New RCT in a new disease with a new drug! But is it as shiny as one would hope? Interesting discussion today about what a trial means, how it will affect practice, and how we could do better as a field. Happy holidays everyone!Â
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12:55
E116: A New Paradigm for PMR
Reading one of my recent newsletters this week, this one about PMR tapers. Be sure to subscribe at ebrheum.com if you want access to the visuals and upcoming editions!Â
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9:29
E115: Benralizumab for EGPA - the MANDARA Study
Quick rundown of an important rheumatology RCT this week, discussing the IL-5 inhibitor benralizumab for the treatment of relapsing/refractory EGPA.Â
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MANDARA Study:Â https://www.nejm.org/doi/full/10.1056/NEJMoa2311155
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9:52
E114: Target Trials and STAR-RA with Rishi Desai
Important methodology podcast this week, covering a lot of ground with expert epidemiologist Rishi Desai. Really enjoyed our conversation and glad to be publishing today!Â
**House Keeping Note: we actually recorded this ~15 months ago but I somehow lost the audio... which somehow re-appeared! #technologyÂ
STAR-RA: https://pubmed.ncbi.nlm.nih.gov/35027405/
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31:15
E113: CAR-T is Coming to Rheumatology
Exciting podcast this week about the upcoming / impending use of CAR-T in rheumatology. Highly recommend rheumatologists learn about this now; it's going to be a big thing for many years to come. In a future episode I will lay out my case for skepticism, but for now I think a good run down of the first big published series will be enough!Â
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NEJM CAR-T Case Series: https://www.nejm.org/doi/full/10.1056/NEJMoa2308917
Nature Review Article: https://www.nature.com/articles/s41584-024-01139-z
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