In this episode, Vanessa breaks down the fasting mimicking diet (FMD) — including the exact calories, macros, and protein intake used in the research — and compares it to higher-protein fat loss approaches like protein-sparing modified fasting (PSMF) days.
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You'll learn what the science actually shows about fat loss, lean mass preservation, and autophagy, and why emerging human data suggests that energy restriction — not protein suppression — may be the primary driver of many fasting-related benefits.
This episode challenges the idea that protein and mTOR are "anti-longevity" and explores a more nuanced, evidence-based approach — especially for women focused on body recomposition, fat loss, and metabolic health.
🧠 In This Episode:
The exact calories and macros of the fasting mimicking diet (FMD)
What the 2017 FMD study actually showed
Why lean mass loss can occur on low-protein approaches
New 2025 human research on autophagy and protein intake
Why energy deficit — not fasting frequency — drives fat loss
What alternate-day fasting research shows about body composition
The role of protein in preserving muscle during fat loss
Why mTOR is not the enemy
The high-protein advantage for fat loss and muscle retention
📚 Studies & References
Fasting Mimicking Diet (FMD):
Wei et al., Science Translational Medicine (2017)
Brandhorst & Longo, Cell Metabolism (2019)
Autophagy & Protein Intake:
Burns et al., Clinical Nutrition (2025)
Alternate Day Fasting & Energy Restriction:
Trepanowski et al., JAMA Internal Medicine (2017)
Varady et al., Obesity Reviews (2013)
Diaz-Garrido et al., Nutrients (2026)
Protein & Lean Mass Preservation:
Morton et al., British Journal of Sports Medicine (2018)
Helms et al., JISSN (2014)
Note: The 2026 publication referenced is a review paper. Body composition outcomes discussed reflect findings from the broader alternate-day fasting literature.
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Vanessa discusses how using the Tone Device is a proxy for fat loss and autophay on Protein Sparing Modified Fasting (PSMF) days! 👉 Use code VANESSA for 20% off HERE
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🎙 The content in this podcast is for informational purposes only and not nutritional or medical advice. Always consult your healthcare provider before making major dietary or lifestyle changes.