PodcastsHealth & WellnessThe Dr. Brighten Show

The Dr. Brighten Show

Dr. Jolene Brighten
The Dr. Brighten Show
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148 episodes

  • The Dr. Brighten Show

    Why Perimenopause Hormone Therapy Can Make Symptoms Worse: Gut, Liver, Thyroid, and Toxin Factors | Pamela Langenderfer

    12/05/2026 | 50 mins.
    Have you ever started perimenopause hormone therapy and expected relief, only to feel more bloated, more irritable, more tired, or more in the grip of insomnia instead? If that sounds familiar, you are not imagining it. In this episode, I talk with Dr. Pamela Langenderfer about why hormones can be an important tool, but not the whole story.

    A prescription is only one piece of the puzzle. What your body can metabolize, clear, and tolerate matters just as much as the hormone itself. That means the gut, liver, thyroid, bowel habits, histamine load, and environmental exposures may all influence whether hormone therapy helps or feels like one more thing your body has to manage.

    This is the conversation I want more women to hear before they assume they simply need a higher dose, a different hormone, or another supplement. Sometimes the real question is not, “What hormone should I add?” It is, “What is getting in the way of my body responding well?”

    This Episode Is Brought to You By

    Dr. Brighten Essentials 

    Want science-backed supplements formulated by a doctor who actually understands women’s health? 🌿 At Dr. Brighten Essentials, every product is crafted to support your hormones, boost your energy, and help you feel your best—inside and out. From targeted nutrients for glowing skin to essentials that fuel your daily vitality, you’ll get the highest-quality ingredients in forms your body can truly use.

    Exclusive for podcast listeners: Use code POD15 at checkout for 15% off your order.

    Shop now https://drbrightenessentials.com

    HigherDOSE – Red Light Showerhead Filter

    Your shower water could be impacting your skin more than you think. The HigherDOSE Red Light Showerhead Filter features a 10-stage filtration system designed to reduce chlorine, VOCs, and other contaminants that can contribute to dryness and irritation. It also includes built-in red light therapy to support cellular energy and overall skin appearance—turning your daily shower into a more restorative ritual.

    Save 15% at http://higherdose.com/drbrighten and use code DRBRIGHTEN15 for 15% off

    LUMEBOX

    Ready to take your skincare results to the next level—right from home? 💡 LUME Box delivers professional-grade LED light therapy in a sleek, easy-to-use device that targets fine lines, pigmentation, and dullness at the cellular level. Just minutes a day can help boost collagen, calm inflammation, and reveal that lit-from-within glow. It’s the same science trusted in top dermatology clinics, now in your hands.

    Shop now → https://drbrighten.com/lumebox use code drbrighten for our exclusive community discount on your purchase.

    Links Mentioned in This Episode

    Dr. Pamela Langenderfer’s website: https://drlangenderfer.com/

    Dr. Pamela Langenderfer’s Instagram: https://www.instagram.com/drpamlangenderfer

    Dr. Pamela Langenderfer’s Facebook: https://www.facebook.com/DrLangenderfer/

    👩🏻‍⚕️Follow Dr. Jolene Brighten:

    💻 Website:⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.drbrighten.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    📸  Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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    🧵Threads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.threads.net/@drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🌟 Grab my free hormone friendly recipes here! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drbrighten.com/hormonekit/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🎧 Subscribe to the Podcast:

    Apple: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://podcasts.apple.com/us/podcast/the-dr-brighten-show/id1786362161⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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    👉 If you found this episode valuable, drop a comment below to tell us what you loved most, and share it with a friend! Let’s spread the knowledge. 💬
    Learn more about your ad choices. Visit megaphone.fm/adchoices
  • The Dr. Brighten Show

    Why PMDD Treatment Fails: SSRIs for PMDD, Birth Control, and What Your Doctor May Be Missing

    07/05/2026 | 29 mins.
    If you have PMDD and feel like you’ve tried everything—SSRIs, birth control, progesterone, gut protocols, antihistamines, supplements, cycle tracking—and you’re still crashing every luteal phase, this episode is for you. In this episode of The Dr. Brighten Show, Dr. Jolene Brighten breaks down why PMDD treatment is not one-size-fits-all, why some women feel better on standard care while others feel worse, and how PMDD can overlap with ADHD, perimenopause, histamine issues, endometriosis, progesterone intolerance, inflammation, and brain sensitivity to hormone changes. 

    The biggest message: if your PMDD treatment has failed, you are not broken—the treatment may not have matched your biology.

    Learn more about the upcoming PMDD workshop hosted by Dr. Brighten here https://drbrighten.com/pmdd

    In this show, you’ll learn why PMDD is more than “bad PMS,” why normal hormone levels don’t rule it out, why SSRIs for PMDD can be helpful for some but not everyone, how birth control can help or hurt depending on your body, and how to tell whether your symptoms are more likely PMDD, ADHD, perimenopause, or all three. Dr. Brighten also shares why PMDD has such a complicated history in medicine, how pharmaceutical influence shaped the diagnosis, and why that history should never be used to dismiss the real suffering women experience.

    This Episode Is Brought to You By

    Dr. Brighten Essentials 

    Want science-backed supplements formulated by a doctor who actually understands women’s health? 🌿 At Dr. Brighten Essentials, every product is crafted to support your hormones, boost your energy, and help you feel your best—inside and out. From targeted nutrients for glowing skin to essentials that fuel your daily vitality, you’ll get the highest-quality ingredients in forms your body can truly use.

    Exclusive for podcast listeners: Use code POD15 at checkout for 15% off your order.

    Shop now https://drbrightenessentials.com

    Pique – Pu’er Tea Duo

    Gut health isn’t just about probiotics—it’s also about nourishing your microbiome. Pique’s Pu’er Tea Duo delivers polyphenol-rich support to help promote microbial diversity, gut lining health, and balanced digestion. Featuring Green Pu’er for antioxidant support and Black Pu’er for digestion and reduced bloating, it’s an easy daily ritual for whole-gut wellness.

    Get 20% off at https://piquelife.com/drbrighten to learn more.

    HigherDOSE – Red Light Showerhead Filter

    Your shower water could be impacting your skin more than you think. The HigherDOSE Red Light Showerhead Filter features a 10-stage filtration system designed to reduce chlorine, VOCs, and other contaminants that can contribute to dryness and irritation. It also includes built-in red light therapy to support cellular energy and overall skin appearance—turning your daily shower into a more restorative ritual.

    Save 15% at http://higherdose.com/drbrighten and use code DRBRIGHTEN15 for 15% off

    👩🏻‍⚕️Follow Dr. Jolene Brighten:

    💻 Website:⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.drbrighten.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    📸  Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🎥 TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🧵Threads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.threads.net/@drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🌟 Grab my free hormone friendly recipes here! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drbrighten.com/hormonekit/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🎧 Subscribe to the Podcast:

    Apple: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://podcasts.apple.com/us/podcast/the-dr-brighten-show/id1786362161⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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    👉 If you found this episode valuable, drop a comment below to tell us what you loved most, and share it with a friend! Let’s spread the knowledge. 💬
    Learn more about your ad choices. Visit megaphone.fm/adchoices
  • The Dr. Brighten Show

    PMDD Antihistamines: Why They May Help — and Why Histamine Isn't the Whole Story

    05/05/2026 | 28 mins.
    It seems like everywhere women turn lately, someone is talking about using Allegra or Pepcid to get through the worst days of their cycle. The stories are consistent: a few pills, and the dark cloud lifts. The question is — is it real?

    The short answer is: histamine can be involved in PMDD. But the longer, more important answer is that histamine alone is not the whole story. This episode of The Dr. Brighten Show breaks down exactly why that distinction matters — and what women deserve to know before building a routine around over-the-counter antihistamines.

    This Episode Is Brought to You By

    Dr. Brighten Essentials 

    Want science-backed supplements formulated by a doctor who actually understands women’s health? 🌿 At Dr. Brighten Essentials, every product is crafted to support your hormones, boost your energy, and help you feel your best—inside and out. From targeted nutrients for glowing skin to essentials that fuel your daily vitality, you’ll get the highest-quality ingredients in forms your body can truly use.

    Exclusive for podcast listeners: Use code POD15 at checkout for 15% off your order.

    Shop now https://drbrightenessentials.com

    Pique – Pu’er Tea Duo

    Gut health isn’t just about probiotics—it’s also about nourishing your microbiome. Pique’s Pu’er Tea Duo delivers polyphenol-rich support to help promote microbial diversity, gut lining health, and balanced digestion. Featuring Green Pu’er for antioxidant support and Black Pu’er for digestion and reduced bloating, it’s an easy daily ritual for whole-gut wellness.

    Get 20% off at https://piquelife.com/drbrighten to learn more.

    HigherDOSE – Red Light Showerhead Filter

    Your shower water could be impacting your skin more than you think. The HigherDOSE Red Light Showerhead Filter features a 10-stage filtration system designed to reduce chlorine, VOCs, and other contaminants that can contribute to dryness and irritation. It also includes built-in red light therapy to support cellular energy and overall skin appearance—turning your daily shower into a more restorative ritual.

    Save 15% at http://higherdose.com/drbrighten and use code DRBRIGHTEN15 for 15% off

    👩🏻‍⚕️Follow Dr. Jolene Brighten:

    💻 Website:⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.drbrighten.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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    🧵Threads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.threads.net/@drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🌟 Grab my free hormone friendly recipes here! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drbrighten.com/hormonekit/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🎧 Subscribe to the Podcast:

    Apple: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://podcasts.apple.com/us/podcast/the-dr-brighten-show/id1786362161⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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    👉 If you found this episode valuable, drop a comment below to tell us what you loved most, and share it with a friend! Let’s spread the knowledge. 💬
    Learn more about your ad choices. Visit megaphone.fm/adchoices
  • The Dr. Brighten Show

    High Insulin, Severe PMS, Fibroids & Postpartum Anxiety: Your Hormone AMA

    30/04/2026 | 31 mins.
    Many women are told that lab work is normal while symptoms keep getting louder. Weight-loss resistance can worsen even with a normal A1C. Mood can crash before a period even when routine testing shows nothing unusual. Anxiety can intensify after birth and still be brushed aside as part of new motherhood. Digestive symptoms can flare every luteal phase and still get labeled as nothing more than hormones.

    This Hormone AMA focuses on the gap between what patients feel and what standard care often catches. I walk through the patterns that tend to show up before a formal diagnosis appears on paper. Instead of treating these issues as separate problems, I connect insulin signaling, inflammation, progesterone, thyroid function, the gut, and the nervous system.

    That framing matters because many women are not being ignored by a single uncaring clinician. They are being managed inside a system that often waits for disease to become obvious before offering answers. This episode explains what can be happening earlier, what questions may move the conversation forward, and which warning signs should never be brushed off.

    This Episode is Sponsored By

    Dr. Brighten Essentials 

    Want science-backed supplements formulated by a doctor who actually understands women’s health? 🌿 At Dr. Brighten Essentials, every product is crafted to support your hormones, boost your energy, and help you feel your best—inside and out. From targeted nutrients for glowing skin to essentials that fuel your daily vitality, you’ll get the highest-quality ingredients in forms your body can truly use.

    Exclusive for podcast listeners: Use code POD15 at checkout for 15% off your order.

    Shop now https://drbrightenessentials.com

    HigherDOSE – Red Light Showerhead Filter

    Your shower water could be impacting your skin more than you think. The HigherDOSE Red Light Showerhead Filter features a 10-stage filtration system designed to reduce chlorine, VOCs, and other contaminants that can contribute to dryness and irritation. It also includes built-in red light therapy to support cellular energy and overall skin appearance—turning your daily shower into a more restorative ritual.

    Save 15% at http://higherdose.com/drbrighten and use code DRBRIGHTEN15 for 15% off

    LMNT Electrolytes 

    Want a clean, science-backed way to stay hydrated and energized? At LMNT, electrolytes are formulated with a precise balance of sodium, potassium, and magnesium — with no sugar, no artificial ingredients, and no unnecessary fillers. Designed to support hydration, muscle function, and daily energy, LMNT helps you feel your best through workouts, busy days, and everyday life.

    Exclusive for podcast listeners: Visit http://drinklmnt.com/Brighten to receive a free sample pack with any purchase.

    👩🏻‍⚕️Follow Dr. Jolene Brighten:

    💻 Website:⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.drbrighten.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    📸  Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🎥 TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🧵Threads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.threads.net/@drjolenebrighten⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🌟 Grab my free hormone friendly recipes here! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drbrighten.com/hormonekit/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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  • The Dr. Brighten Show

    Could GLP-1s Help Endometriosis? The Progesterone Resistance Theory

    28/04/2026 | 28 mins.
    Can a GLP-1 medication change the way progesterone works in endometriosis? That is the central question Dr. Brighten explores in this episode, and it is not a throwaway idea. It sits at the intersection of inflammation, hormone receptor signaling, and the reality that many women are told to manage endometriosis with options that reduce symptoms without stopping the disease process.

    This episode examines a novel mechanistic theory: GLP-1 agonists may help restore progesterone responsiveness by lowering inflammatory signaling inside endometriosis lesions. The conversation is careful about the evidence stage. The research is promising, but it is still emerging, and the episode makes that distinction clear while still taking women’s lived experience seriously.

    That matters because women with endometriosis are often told to accept unbearable pain, mood changes, and gut disruption as normal. This episode does not accept that as the end of the story. It asks a better question: what if the inflammatory environment is part of why progesterone stops working the way it should? This episode changes the conversation.

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About The Dr. Brighten Show

Dr. Jolene Brighten, a best-selling author, board certified naturopathic endocrinologist, and women’s health expert, hosts The Dr. Brighten Show—a podcast dedicated to igniting transformative conversations in women’s health. Through candid interviews with leading experts, innovators, and thought-leaders, this show brings you groundbreaking research, personal stories, and practical tools to help you confidently navigate your body and hormones. It’s a fun, engaging, and insightful journey designed to empower you with tangible, science-backed insights, so you can live your best, most vibrant life.
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