This Week in Cardiology

Some promising studies in amyloidosis, aficamten in nonobstructive HCM, costs of the microaxial flow pump in cardiogenic shock, and more on the VESALIUS trial of evolocumab are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Light Chain Amyloidosis – A Potentially Helpful Drug
Anselamimab Does Not Reduce Light-Chain Amyloidosis Deaths
https://www.medscape.com/viewarticle/anselamimab-does-not-reduce-light-chain-amyloidosis-deaths-2026a1000z79
II Aficamten in Nonobstructive HCM: The ACACIA trial
III Microaxial Flow Pump Cost Analysis of Danger Shock
IV More on Evolocumab at ESC: Vesalius Trial Substudies
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
https://www.medscape.com/viewarticle/1003092

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Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
POET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis
POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312
POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887
II PVI-SHAM-AF trial Back in the News
GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337
PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
Why Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External Link
The Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link
III ICDs in HCM
I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597
ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687
IV Agenda Laundering
How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009
Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194
II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis
POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312
POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887
III Obesity and AF – A Neat Study from the Team in Prague
LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509
IV Reducing CAC: The DANCODE Trial
DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363
V Two Big RCTs of New GLP-1 Drugs
TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169
SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback LBBP ICD Lead
LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/
TRIC-I-HF trial
TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030
II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial
PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012
III Targeting CS leads in CRT devices – DANISH-CRT Trial
DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
IV Exercise for AF, Especially When There Is LA Disease
Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999
V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX
REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017
ROTAS Trial https://heart.bmj.com/content/110/20/1223
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Correction on PROFID Trial
II Listener Feedback
III Fifth Universal Definition of MI
Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101
Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967
IV New ESC HF Guidelines
ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100
Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20
Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/
V AIR STEMI Trial
AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373
CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051
PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
VI GLP-1 News – A SELECT Trial Secondary Analysis
Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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