The Evidence Based Rheumatology Podcast

Today I cover the recent publication of the RESET-RA study, which evaluated vagal nerve stimulation to treat rheumatoid arthritis. Have a listen in full, but let me be clear upfront: I do not think this works and will not be referring any patients to receive it. This will forever be my pivotal example of the effect of unblinding, but would love to hear if you think different! 

 

Paper: https://www.nature.com/articles/s41591-025-04114-7

Supplement (see S4): https://www.nature.com/articles/s41591-025-04114-7#Sec27

Surprisingly (unbelievably?) impressive RCT evaluating the Blys/APRIL inhibitor "telitacicept" for patients with SLE (mixed SLE and SLE-LN). Very curious to see where the FDA goes with this one. 

 

Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2414719

Ever wonder how often you really need to check "monitoring" labs? If so then this is the podcast for you! Bryant England mentioned this during his excellent Year in Review session at ACR Convergence 2025. I've been meaning to cover it and finally got around to doing so. Have a listen and share with friends!

 

Paper: https://pubmed.ncbi.nlm.nih.gov/40854212/

Covering a very interesting study this week, which investiaged the PDE4B inhibitor nerandomilast for patients with progressive pulmonary fibrosis (specifically including 325 patients with autoimmune ILD). Would have been yet another ho hum trial if not for the big reveal... have a listen to find out!

Article: https://www.nejm.org/doi/full/10.1056/NEJMoa2503643

Another episode looking into safety this week! Tackling that pesky issue of TNFs and CHF. Be sure to subscribe to my newsletter and check out the papers below! 

 

Newsletter: https://sprw.io/stt-ee87b4

ATTACH: https://pubmed.ncbi.nlm.nih.gov/12796126/

RENEWAL: https://www.ahajournals.org/doi/10.1161/01.cir.0000124490.27666.b2

Observational Studies: https://pubmed.ncbi.nlm.nih.gov/23155221/