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PodcastsHealth & WellnessMeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production
MeSsy with Christina Applegate & Jamie Lynn Sigler
Latest episode

267 episodes

  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    Christina Is Back (Part 2) with Dr. Marwa Kaisey

    20/10/2026 | 44 mins.
    In part two of their conversation, Jamie and Christina are joined by Dr. Marwa Kaisey, an Associate Professor of Neurology at Cedars-Sinai in Los Angeles.
    Send us an email: https://www.messythepodcast.com/contact
    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
    Audio Engineer: Josh Windisch
    This episode is sponsored by:
    Novartis in neuroscience
    Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.
    Ridge - One thing to pack, five ways to power! Get 10% Off @Ridge with code MESSY at https://www.Ridge.com/messy
    NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started: https://learn.nocd.com/messy





    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    Christina Is Back (Part 1)

    20/10/2026 | 35 mins.
    Christina is finally back! This week, she returns to MeSsy and joins Jamie to catch up on everything that’s been going on in her life over the past six months.
    Send us an email: https://www.messythepodcast.com/contact
    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
    Audio Engineer: Josh Windisch
    This episode is sponsored by:
    Novartis in neuroscience
    Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.
    ZocDoc - Head to https://Zocdoc.com/messy to get started and check that appointment off your to-do list!

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    Learning to Love Every Version of Yourself with Tiffani Thiessen

    13/10/2026 | 54 mins.
    This week, Jamie is joined by Tiffani Thiessen. They talk about growing up in the spotlight, navigating rejection, embracing aging, and learning to love every version of yourself.
    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
    Audio Engineer: Josh Windisch
    This episode is sponsored by:

    Novartis in neuroscience
    Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.
    Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.
    Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad
    K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code [MESSY]
    Blissy - Wake up with clearer skin, smoother hair, and cooler sleep. Use code MESSY for an extra 30% off at blissy.com/MESSY.

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui

    06/10/2026 | 57 mins.
    This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to separate your self-worth from your career, and more.
    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
    Audio Engineer: Josh Windisch
    This episode is sponsored by:
    Novartis in neuroscience
    Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.
    Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    I Don’t Have a Lot of Fight in Me Right Now

    29/09/2026 | 31 mins.
    This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons.
    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
    Audio Engineer: Josh Windisch
    This episode is sponsored by:
    Novartis in neuroscience
    Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.
    MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at https://mudwtr.com/MESSY! #mudwtrpod
    Alloy -With Alloy, your best hair isn’t behind you. Visit https://MyAlloy.com and use the code MESSY to get 20 percent off your first order. Your menopause-specialized doctor will tailor your care to your needs — plus, you get zero dollar unlimited messaging with your doctor. This code is valid on products only.

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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About MeSsy with Christina Applegate & Jamie Lynn Sigler
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
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