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The Metabolic Link

Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field
The Metabolic Link
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  • The Great Obesity Debate: Energy Balance vs Fructose - Dr. Layne Norton & Dr. Richard Johnson | Ep.70
    What’s really causing America’s obesity epidemic? In this special debate episode of The Metabolic Link, two leading voices in metabolic health square off: Dr. Richard Johnson, renowned for his research on fructose metabolism, and Dr. Layne Norton, a PhD in nutritional sciences and expert on the energy balance model. Moderated by host Dr. Dominic D’Agostino, the discussion dives deep into the biological roots of obesity, the relevance of sugar-sweetened beverages, the role of leptin and uric acid, and whether it’s fructose or calories that are driving the crisis. Despite their differing perspectives, both experts agree on one critical point—our modern food environment is fueling metabolic dysfunction on a massive scale. This is one of the most nuanced and constructive conversations you’ll hear on the topic of obesity science.References submitted by both guests can be found here!For more exclusive interviews and presentations with Dr. Johnson and Dr. Norton along with 100s of other videos on metabolic health and therapy, ad-free private episodes of The Metabolic Link, and to earn CMEs visit our member medical education platform: https://membership.metabolicinitiative.comSpecial thanks to the sponsors of this episode:✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here✅ iRestore – Get a huge discount when you use the code METABOLICLINK here✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK hereLearn more about Dr. Layne NortonLearn more about Dr. Richard JohnsonIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
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  • How Could an Animal-Based Diet Impact Metabolic Health? | Anthony Chaffee, MD | The Metabolic Link Ep.69
    Join us for a Live Q&A on June 18th at 9am PT/12pm ET with Dr. Anthony Chaffee and also enjoy ad-free exclusive episodes, videos covering the latest science on metabolic health on therapy, and earn CMEs by clicking here. In this episode, Dr. Anthony Chaffee—medical doctor, neurosurgical registrar, and nutrition educator—joins Dr. Dominic D’Agostino for a thoughtful exploration of the scientific rationale behind animal-based ketogenic diets. Together, they discuss burgeoning interest in how this approach could support metabolic health, reduce inflammation, and potentially improve outcomes in chronic conditions. Dr. Chaffee also shares his personal journey, evolutionary insights, and emerging clinical cases that invite a reexamination of modern dietary assumptions. Whether you’re a practitioner, patient, or simply curious about low-carb, ketogenic, or elimination-based nutrition strategies, this conversation offers valuable perspective on food, metabolism, and human health.Special thanks to the sponsors of this episode:✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here✅ Fatty15 – Get 15% off a 90-day Starter Kit with the code METABOLICLINK here✅ Zocdoc – Find and instantly book a top-rated doctor hereIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
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  • Bipolar Illness & Metabolic Health: My Story | Matt Baszucki | The Metabolic Link Ep.68
    Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health and therapy, and earn CMEs here!In this deeply personal and courageous episode of The Metabolic Link, we hear from patient advocate and podcast co-host Matt Baszucki, who shares how he endured—and ultimately overcame—type 1 bipolar disorder through a radical shift in treatment: ketogenic metabolic therapy.After years of hospitalizations, debilitating mood episodes, and failed conventional treatments, Matt found hope through the emerging field of metabolic psychiatry. With the help of his family, including support and clinical guidance from Dr. Christopher Palmer, Matt adopted a therapeutic ketogenic diet in 2021—and the results were extraordinary.Now a thriving project manager in Silicon Valley and co-host of The BipolarCast, Matt is helping drive a movement that challenges the very foundation of how we treat mental illness. This episode is not just about recovery—it's about transformation, resilience, and the future of mental health care.Special thanks to the sponsors of this episode:✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here✅ iRestore – Get a huge discount when you use the code METABOLICLINK hereWatch Matt Baszucki's YouTube Channel here and Bipolar Cast here. Learn more about the non-profit, Metabolic Mind, here. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
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  • Hormone Health for Performance and Longevity | Kyle Gillett, MD | The Metabolic Link Ep.67
    Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs here!If you’re a clinician, scientist, or anyone interested in taking a deep dive into the complexities of hormone regulation, this episode of The Metabolic Link Podcast is for you! Recorded live at Metabolic Health Summit 2024, this in-depth presentation by Dr. Kyle Gillett—dual board-certified in family and obesity medicine—dives deep into the biochemical, clinical, and therapeutic layers of hormone health.From his foundational “Seven Pillars of Health” to cutting-edge insights on peptides, receptor affinity, and hormone testing strategies, Dr. Gillett provides a masterclass on optimizing hormones for performance, longevity, and metabolic resilience. Designed for professionals and educated listeners alike, this talk bridges clinical relevance with scientific nuance.Access even more from Dr. Gillett—like his exclusive Hormones 101 lecture—inside our medical education platform, The Metabolic Initiative. Start your free trial at https://membership.metabolicinitiative.com.Special thanks to the sponsors of this episode:✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here✅ Fatty15 – Get 15% off a 90-day Starter Kit with the code METABOLICLINK here ✅ Zocdoc – Find and instantly book a top-rated doctor here✅ Puori – Get 20% off supplements with code METABOLICLINK hereLearn more about Dr. Gillett here!In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
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  • Journal Club: The Rise of Fatty Liver Disease and its Metabolic Roots | Ep.66
    Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs: https://membership.metabolicinitiative.comIn today's journal club episode, co-hosts of The Metabolic Link, Dr. Angela Poff and Dr. Dominic D'Agostino, unpack the startling rise of non-alcoholic fatty liver disease (NAFLD)—a silent epidemic affecting millions worldwide. Tune in as they break down groundbreaking new research revealing how NAFLD isn't just impacting adults, but alarmingly, children and adolescents too.You'll learn about the latest updates in terminology, such as Metabolic Dysfunction Associated Steatohepatitis (MASH) and Metabolic Dysfunction Associated Steatotic Fatty Liver Disease (MASLD), highlighting a critical connection to underlying metabolic dysfunction. Plus, discover exciting dietary strategies—like therapeutic carbohydrate restriction—that hold potential not just to prevent, but to actually reverse liver fat accumulation.If you've ever wondered how your diet and lifestyle choices directly shape your metabolic health, this episode delivers practical insights and actionable information straight from cutting-edge science. Don't miss this deep dive into the latest science on NAFLD—and how simple shifts today could dramatically improve your metabolic health tomorrow.Special thanks to the sponsors of this episode:Genova Connect – Get 15% off any test kit with code METABOLICLINK hereMaui Nui Venison: Gain access to a limited collection of our favorite Maui Nui products hereiRestore: Use code METABOLICLINK for exclusive discounts on the iRestore Illumina Face Mask here Puori – Get 20% off supplements with code METABOLICLINK hereRead the papers discussed here: https://pubmed.ncbi.nlm.nih.gov/38521116/ https://pubmed.ncbi.nlm.nih.gov/38914224/https://pubmed.ncbi.nlm.nih.gov/38771552/https://pubmed.ncbi.nlm.nih.gov/38723301/ In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
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About The Metabolic Link

Welcome to The Metabolic Link, a medical and science podcast that explores the common thread of metabolism in health and disease. Join Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field as they dive into the latest research on metabolic health and therapy alongside some of the world’s leading experts. They'll also discuss how this science is being applied in the real world. This is where science meets society.
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