Optimal Protein Podcast with Vanessa Spina

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Welcome back to the Optimal Protein Podcast Summer PSMF Series, where we're exploring the science, history, and practical application of protein-sparing modified fasting (PSMF), protein pacing, intermittent fasting, and evidence-based strategies for rapid fat loss while preserving lean mass.
In this episode, Vanessa is joined by Dr. Paul Arciero, professor, researcher, and creator of the Protein Pacing® approach, to discuss one of the most talked-about studies in body composition research.
His groundbreaking clinical trial found that combining protein pacing with intermittent fasting produced greater improvements in fat loss, visceral fat reduction, body composition, and cardiometabolic health than calorie restriction alone—while helping participants preserve lean mass.
Dr. Arciero explains exactly how the study was designed, why meal timing and protein distribution matter, how the fasting protocol worked, and why the quality of nutrition during both feeding and fasting periods may be critical for maximizing results.
The conversation also explores his fascinating research on toxins stored in body fat, detoxification during weight loss, autophagy, antioxidant support during fasting, and the exciting microbiome research that followed this landmark study.
In this episode, you'll learn:
Why protein pacing may outperform traditional calorie restriction
How combining intermittent fasting with protein pacing improves body composition
The ideal protein intake, timing, and meal distribution for fat loss
How to preserve lean muscle while losing fat
The thermic effect of protein and metabolic advantages of higher protein intake
The surprising role of antioxidants and adaptogens during fasting
What happens to toxins stored in fat during weight loss
How fasting influences autophagy and metabolic health
What Dr. Arciero's newest microbiome research may reveal
Connect with Dr. Paul Arciero
📖 The PRISE Life: Protein Pacing for Optimal Health and Performance
The PSMF Library is officially live 🎉
This is the exact structured, high-protein approach Vanessa used for fat loss and body recomposition — without restricting calories every single day.
Instead of guessing what to eat or starting over each week, you'll follow a clear, repeatable system combining high-protein, lower-energy days with maintenance days.
✨ What's Included
📘 Premium printed PSMF Library
⚡ Instant digital access
🥩 High-protein, low-carb recipe library
🧠 Tiered system (PSMF + maintenance days)
🛒 Grocery lists + planning tools
👥 3 months of community support
👉 Check it out here + get 20% off with code VANESSA
IQBAR – Try the Ultimate Sampler Pack: IQBARs, IQMIX, and IQJOE! Text VANESSA to 64000 for a 20% off discount code
🔴 Tone Lux Red Light Therapy
Boost collagen, elastin, and recovery
✨ Save 20% with code VANESSA
Discover:
Tone Lux Crystal Face Mask
Tone Lux Contour (neck & décolletage)
🔬 Tone Device
Vanessa uses the Tone Device as a proxy for fat loss + autophagy on PSMF days
Check it out HERE 👉 Use code VANESSA for 20% off
📚 Free Resource
Get your free high-protein keto guide:
👉 The Keto Reset eBook
👤 Connect with Vanessa
Instagram: @ketogenicgirl
📱 Follow for:
Latest fat loss research
Protein optimization strategies
🎙 @optimalproteinpodcast for episode updates
💬 Join the Optimal Protein Podcast Community on Facebook
⚠️ Disclaimer
This podcast is for informational purposes only and is not medical or nutritional advice. Always consult your healthcare provider before making dietary or lifestyle changes.

In this episode, Vanessa sits down with bestselling author, nurse practitioner, and Everyday Wellness host Cynthia Thurlow to discuss why women who enter perimenopause with more muscle and better metabolic health often experience a smoother transition.
The PSMF Library is officially live 🎉
👉 Check it out here + get 20% off with code VANESSA
They explore protein intake, intermittent fasting, testosterone, insulin resistance, gut health, inflammation, and practical strategies to preserve lean mass, improve body composition, and support long-term health.
In this episode:
Why muscle is essential for metabolic health during menopause
The connection between protein, insulin sensitivity, and fat loss
Cynthia's updated perspective on intermittent fasting
Testosterone's role in energy, cognition, motivation, and body composition
How gut health influences inflammation and weight loss resistance
Simple nutrition and lifestyle strategies to build resilience before menopause
The PSMF Library is officially live 🎉
This is the exact structured, high-protein approach Vanessa used for fat loss and body recomposition — without restricting calories every single day.
Instead of guessing what to eat or starting over each week, you'll follow a clear, repeatable system combining high-protein, lower-energy days with maintenance days.
✨ What's Included
📘 Premium printed PSMF Library
⚡ Instant digital access
🥩 High-protein, low-carb recipe library
🧠 Tiered system (PSMF + maintenance days)
🛒 Grocery lists + planning tools
👥 3 months of community support
👉 Check it out here + get 20% off with code VANESSA
🔴 Tone Lux Red Light Therapy
Boost collagen, elastin, and recovery
✨ Save 20% with code VANESSA
Discover:
Tone Lux Crystal Face Mask
Tone Lux Contour (neck & décolletage)
🔬 Tone Device
Vanessa uses the Tone Device as a proxy for fat loss + autophagy on PSMF days
Check it out HERE 👉 Use code VANESSA for 20% off
Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.
Link to join the Facebook group for the podcast
The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Protein-sparing modified fasting (PSMF) has been used for decades as one of the most effective evidence-based approaches for rapid fat loss while preserving lean muscle. But how does it actually work, and who is it best suited for?
Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code VANESSA for 20% off.
In this episode, Vanessa sits down with returning guest Dr. David Jockers to explore the science behind PSMF, why prioritizing protein changes everything during a calorie deficit, and how this approach differs from traditional fasting, keto, and fasting-mimicking diets.
They discuss ketosis, satiety, autophagy, resistance training, meal structure, protein targets, refeeding strategies, and the lifestyle habits that make rapid fat loss both more effective and more sustainable.
If your goal is fat loss without sacrificing muscle, this episode provides a practical, science-backed roadmap to implementing protein-sparing modified fasting safely and effectively.
In This Episode
What protein-sparing modified fasting (PSMF) is
How PSMF differs from fasting, keto, and fasting-mimicking diets
Why high protein supports muscle preservation during fat loss
How ketosis and protein work together to reduce hunger
The connection between PSMF, autophagy, and metabolic health
Protein, fat, and carbohydrate targets for PSMF days
The best foods to prioritize for successful PSMF
Meal timing and intermittent fasting considerations
Why resistance training is essential for preserving lean mass
Hydration, electrolytes, sleep, and recovery strategies
Refeeding after PSMF and avoiding rebound weight gain
Who should—and shouldn't—use this approach
Common mistakes that limit fat loss success
Resources
The PSMF Library is officially live 🎉
This is the exact structured, high-protein approach Vanessa used for fat loss and body recomposition — without restricting calories every single day.
Instead of guessing what to eat or starting over each week, you'll follow a clear, repeatable system combining high-protein, lower-energy days with maintenance days.
✨ What's Included
📘 Premium printed PSMF Library
⚡ Instant digital access
🥩 High-protein, low-carb recipe library
🧠 Tiered system (PSMF + maintenance days)
🛒 Grocery lists + planning tools
👥 3 months of community support
👉 Check it out here + get 20% off with code VANESSA
IQBAR – Try the Ultimate Sampler Pack: IQBARs, IQMIX, and IQJOE! Text VANESSA to 64000 for a 20% off discount code
🔴 Tone Lux Red Light Therapy
Boost collagen, elastin, and recovery
✨ Save 20% with code VANESSA
Discover:
Tone Lux Crystal Face Mask
Tone Lux Contour (neck & décolletage)
🔬 Tone Device
Vanessa uses the Tone Device as a proxy for fat loss + autophagy on PSMF days
Check it out HERE 👉 Use code VANESSA for 20% off
📚 Free Resource
Get your free high-protein keto guide:
👉 The Keto Reset eBook
👤 Connect with Vanessa
Instagram: @ketogenicgirl
📱 Follow for:
Latest fat loss research
Protein optimization strategies
🎙 @optimalproteinpodcast for episode updates
💬 Join the Optimal Protein Podcast Community on Facebook
⚠️ Disclaimer
This podcast is for informational purposes only and is not medical or nutritional advice. Always consult your healthcare provider before making dietary or lifestyle changes.

In this episode, Vanessa Spina interviews Dr. Hans H. Stein, Professor of Animal Sciences at the University of Illinois Urbana-Champaign, about protein quality, amino acid digestibility, and why "grams of protein" on a label do not always reflect what the body can actually use.
The PSMF Library is officially live 🎉
👉 Check it out here + get 20% off with code VANESSA
. Stein explains why we do not technically need protein — we need digestible indispensable amino acids — and why this matters for muscle protein synthesis, aging, pregnancy, lactation, fat loss, and body recomposition.
They discuss animal versus plant proteins, DIAAS and PDCAAS scoring, why plant-based burgers may not be biologically equivalent to animal-based burgers, how food processing can improve or damage protein quality, and why protein quality becomes even more important during calorie restriction.
This conversation will change how you think about protein labels, protein targets, and the amino acids needed to preserve lean mass while losing fat.
The PSMF Library is officially live 🎉
This is the exact structured, high-protein approach Vanessa used for fat loss and body recomposition — without restricting calories every single day.
Instead of guessing what to eat or starting over each week, you'll follow a clear, repeatable system combining high-protein, lower-energy days with maintenance days.
✨ What's Included
📘 Premium printed PSMF Library
⚡ Instant digital access
🥩 High-protein, low-carb recipe library
🧠 Tiered system (PSMF + maintenance days)
🛒 Grocery lists + planning tools
👥 3 months of community support
👉 Check it out here + get 20% off with code VANESSA
🔴 Tone Lux Red Light Therapy
Boost collagen, elastin, and recovery
✨ Save 20% with code VANESSA
Discover:
Tone Lux Crystal Face Mask
Tone Lux Contour (neck & décolletage)
🔬 Tone Device
Vanessa uses the Tone Device as a proxy for fat loss + autophagy on PSMF days
Check it out HERE 👉 Use code VANESSA for 20% off
Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.
Link to join the Facebook group for the podcast
The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

In this episode of the Optimal Protein Podcast, Vanessa is joined by Dr. Brian Mowll for a deep dive into protein-sparing modified fasting, or PSMF, as part of the Friday Protein-Sparing Modified Fasting Series.
Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code VANESSA for 20% off.
Dr. Mowll explains the origins of PSMF, how it was first developed in clinical settings to help preserve lean body mass, and why it later became a powerful tool for obesity, metabolic health, and fat loss. Vanessa and Dr. Mowll explore how PSMF compares to water fasting and very low-calorie diets, especially when the goal is fat loss while protecting muscle.
They discuss how strategic energy restriction, optimized protein intake, low carbohydrate intake, and low dietary fat can help the body access stored body fat while maintaining lean mass, metabolic rate, satiety, and ketone production. Dr. Mowll also explains how PSMF may support insulin sensitivity, blood sugar regulation, metabolic flexibility, and long-term weight maintenance when followed by a smart transition plan.
This episode also covers practical implementation, including what to eat on PSMF days, ideal protein targets, how low to take carbs and fats, hunger signals, why some people feel energized, and how to transition out of PSMF to reduce the risk of rebound weight gain.
The PSMF Library is officially live 🎉
This is the exact structured, high-protein approach Vanessa used for fat loss and body recomposition — without restricting calories every single day.
Instead of guessing what to eat or starting over each week, you'll follow a clear, repeatable system combining high-protein, lower-energy days with maintenance days.
✨ What's Included
📘 Premium printed PSMF Library
⚡ Instant digital access
🥩 High-protein, low-carb recipe library
🧠 Tiered system (PSMF + maintenance days)
🛒 Grocery lists + planning tools
👥 3 months of community support
👉 Check it out here + get 20% off with code VANESSA
IQBAR – Try the Ultimate Sampler Pack: IQBARs, IQMIX, and IQJOE! Text VANESSA to 64000 for a 20% off discount code
🔴 Tone Lux Red Light Therapy
Boost collagen, elastin, and recovery
✨ Save 20% with code VANESSA
Discover:
Tone Lux Crystal Face Mask
Tone Lux Contour (neck & décolletage)
🔬 Tone Device
Vanessa uses the Tone Device as a proxy for fat loss + autophagy on PSMF days
Check it out HERE 👉 Use code VANESSA for 20% off
📚 Free Resource
Get your free high-protein keto guide:
👉 The Keto Reset eBook
👤 Connect with Vanessa
Instagram: @ketogenicgirl
📱 Follow for:
Latest fat loss research
Protein optimization strategies
🎙 @optimalproteinpodcast for episode updates
💬 Join the Optimal Protein Podcast Community on Facebook
⚠️ Disclaimer
This podcast is for informational purposes only and is not medical or nutritional advice. Always consult your healthcare provider before making dietary or lifestyle changes.