What Do We Need To Know About Pregnancy, and Family Planning for Patients Diagnosed With Chronic Myeloid Leukemia?
Drs Michael J. Mauro and Jane F. Apperley answer key questions about pregnancy and family planning for patients diagnosed with chronic myeloid leukemia, including complications and treatment options. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989029). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Managing Women of Childbearing Age With Chronic Myeloid Leukemia: Safety and Treatment Considerations https://pubmed.ncbi.nlm.nih.gov/37038615/ New Challenges in Human in Vitro Fertilization https://pubmed.ncbi.nlm.nih.gov/8493531/ Treatment of CML in Pregnancy https://pubmed.ncbi.nlm.nih.gov/36485083/ Outcome of Pregnancy in Chronic Myeloid Leukaemia Patients Treated With Tyrosine Kinase Inhibitors: Short Report From a Single Centre https://pubmed.ncbi.nlm.nih.gov/25455655/ Treatment-Free Remission: the New Goal in CML Therapy https://pubmed.ncbi.nlm.nih.gov/34618317/ The Effects of Imatinib on Pregnancy Outcome https://pubmed.ncbi.nlm.nih.gov/18322153/ Stage Specific Requirement of Platelet-Derived Growth Factor Receptor-Α in Embryonic Development https://pubmed.ncbi.nlm.nih.gov/28934221/
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26:33
State of the Art Monitoring and Diagnostics in Chronic Myeloid Leukemia: the Philadelphia Chromosome and Future of CML
Drs Michael J. Mauro and Jerald P. Radich discuss monitoring and diagnostics in chronic myeloid leukemia, including the Philadelphia chromosome and how it plays into the current treatment of CML. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989028). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Chronic Myelogenous Leukemia (CML) https://emedicine.medscape.com/article/199425-overview Genetics, Philadelphia Chromosome https://www.ncbi.nlm.nih.gov/books/NBK560689/ Reverse Transcriptase-Polymerase Chain Reaction https://emedicine.medscape.com/article/2093395-overview Why Is It Critical to Achieve a Deep Molecular Response in Chronic Myeloid Leukemia? https://pubmed.ncbi.nlm.nih.gov/33054104/ Precision Oncology: Who, How, What, When, and When Not? https://ascopubs.org/doi/full/10.1200/EDBK_174176 Discovery of the Philadelphia Chromosome: A Personal Perspective https://pubmed.ncbi.nlm.nih.gov/17671636/ Dr. Janet Davison Rowley https://cfmedicine.nlm.nih.gov/physicians/biography_282.html Metaphase https://www.genome.gov/genetics-glossary/Metaphase A Primer on Genetic Testing https://www.medscape.com/viewarticle/505220_7 WHO 2016 Definition of Chronic Myeloid Leukemia and Tyrosine Kinase Inhibitors https://pubmed.ncbi.nlm.nih.gov/31612694/ Flow Cytometry: An Overview https://pubmed.ncbi.nlm.nih.gov/29512141/ Accelerated Phase Chronic Myelogenous Leukemia https://www.cancer.gov/publications/dictionaries/cancer-terms/def/accelerated-phase-chronic-myelogenous-leukemia Treatment-Free Remission in CML: Who, How, and Why? https://pubmed.ncbi.nlm.nih.gov/29222243/ Digital PCR for BCR-ABL1 Quantification in CML: Current Applications in Clinical Practice https://pubmed.ncbi.nlm.nih.gov/33283168/ Tyrosine Kinase Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK563322/ t(14;18) Translocations and Risk of Follicular Lymphoma https://pubmed.ncbi.nlm.nih.gov/18648003/ CHIP https://www.cancer.gov/publications/dictionaries/genetics-dictionary/def/chip The Max Foundation https://themaxfoundation.org/ BCR-ABL Fusion Gene https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene
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20:42
How Does the History of Chronic Myeloid Leukemia Inform the Future of Diagnosis, Treatment, Resistance, and Cure?
Drs Michael J. Mauro and Michael W. Deininger discuss the evolution of chronic myeloid leukemia, better access to treatment, improved global cure rates, and a clearer definition of the word cure. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989027). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia https://pubmed.ncbi.nlm.nih.gov/11287972/ A Phase 2 Study of Imatinib in Patients With Relapsed or Refractory Philadelphia Chromosome-positive Acute Lymphoid Leukemias https://pubmed.ncbi.nlm.nih.gov/12200353/ International CML Foundation https://www.cml-foundation.org/ Resistance to Imatinib: Mechanisms and Management https://pubmed.ncbi.nlm.nih.gov/16316612/ Ponatinib Dose-ranging Study in Chronic-phase Chronic Myeloid Leukemia: A Randomized, Open-label Phase 2 Clinical Trial https://pubmed.ncbi.nlm.nih.gov/34407543/ Asciminib Monotherapy in Patients With CML-CP Without BCR::ABL1 T315I Mutations Treated With at Least Two Prior TKIs: 4-year Phase 1 Safety and Efficacy Results https://pubmed.ncbi.nlm.nih.gov/36949155/ Cardiotoxicity of the BCR-ABL1 Tyrosine Kinase Inhibitors: Emphasis on Ponatinib https://pubmed.ncbi.nlm.nih.gov/32470534/ A Kinase Inhibitor Which Specifically Targets the ABL Myristate Pocket (STAMP), but Unlike Asciminib Crosses the Blood-brain Barrier https://pubmed.ncbi.nlm.nih.gov/35065232/ Olverembatinib (HQP1351), a Well-tolerated and Effective Tyrosine Kinase Inhibitor for Patients With T315I-mutated Chronic Myeloid Leukemia: Results of an Open-label, Multicenter Phase 1/2 Trial https://pubmed.ncbi.nlm.nih.gov/35982483/
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20:22
Developments and Challenges in the Therapeutic Landscape of Chronic Myeloid Leukemia
Drs Michael J. Mauro and Jorge E. Cortes discuss developments in the therapeutic landscape of chronic myeloid leukemia, complexities of resistance, and the potential for treatment-free remission. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989026). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Chronic Myelogenous Leukemia (CML) https://emedicine.medscape.com/article/199425-overview Tyrosine Kinase Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK563322/ Chronic Myelogenous Leukemia (CML) Treatment Protocols https://emedicine.medscape.com/article/2005453-overview Monitoring Molecular Response in Chronic Myeloid Leukemia https://pubmed.ncbi.nlm.nih.gov/20960522/ Accelerated Phase Chronic Myelogenous Leukemia https://www.cancer.gov/publications/dictionaries/cancer-terms/def/accelerated-phase-chronic-myelogenous-leukemia The 5th Edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms https://pubmed.ncbi.nlm.nih.gov/35732831/ International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: Integrating Morphologic, Clinical, and Genomic Data https://pubmed.ncbi.nlm.nih.gov/35767897/ International Chronic Myeloid Leukemia Foundation https://www.cml-foundation.org/ Sokal Score for CML https://reference.medscape.com/calculator/559/sokal-score-for-cml Treatment-Free Remission: The New Goal in CML Therapy https://pubmed.ncbi.nlm.nih.gov/34618317/ Hematopoietic Stem Cell Transplantation (HSCT) https://emedicine.medscape.com/article/208954-overview Imatinib (Rx) https://reference.medscape.com/drug/gleevec-imatinib-342239 BCR-ABL Fusion Gene https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene Ph-like Acute Lymphoblastic Leukemia https://pubmed.ncbi.nlm.nih.gov/28972016/ Next-Generation Sequencing for BCR-ABL1 Kinase Domain Mutation Testing in Patients With Chronic Myeloid Leukemia: A Position Paper https://pubmed.ncbi.nlm.nih.gov/31801582/ ASXL1 Gene https://medlineplus.gov/genetics/gene/asxl1/ Asciminib https://reference.medscape.com/drug/scemblix-asciminib-4000255 The Specificity of Asciminib, a Potential Treatment for Chronic Myeloid Leukemia, as a Myristate-Pocket Binding ABL Inhibitor and Analysis of Its Interactions With Mutant Forms of BCR-ABL1 Kinase https://pubmed.ncbi.nlm.nih.gov/33096322/ ATP-Competitive Inhibitors Modulate the Substrate Binding Cooperativity of a Kinase by Altering Its Conformational Entropy https://pubmed.ncbi.nlm.nih.gov/35905186/ Ponatinib (Rx) https://reference.medscape.com/drug/iclusig-ponatinib-999800
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20:25
Targeted Therapy and Evolving Research: Where Are We Winning and Losing in Chronic Myeloid Leukemia?
Drs Michael J. Mauro and Ehab Atallah discuss current chronic myeloid leukemia research, where the US stands in comparison with the world, and the important work being conducted by the Cure CML Consortium. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989025). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Chronic Myelogenous Leukemia (CML) https://emedicine.medscape.com/article/199425-overview Tyrosine Kinase Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK563322/ BCR-ABL Fusion Gene https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene Trastuzumab/Hyaluronidase (Rx) https://reference.medscape.com/drug/herceptin-hylecta-trastuzumab-hyaluronidase-1000345 H. Jean Khoury Cure CML Consortium https://curecml.org/ Genetics, Philadelphia Chromosome https://www.ncbi.nlm.nih.gov/books/NBK560689/ National Cancer Institute Surveillance, Epidemiology, and End Results Program (SEER). Cancer Stat Facts: Leukemia — Chronic Myeloid Leukemia (CML) https://seer.cancer.gov/statfacts/html/cmyl.html Assessment of Outcomes After Stopping Tyrosine Kinase Inhibitors Among Patients With Chronic Myeloid Leukemia: A Nonrandomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/33180106/ Treatment-free Remission: The New Goal in CML Therapy https://pubmed.ncbi.nlm.nih.gov/34618317/ Monitoring Molecular Response in Chronic Myeloid Leukemia https://pubmed.ncbi.nlm.nih.gov/20960522/ Protocol Number: HJKC3-0003. Treatment Free Remission After Combination Therapy With Asciminib (ABL001) Plus Imatinib in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI Discontinuation https://clinicaltrials.gov/ct2/show/NCT04838041 Asciminib https://reference.medscape.com/drug/scemblix-asciminib-4000255 Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors https://clinicaltrials.gov/ct2/show/NCT03610971 Ruxolitinib (Rx) https://reference.medscape.com/drug/jakafi-ruxolitinib-999703 Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase https://clinicaltrials.gov/ct2/show/NCT05143840 ATP-competitive Inhibitors Modulate the Substrate Binding Cooperativity of a Kinase by Altering Its Conformational Entropy https://pubmed.ncbi.nlm.nih.gov/35905186/ The Specificity of Asciminib, a Potential Treatment for Chronic Myeloid Leukemia, as a Myristate-pocket Binding ABL Inhibitor and Analysis of Its Interactions With Mutant Forms of BCR-ABL1 Kinase https://pubmed.ncbi.nlm.nih.gov/33096322/ Ponatinib (Rx) https://reference.medscape.com/drug/iclusig-ponatinib-999800 Accelerated Phase Chronic Myelogenous Leukemia https://www.cancer.gov/publications/dictionaries/cancer-terms/def/accelerated-phase-chronic-myelogenous-leukemia Acute Myeloid Leukemia https://emedicine.medscape.com/article/197802-overview Patients' Perspectives on the Definition of Cure in Chronic Myeloid Leukemia https://pubmed.ncbi.nlm.nih.gov/30955853/ International Chronic Myeloid Leukemia Foundation https://www.cml-foundation.org/
About Medscape InDiscussion: Chronic Myeloid Leukemia
Listen to Medscape InDiscussion: Chronic Myeloid Leukemia, a podcast series where thought leaders and clinical experts share their diverse insights and practical ideas for optimizing patient care. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989022). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
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