The Bob Harrington Show

Bob Harringson and former FDA commissioner Rob Califf discuss medical misinformation, its impact on public and individual health, and how to fight against it.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington 
Is a Long-Simmering Crisis Boiling Over? U.S. Primary Care Today
https://doi.org/10.1056/NEJMms2510425
The Global Wellness Economy Hits a Record $6.8 Trillion and Is Forecast to Reach $9.8 Trillion by 2029 https://globalwellnessinstitute.org/press-room/press-releases/the-global-wellness-economy-hits-a-record-6-8-trillion-and-is-forecast-to-reach-9-8-trillion-by-2029/ 
Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association
https://doi.org/10.1161/CIR.0000000000001078 
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17018-9/abstract 
Here's What We Know
https://weillcornell.org/heres-what-we-know 
Fifth Circuit sides with ivermectin-prescribing doctors in their quarrel with the FDA https://www.courthousenews.com/fifth-circuit-sides-with-ivermectin-prescribing-doctors-in-their-quarrel-with-the-fda/ 
SNAP Tracker: People Are Losing Food Assistance as the Republican Megabill Is Implemented https://www.cbpp.org/research/food-assistance/snap-tracker-people-are-losing-food-assistance-as-the-republican-megabill 
Chronic Conditions and Food Insecurity in US Children https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2839376 
As Unregulated Peptides Flood the Market, Clinicians Encouraged to Counsel Patients https://www.medscape.com/viewarticle/unregulated-peptides-flood-market-clinicians-encouraged-2026a1000e63
Coethia
https://coethia.com/ 
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic 
Questions or feedback, please contact news@medscape.net

Cardiologists Bob Harrington and Lisa Rosenbaum discuss the loss of trust in medicine, how it may reflect patients' desire for agency, and strategies to earn it back.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Taking Our Medicine — Improving Adherence in the Accountability Era
https://doi.org/10.1056/NEJMp1307084
Full Coverage for Preventive Medications after Myocardial Infarction (MI FREEE trial)
https://doi.org/10.1056/NEJMsa11079
Dr Rosenbaum's Not Otherwise Specified Podcast
https://not-otherwise-specified-podcast.nejm.org/
The Concierge Cure?
https://doi.org/10.1056/NEJMms2510427
Medical Education in the United States and Canada – Flexner
https://doi.org/10.1126/science.32.810.41
The Importance of Being – Abraham Verghese
https://doi.org/10.1377/hlthaff.2016.0837
Evidence-Based Medicine
https://doi.org/10.1136/bmj.312.7023.71
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net

Drs Bob Harrington and Bob Wachter discuss the use of AI in healthcare, and Dr Wachter's latest book, A Giant Leap.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
A Giant Leap. How AI Is Transforming Healthcare and What That Means for Our Future
https://www.penguinrandomhouse.com/books/776443/a-giant-leap-by-robert-wachter-md/
Revisiting the Time Needed to Provide Adult Primary Care
https://doi.org/10.1007/s11606-022-07707-x
Bob Wachter, Digital Doctor Author, Interviewed
https://www.medscape.com/viewarticle/848172
Evidence based medicine: what it is and what it isn't
https://doi.org/10.1136/bmj.312.7023.71
Your A.I. Radiologist Will Not Be With You Soon
https://www.nytimes.com/2025/05/14/technology/ai-jobs-radiologists-mayo-clinic.html
What This Computer Needs Is a Physician: Humanism and Artificial Intelligence https://doi.org/10.1001/jama.2017.19198
Reliability of LLMs as medical assistants for the general public: a randomized preregistered study
https://doi.org/10.1038/s41591-025-04074-y
Expressing stigma and inappropriate responses prevents LLMs from safely replacing mental health providers
https://arxiv.org/abs/2504.18412
Perceptions and Opinions of Patients About Mental Health Chatbots: Scoping Review
https://doi.org/10.2196/17828
User Intentions to Use ChatGPT for Self-Diagnosis and Health-Related Purposes: Cross-sectional Survey Study
https://doi.org/10.2196/47564
KFF Health Misinformation Tracking Poll: Artificial Intelligence and Health Information
https://www.kff.org/public-opinion/kff-health-misinformation-tracking-poll-artificial-intelligence-and-health-information/
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net

Cardiologist Bob Harrington talks to Mitch Elkind, chief science officer for Brain Health and Stroke at the AHA, about the heart-brain connection and why what's good for the brain is good for the heart.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association  https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078
Migraine Headache: An Under-Appreciated Risk Factor for Cardiovascular Disease in Women https://www.ahajournals.org/doi/10.1161/JAHA.119.014546
Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands
https://doi.org/10.1080/13814788.2017.1398318
Characteristics and treatment of midlife-onset epilepsy: A 24-year single-center, retrospective study
https://doi.org/10.1002/epd2.20253
Traumatic Brain Injury and Risk of Neurodegenerative Disorder
https://doi.org/10.1016/j.biopsych.2021.05.025
Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence
https://doi.org/10.3390/ijms222413488
The neuropathological diagnosis of Alzheimer's disease
https://doi.org/10.1186/s13024-019-0333-5
Failed Semaglutide for Early Alzheimer's Not the End of the Road?
https://www.medscape.com/viewarticle/failed-semaglutide-early-alzheimers-not-end-road-2025a1000y4l
Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration
https://doi.org/10.1161/circulationaha.121.055018
Reduced regional cerebral blood flow in patients with heart failure
https://doi.org/10.1002/ejhf.874
Heart-brain Interactions in Heart Failure
https://doi.org/10.15420/cfr.2018.14.2
While You Were Sleeping, the Brain's 'Waste Disposal System' Was at Work
https://www.medscape.com/viewarticle/while-you-were-sleeping-brains-waste-disposal-system-was-2025a1000mbb
Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder
https://doi.org/10.1001/jamapsychiatry.2024.3599
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356
"VOODOO" Death https://ajph.aphapublications.org/doi/full/10.2105/AJPH.92.10.1593
Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome https://doi.org/10.1093/braincomms/fcaf299
Unlocking Longevity: Aging Reimagined  https://www.medscape.com/viewarticle/1002241
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net

Drs Harrington and Gibson's annual review of cardiovascular medicine: ACS guidelines, antiplatelet management, GLP-1s, and ever lower LDL-C with drugs or even gene editing are among the highlights.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
New ACS Guidelines
2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes
https://doi.org/10.1161/CIR.0000000000001309
ACS Guideline Chair and Vice-Chair Discussion
https://www.medscape.com/viewarticle/acs-guidelines-2025-key-points-chair-and-vice-chair-2025a100093l
Antiplatelet/Antithrombotic Strategies
Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI
https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt
Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes (NEO-MINDSET)
https://www.nejm.org/doi/full/10.1056/NEJMoa2507980
Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC)
https://www.nejm.org/doi/full/10.1056/NEJMoa2507532
Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making : ENGAGE AF-TIMI 48 Trial Analysis
https://doi.org/10.1016/j.jacadv.2025.102504
Factor XI Inhibitors
Bristol Myers, J&J Stop Blood Clotting Drug Trial After Interim Review
https://www.medscape.com/s/viewarticle/bristol-myers-j-j-stop-blood-clotting-drug-trial-after-2025a1000vqu
Bayer's Asundexian Met Primary Efficacy and Safety Endpoints in Landmark Phase III OCEANIC-STROKE Study in Secondary Stroke Prevention https://www.bayer.com/en/us/news-stories/oceanic-stroke
OAC-Naive Subgroup From OCEANIC-AF Published
https://www.medscape.com/viewarticle/novel-blood-thinner-shows-promise-atrial-fibrillation-2025a10008lz
GLP-1 and Myotrophic Drugs
Lilly's Next-gen Drug Shows Greater Weight Loss Than Zepbound in Late-stage Trial (TRIUMPH-4)
https://www.medscape.com/s/viewarticle/lillys-next-gen-drug-tops-zepbound-weight-loss-late-stage-2025a1000ys1
Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial
https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf
CRISPR and Lipid Lowering
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease
https://www.nejm.org/doi/full/10.1056/NEJMoa2504747
Gene Therapy Shows Lipid Improvement but Raises Flags
https://www.medscape.com/viewarticle/gene-therapy-shows-lipid-improvement-raises-flags-2025a1000uzw
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3
https://www.nejm.org/doi/full/10.1056/NEJMoa2511778
Evolocumab in Patients without a Previous Myocardial Infarction or Stroke (VESALIUS-CV)
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2514428
Prehospital GLP IIb/IIIa
Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction (CELEBRATE) https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net