The Energy Balance Podcast

Check out the Energy Balance Food Guide here: https://ww.jayfeldmanwellness.com/guide/   Timestamps: 0:00 – intro  1:03 – introducing Andrew Wallen 
 1:50 – Andrew’s background in sports, powerlifting, bodybuilding, and Brazilian Jiu-Jitsu 
 6:20 – Andrew’s experience cycling through various dietary camps (CICO, paleo, ancestral, carnivore, fasting, low-carb, etc.) 
 12:04 – whether we should shape our diets around what our ancestors did 
15:15 – how low-carb, keto, and fasting diets elevated stress and caused blood sugar issues for Andrew 
 20:45 – “optimal” blood glucose, HRV, and resting heart rate despite crashing health 
 23:50 – how stress-inducing (hormetic) health practices led to binging, self-blame, low brain energy, high blood pressure, and weakened immune function 
 27:36 – low-carb, keto, carnivore, fasting, and fear about reintroducing carbs 
 33:13 – Andrew’s breaking point with health and what led him to start questioning what being “healthy” really meant 
 36:27 –exercise intolerance, fatigue, pre-diabetes, high blood pressure, brain fog, gut issues, slow motility, and poor sleep: the product of years of low-carb and fasting 

https://www.jayfeldmanwellness.com/healthy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/non-toxic-product-recommendations-for-your-home-body-cookware-skincare-clothing-emfs-more/   Timestamps: 0:00 – intro  0:53 – misconceptions regarding the Randle cycle in the alternative health world  4:57 – what is the Randle cycle?  7:06 – what most people get wrong about the Randle cycle  10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio  16:29 – how fat oxidation inhibits the utilization of carbohydrates  21:03 – the Randle cycle shows the benefits of burning carbs for energy  25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d  26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging  32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization  38:39 – how glucose oxidation inhibits the uptake and utilization of fats  45:32 – whether you can “activate” or “deactivate” the Randle cycle  47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production  52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel  53:17 – whether we should strive for metabolic flexibility  55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing  1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state  1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle?  1:08:08 – different cells, tissues, and organs can use different fuels at the same time   

In this episode we discuss:   How the Randle Cycle actually works Whether eating carbs and fats in the same meal causes weight gain and insulin resistance The efficiency of using fats as a fuel vs carbohydrate How stress impacts fuel usage in the mitochondria How to determine the optimal amount of carbs and fats in your diet Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-139-the-truth-about-the-randle-cycle-why-you-can-eat-carbs-and-fats-together/   Timestamps: 0:00 – intro  0:53 – misconceptions regarding the Randle cycle in the alternative health world  4:57 – what is the Randle cycle?  7:06 – what most people get wrong about the Randle cycle  10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio  16:29 – how fat oxidation inhibits the utilization of carbohydrates  21:03 – the Randle cycle shows the benefits of burning carbs for energy  25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d  26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging  32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization  38:39 – how glucose oxidation inhibits the uptake and utilization of fats  45:32 – whether you can “activate” or “deactivate” the Randle cycle  47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production  52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel  53:17 – whether we should strive for metabolic flexibility  55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing  1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state  1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle?  1:08:08 – different cells, tissues, and organs can use different fuels at the same time   

In this episode we discuss:   How glucose and insulin decrease glycation Why ketogenic diets can be worse than high-carb diets when it comes to AGE formation How autophagy helps to clear AGEs, but increasing autophagy is not the answer The true primary drivers of AGE accumulation The best diet and supplements for minimizing glycation   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-138-low-carb-diets-increase-glycation-and-what-to-do-instead/   Timestamps: 0:00 – intro  0:57 – how glycation products are detoxified and cleared from the body  4:03 – glycation detoxification is impaired by oxidative stress and inflammation, as seen in type 2 diabetes  7:56 – the benefits of carbohydrates for the detoxification of glycation products  10:42 – the benefits of insulin for the detoxification of glycation products  12:45 – how AGEs are cleared  14:36 – increasing autophagy via hormesis is not the answer for clearing AGEs  19:09 – autophagy can drive disease  20:50 – ATP protects against oxidative stress and allows for proper autophagy when needed  24:37 – impaired mitochondrial along with fatty acid oxidation impairs autophagy and increases oxidative stress  26:54 – carbohydrates do NOT inhibit autophagy  29:18 – adequate thyroid hormone supports proper autophagy  30:15 – adequate ATP and mitochondrial function is needed for the UPS (ubiquitin proteasome system)  32:56 – do high-carb diets actually impair metabolism and insulin sensitivity  35:26 – is fructose really worse for blood sugar regulation and glycation?  37:16 – are low-carb or ketogenic diets the solution to reduce glycation?  40:32 – increased glycation and oxidative stress on ketogenic diets  44:09 –low-carb diets don’t prevent glucose exposure  47:56 – there are still considerable insulin and glucose excursions on low-carb diets  50:06 – gluconeogenesis leads to same glycolytic intermediates as glucose metabolism  51:52 –the main driver of AGE formation and impaired AGE clearance  53:40 – the role of vitamin B1 (thiamine) and mitochondrial energy production in decreasing AGEs  56:27 –endotoxin as a driver of glycation and increased AGE production  58:12 – hypothyroidism as a driver of glycation and AGE accumulation  59:37 – dietary solutions for reducing glycation and AGEs  1:03:33 – how to support the glyoxalase pathway to support the detoxification of glycation products  1:05:56 – avoid calorie restriction, low-carb diets, fasting, resveratrol, cold exposure, excess exercise, and iron overload to decrease glycation and AGEs  1:07:33 – iron as a double-edged sword for oxidative stress 

In this episode we discuss:   Why glucose and fructose are not the primary drivers of AGE formation Whether blood sugar spikes cause glycation How fats and ketones can cause glycation What’s really responsible for glycation in type 2 diabetes Whether fructose causes more glycation than glucose   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-137-what-really-causes-glycation-is-sugar-really-the-problem/   Timestamps: 0:00 – intro  0:46 – common beliefs about carbohydrates and glycation  2:35 – what are glycation and advanced glycation end products?  6:57 – the process of glycation from glucose  9:30 – is sugar the only source of AGEs?  15:00 – primary drivers of glycation: dicarbonyls  19:30 – how fatty acids, amino acids, and ketones cause AGE formation  21:23 – how increased gluconeogenesis on low-carb diets increases AGE formation  22:53 – glucose metabolism produces very few glycation products in the context of a healthy metabolism  25:33 – omega-6s form AGEs more than 10x faster than glucose  28:24 – the role of ALEs (advanced lipoxidation end products) in glycation and chronic disease  30:36 – whether blood sugar spikes cause glycation  38:52 – whether fructose causes more glycation (or fructation) than glucose  47:05 – can glycation from fructose (fructation) be measured, and does this matter?  52:06 – problems with research looking at fructose’s AGE formation in animal models