Biomarkers are one of the most exciting and fast-evolving areas in multiple sclerosis research, offering promise for earlier diagnosis, accurate prognosis, and truly personalised treatment. Yet despite their potential, there is still significant debate that limits their widespread application in clinical and research settings. In this episode, host Brett Drummond is joined by two leading voices in this field, Professor Charlotte Teunissen of Amsterdam UMC in The Netherlands and Associate Professor Michael Khalil of Medical University of Graz in Austria to explore the most promising biomarker candidates and when and how they might be implemented.
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25:48
BTK Inhibitors: The Tolebrutinib Trial Results
Over the past few years, the MS research community has been following developments in a new class of therapies called Bruton's tyrosine kinase inhibitors (BTKis). At ECTRIMS 2024, the results of two tolebrutinib trials were presented as late-breaking abstracts by Dr. Robert Fox, Neurologist at the Mellen Center for Multiple Sclerosis at Cleveland Clinic in the US, and Dr. Jiwon Oh, Neurologist at St. Michael's Hospital at the University of Toronto. The full results were recently published in The New England Journal of Medicine. In this episode, host Brett Drummond of MStranslate spoke with Drs. Oh and Fox about the outcomes and what they mean for people with MS.
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25:07
The Role of Diet in Managing MS
What do the latest research findings tell us about the role diet can play in the management of multiple sclerosis (MS)? How should neurologists talk about diet with their patients? While people living with MS may view their food choices as a way to exert some control over the disease, the concept of an "ideal diet" remains hotly contested. Dr. Brigit de Jong, Neurologist at MS Center Amsterdam, investigates non-pharmacological interventions, including diet, that determine the clinical outcome and pathogenesis of MS. She joins host Brett Drummond of MSTranslate to discuss the latest evidence on dietary modifications and how they should be communicated and implemented by neurologists.
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28:46
Autologous Haematopoietic Stem Cell Transplantation for MS
Autologous haematopoietic stem cell transplantation (AHSCT) has gained considerable attention in recent years as a treatment option for multiple sclerosis (MS). As long-term clinical trial data on AHSCT continues to grow, there is increasing debate about where it fits in the current MS therapeutic landscape. Dr. Joachim Burman, Neurologist and Associate Professor at Uppsala University in Sweden, and Dr. Jennifer Massey, Neurologist at St. Vincent's Hospital and a Senior Lecturer at the University of New South Wales in Australia, discuss the latest research and insights on this hot topic with host Brett Drummond of MStranslate.
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29:43
How Real-World Data Is Shaping MS Treatment
The rise of multiple sclerosis (MS) registries worldwide has transformed MS research, providing access to vast clinical data spanning years. This development also triggers critical conversations about how best to use real-world data to answer questions over the treatment of people with MS and the potential shift towards personalised medicine. In this episode, guests Professor Tomas Kalincik, Head of the Clinical Outcomes Research (CORe) Unit at the University of Melbourne and the MS Centre at the Royal Melbourne Hospital in Australia, and Maria Pia Sormani, Professor of Biostatistics at the University of Genoa in Italy, share their expert insights on harnessing real-world data with host Brett Drummond of MStranslate.
The world is better when its people are connected. The ECTRIMS Podcast aims to be a sounding board for MS experts & advocates to discuss innovative work in MS research, treatment and care with the greater MS research community, while offering a collaborative platform for MS and healthcare experts to promote & nurture the advancement of research.
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