedules, Titers, And Over-Vaccination
Pet Nutrition, Raw Feeding, And Ultra-Processed Kibble
Corporate Veterinary Medicine, Private Equity, And Pharmaceutical Influence
Whole-Animal Health And Root-Cause Veterinary Care
Pet Allergies, Chronic Inflammation, And The Microbiome
Animal Lifestyle, Stress, Behavior, And Environmental Enrichment
Chinese Veterinary Medicine And Herbal Approaches
Pet Longevity, Rescue Animals, And Disease Prevention
Food Production, Farming, And Reconnecting People With Food
Holistic Veterinary Business, Education, And Naturally Healthy Pets
 
More from Dr. Judy Morgan:
Website: naturallyhealthypets.com Instagram: @drjudymorgan
TikTok: Naturally Healthy Pets
Facebook: Dr. Judy Morgan's Naturally Healthy Pets
Youtube: Dr. Judy Morgan's Naturally Healthy Pets
Listen to Dr. Judy Morgan's Podcast: The Naturally Healthy Pets Podcast
 
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Josh Dech sits down with Jonny Mills, founder of Wealth Pilot, to discuss what happens when you stop automatically following the path society has laid out for you and begin questioning what actually creates health, fulfillment, freedom, and meaning.
Jonny shares his personal experience of becoming seriously ill shortly after relocating from London to Cape Town. After being hospitalized with severe diarrhea and eventually diagnosed with ulcerative colitis, he was told that he had a genetic condition and would need long-term medication. Jonny describes how that diagnosis became the beginning of a deeper investigation into gut health, chronic illness, the microbiome, and the root-cause question rather than the end of the conversation.
From there, the conversation expands beyond the gut.
Josh and Jonny explore how chronic stress, work, financial pressure, social expectations, relationships, and our definition of success can all influence the way we experience life. They discuss the psychological cost of constantly seeking external approval, why comparing yourself to others can become a trap, and how deliberately defining your own values can create a different form of wealth.
They also challenge the idea that traditional employment is automatically synonymous with security, discussing financial independence, entrepreneurship, investing, and the importance of building greater personal control over your future.
For anyone dealing with chronic gut issues or inflammatory conditions, the deeper message is about becoming an active participant in your own health journey—while recognizing that personal agency doesn't mean ignoring professional medical care.
This is ultimately a conversation about health, identity, responsibility, freedom, and the courage to question whether the life you're living is actually the life you want.
 
TOPICS DISCUSSED:
Taking Agency And Personal Responsibility For Your Life
Jonny's Ulcerative Colitis Journey And Questioning His Initial Diagnosis/Narrative
Risk, Fear, Uncertainty, And Making Major Life Changes
Chronic Stress, Societal Expectations, And Their Relationship To Health
Financial Freedom, Entrepreneurship, And Control Over Your Future
Discipline, Excellence, Motivation, And Doing Difficult Things Intentionally
External Validation, Identity, Self-Worth, And The Need For Approval
Comparison, Jealousy, Envy, Mentorship, And Measuring Personal Progress
The Illusion Of Job Security And Preparing For An Uncertain Future
Practical Ways To Build Autonomy Through Information, Values, And Intentional Decisions
 
More from Jonny Mills:
Substack: The Wealth Code
LinkedIn: Jonny Mills, CA
 
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What happens when the foundational microbes responsible for helping establish the infant gut microbiome begin disappearing?
In this episode of ReversABLE, Josh Dech sits down with microbiome researcher Stephanie Culler to explore one of the most overlooked factors in lifelong health: what happens to the gut microbiome during the earliest stages of life.
Stephanie shares findings from the My Baby Biome study, described as the largest U.S. study of the infant gut microbiome, including the striking observation that 25% of babies in the study had no detectable Bifidobacterium at all. Even more concerning, the team found that approximately 76% of babies had low levels of these foundational bacteria, with low or absent levels by age two associated with substantially higher risk of conditions such as food allergies, eczema, and asthma.
The conversation breaks down why Bifidobacterium—particularly Bifidobacterium infantis—matters, how human milk oligosaccharides (HMOs) act as specialized prebiotics, and how microbial metabolites can influence immune-system development and inflammation. Stephanie explains how antibiotics, C-sections, feeding practices, ultra-processed foods, low-fiber diets, and broader modernization may be reshaping the infant microbiome across generations.
Josh and Stephanie also explore whether the microbiome can be "rewilded," why some bacterial strains may be better adapted to the modern gut than older commercial strains, and the potential implications for adult gut health and inflammatory disease. They discuss research into microbiome restoration using targeted combinations of Bifidobacterium strains and HMOs.
The episode also tackles a surprisingly nuanced question: is there one ideal diet for the microbiome? Stephanie explains why different microbiome configurations may respond differently to fiber-rich, mixed, or carnivore-style diets—and why personalized nutrition may ultimately depend on the microbial ecosystem already present in an individual's gut.
For parents, prospective parents, and anyone interested in gut health, inflammation, the microbiome, immune function, and root-cause approaches to chronic disease, this conversation offers a provocative look at how early microbial exposure may influence health for decades to come.
 
TOPICS DISCUSSED:
The Infant Microbiome And Loss Of Foundational Bifidobacterium
Bifidobacterium Infantis, HMOs, Immune Development, And Inflammation
Modernization, Antibiotics, C-Sections, Formula, And Ultra-Processed Foods
Whether The Microbiome Can Be Restored Or "Rewilded"
Stephanie's My Baby Biome Research And Microbiome Mapping
Implications For Adult Gut Health, Crohn's, Colitis, Cancer, And Inflammatory Disease
Microbiome-Adapted Bacterial Strains And The Persephone Product
Diet, Fiber, Fermented Foods, Plants, And The Carnivore Debate
Pregnancy, Maternal Microbiome, And Transmission To The Infant
Microbiome Conservation, Extinction, And Banking Lost Species
 
More from Stephanie Culler:
Website: persephone.bio Instagram: @persephone.bio
TikTok: persephone.bio
 
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If you're bloated after eating, reacting to seemingly "healthy" foods, struggling with constipation or diarrhea, or living on an increasingly restrictive diet, the problem may be more complicated—and more fixable—than simply identifying the foods you're "sensitive" to.
In this episode of ReversABLE, Josh Dech sits down with gut-health practitioner Hannah Aylward for a deep conversation about food sensitivities, elimination diets, the microbiome, digestion, inflammation, and the search for root cause.
Hannah explains why she doesn't recommend relying on IgG food sensitivity testing and how these tests can potentially create unnecessary food fear, particularly when gut-barrier function is compromised. Instead of continually eliminating foods, the conversation explores what may be happening upstream: impaired digestion, low stomach acid, digestive enzyme and bile issues, microbial imbalance, gut-barrier dysfunction, and the gut-brain connection.
One of the most important themes is that there may not be a single "root cause." Hannah describes a layered approach in which several dysfunctions can interact, meaning the food someone reacts to may be a clue rather than the fundamental problem.
The episode also explores why some people struggle to tolerate fiber-rich foods, why traditionally "gut-healthy" foods such as bone broth, collagen, sauerkraut, garlic, onions, and vegetables aren't necessarily right for everyone at every stage, and why a resilient microbiome should ultimately allow someone to tolerate a wider variety of foods.
Hannah shares her own experience of spending nearly a decade on an elimination diet, dealing with severe bloating and food fear, and eventually discovering that there were deeper factors affecting her gut health—including digestion, microbial balance, environmental exposures, and the nervous system.
Finally, Josh and Hannah discuss stress and the gut-brain connection, including why "it's just stress" can be an incomplete explanation. Stress can influence digestion, stomach acid, bile, motility, and gut-barrier function—meaning psychological and physiological health cannot always be separated.
If you've tried elimination diets, probiotics, supplements, or "clean eating" and still don't understand why your gut isn't improving, this episode offers a different way to think about the problem: stop asking only what you're reacting to, and start asking why.
 
TOPICS DISCUSSED:
Food Sensitivities, Intolerances & Allergies
IgG Food Sensitivity Testing And Why Hannah Doesn't Recommend It
Root Causes Behind Food Reactions
Elimination Diets, Food Restriction & Restoring Food Tolerance
Gut Microbiome, Microbial Diversity & Fiber Tolerance
Hannah's Personal Journey With Chronic Digestive Issues And Restrictive Eating
Low Stomach Acid, Digestion, Enzymes, Bile & SIBO
Carnivore Vs. Plant/Fiber Approaches And Individualized Nutrition
Gut-Brain Connection, Stress & Nervous-System Regulation
Mold Exposure, Environmental Factors & Broader Systemic Contributors
 
More from Hannah Aylward:
Website: hannahaylward.com Instagram: @hannahaylwardhhc
TikTok: HAN | Functional Gut Health
Facebook: HAN - Hannah Aylward Nutrition
Listen To Hannah's Podcast: The NUTRIENT DENSE Podcast
Take The Gut Health Root Cause Quiz For Free: Root Cause Quiz
Book A Strategy Call With Hannah: HAN Free Strategy Session
 
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