LONGEVITY with Nathalie Niddam

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My guest today is James LaValle R.Ph., C.C.N. M.T. DHM, DHPh, one of the pioneers in functional and metabolic medicine, and we're unpacking the silent process he calls metaflammation—the chronic, low-grade inflammation that can quietly drive everything from fatigue and insulin resistance to hormone imbalances and accelerated aging.

Episode Timestamps:

Introduction & Why "Normal" Labs Can Be Misleading ... 00:00:00

Why Treating Symptoms Without Addressing the Cause Doesn't Work ... 00:10:53

The Cascade From Metabolic Dysfunction to Chronic Disease ... 00:13:38

Why Standard Blood Tests Often Miss Early Disease ... 00:17:08

Hidden Blood Markers & Pattern Recognition in Lab Work ... 00:19:39

Why We Normalize Feeling Bad ... 00:23:17

Empowering Patients Instead of Accepting "Getting Older" ... 00:25:05

Environmental Toxins, Mold, Heavy Metals & The Exposome ... 00:31:00

Detoxification: What Actually Works? ... 00:35:00

Finding a Practitioner Who Looks at the Whole Picture ... 00:36:53

GLP-1 Medications: Benefits, Risks & Common Misconceptions ... 00:44:20

Essential Amino Acids, Creatine & Preserving Lean Mass ... 00:58:24

Titrating GLP-1s vs. "Microdosing" ... 00:60:11

Wearables, Biomarkers & The Future of Health Tracking ... 01:26:52

Rapid-Fire Questions: Most Underrated Biomarker, Sleep & Recovery ... 01:27:10

Our Amazing Sponsors:

MitoQ Hormonal Metabolic Control – A targeted formula designed to support women through the hormonal and metabolic shifts of perimenopause and menopause, featuring S-Equol for healthy estrogen signaling, B. breve to support the gut-hormone connection, and chromium to help maintain healthy blood sugar balance. Head to MitoQ.com/nat and use code NAT10 to try it for yourself.

Nature's Marvels Bioregulators by Profound Health - Natural bioregulators designed to support your body's own cellular communication and healthy aging, with targeted formulas for everything from brain and immune health to sleep and vitality. Visit https://profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order.

C.A.R.E. Mitochondrial Moisturizer by Young Goose – An upgraded cellular skincare formula featuring Methylene Blue and Liposomal Creatine to support mitochondrial function, skin barrier health, and resilient, hydrated skin. Click HERE and use code NAT10 to save on C.A.R.E. Mitochondrial Moisturizer.

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Dr. Bill Lawrence Episode

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Most people think that if they can just find the right mold test, they'll finally have their answer. But what if that's exactly what's keeping them stuck?

In this episode, I'm joined once again by mold investigator and building health expert Jason Earle, and we challenge some of the biggest assumptions surrounding mold illness. We unpack why modern homes may be working against our health, why the building itself should be viewed as part of your wellness ecosystem, and why one test can never tell the whole story.

If you've been dealing with unexplained symptoms, wondering whether your home could be part of the equation, or simply want to create a healthier environment for yourself and your family, this conversation will completely change the way you think about the place you call home.

Visit https://www.gotmold.com/ and use the code Nat10.

Dust test link: https://dusttest.gotmold.com/

E-Book - https://www.gotmold.com/ebook-landing-page/

Article he mentioned: https://www.gotmold.com/testing-for-mold-avoid-ermi/?srsltid=AfmBOor_h1U3x5pZnPnHZcC6V4ecKUSnXczMNBtybtaVQrSfkfIHfBPE

Episode Timestamps:

Introduction: Why Most Mold Tests Miss the Real Problem ... 00:00:00

Why Modern Homes Can Become Health Hazards ... 00:13:00

How Modern Construction Created Health Problems ... 00:17:22

The First Warning Signs Your Home May Be Making You Sick ... 00:21:30

Mold, VOCs & Why New Homes Aren't Always Safer ... 00:24:48

Construction Mistakes That Trap Moisture Inside Walls ... 00:25:37

Why You Should Build a Relationship With Your Home ... 00:28:57

The Dangerous Search for a Single "Perfect" Mold Test ... 00:29:54

What a Proper Mold Assessment Actually Looks Like ... 00:30:35

Why ERMI Can Create False Confidence or Unnecessary Panic ... 00:33:55

Petri Dish Tests: Why Jason Calls Them Junk Science ... 00:35:31

How Outdoor vs. Indoor Mold Should Really Be Compared ... 00:36:56

The Problems With ERMI's Original Design ... 00:39:18

Introducing AI-Powered Dust Testing & the Future of Mold Detection ... 00:44:00

Air Testing vs. Dust Testing: When Each Matters ... 00:46:37

Why Dust Creates a Historical Record of Your Home ... 00:48:42

When Symptoms and Test Results Don't Agree ... 00:51:00

The Nervous System's Role in Mold Illness ... 00:53:17

Confirmation Bias in Mold Testing & Functional Medicine ... 00:57:32

The Most Important Steps for Recovery ... 00:59:24

Our Amazing Sponsors:

MitoBlue by Wizard Sciences – A longevity-focused formula that combines pharmaceutical-grade methylene blue with NMN, PQQ, fisetin, and apigenin to support healthy mitochondria, cellular renewal, and healthy aging. Learn more HERE and use code NAT15 for 15% off.

Mitopure Gummies by Timeline – Supports healthier cellular energy, muscle strength, recovery, and healthy aging with clinically proven Urolithin A—without artificial sweeteners, colors, flavors, or unnecessary fillers. Head to timeline.com/nat20 to get Mitopure starting at just $99 and save an additional 20% on your order.

MassZymes by BIOptimizers - A full-spectrum digestive enzyme formula with 4x more protease than leading competitors to help maximize protein digestion and nutrient absorption. Visit bioptimizers.com/bionat and use code BIONAT for 15% off your order plus a free travel-size bottle of MassZymes while supplies last.

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Dr. Bill Lawrence Episode

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For years we've talked about longevity as if the answer is hiding in the next supplement, biomarker, or miracle molecule. But what if we've been looking at aging through far too narrow a lens? Today's guest, Dr. Marios Kyriazis, has spent decades challenging that idea by exploring aging through medicine, complexity science, cybernetics, and even philosophy.

We unpack what bioregulators actually are, why so much of the conversation around them has become overhyped, and how concepts like hormesis, adaptation, and even our relationship with technology may shape how we age. This is one of those conversations that starts with peptides and ends with a much bigger question: what does it really mean to build a longer, healthier life?

Where to find Bioregulators: visit https://profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order

Episode Timestamps:

Introduction to Dr. Marios Kyriazis & Rethinking Aging ... 00:00:00

Why Humans Age Differently Than Animals ... 00:06:49

The Role Of Consciousness, Stress & Positive Thinking ... 00:13:19

What Peptide Bioregulators Actually Are ... 00:15:29

Manufacturing, Quality Control & Why Source Matters ... 00:18:24

Carnosine, Natural Extracts & The Origins Of Bioregulators ... 00:19:48

Organ Extracts, Food & Ancient Healing Traditions ... 00:23:20

Natural vs. Synthetic Bioregulators ... 00:26:19

Personalized Medicine & Why One Size Doesn't Fit All ... 00:30:00

Side Effects, Safety & Clinical Experience ... 00:37:01

Professor Cavinson's Research: Why The West Remains Skeptical ... 00:38:32

The Biggest Misconceptions About Bioregulators ... 00:44:22

Cycling Bioregulators & The Principle Of Hormesis ... 00:47:47

How Many Bioregulators Should You Take? ... 00:50:10

Oxidative Stress, Free Radicals & Aging ... 00:51:45

Do Bioregulators Reduce Oxidative Damage? ... 00:54:37

Why Quality Manufacturing Is So Difficult ... 00:57:12

Avoiding Routine As A Longevity Strategy ... 01:07:42

Practical Longevity Advice For Midlife ... 01:11:07

Our Amazing Sponsors:

Blue Cannatine by Troscriptions – Precision-formulated troches designed to support sustained focus and mental clarity, helping you stay sharp through long workdays, recording sessions, travel, and everything in between. Visit troscriptions.com/NATPODCAST or use code NATPODCAST at checkout to save 10% off your first order.

Quantum Upgrade – A 24/7 quantum energy streaming service designed to support energy, focus, sleep, recovery, and a more balanced nervous system, backed by placebo-controlled research showing measurable improvements in stress-related brain activity and heart rate variability. Try it free for 15 days with no credit card required at QuantumUpgrade.io and use code NAT15. 

Just Thrive 90-Day Probiotic – A spore-based probiotic that survives stomach acid to arrive 100% alive in your gut, supporting better digestion, nutrient absorption, immunity, and less bloating. Start your first 90-day subscription today and you'll get a FREE 90-day supply of Digestive Bitters (a $90 value) to help optimize digestion and support healthy appetite regulation. Click HERE to learn more.

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Dr. Bill Lawrence Episode

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If you've been hearing everyone talk about exosomes but still aren't exactly sure what they are—or whether they're actually worth the hype—this episode is for you. Today I'm joined once again by Amitay Eshel and Anastasia Khodzhaeva from Young Goose to separate the science from the marketing and unpack what exosomes are really doing inside your skin.
We explore why your skin may be the most honest reflection of your biological age, how mitochondrial health and cellular repair influence the way you age, and why not all exosome products are created equal. We also get into the future of longevity skincare, formulation science, and what consumers should actually be looking for before spending money on the latest trend.
Special Young Goose Offer: Click HERE and use code NAT10 to save on Young Goose products!
Links to previous episode:
#381: Better Than Lasers: NAD+, Spermidine, and Methylene Blue for Youthful Skin | Amitay Eshel and Anastasia Khodzhaeva
#209: How to Reverse The Aging Process Without Long Term Damage with Amitay Eshel
#118: Our Skin is a Mirror: Why Skin Health is a Marker of Overall Health
#71: How to Boost the Effects of Anti-Aging Skincare and Light Therapy
Episode Timestamps:
Introduction & Returning Guests ... 00:00:00
Why Skin May Be Your Most Honest Longevity Biomarker ... 00:08:52
Gut Health, Mitochondria & What Your Skin Reveals ... 00:14:15
Biological Age vs Chronological Age ... 00:19:08
Performance, Longevity & Resilience: Three Ways to Think About Aging ... 00:21:34
The Exosome Revolution: What Are Exosomes? ... 00:30:18
Why Most Consumers Ask the Wrong Questions About Exosomes ... 00:34:08
Platelet vs Stem Cell Exosomes Explained ... 00:38:03
Why Formulation Matters More Than Marketing ... 00:43:51
How Young Goose Built Their Exosome Formula ... 00:52:28
Formulation Science vs The Next "Miracle Ingredient" ... 00:59:21
Where Longevity Skincare Is Headed Next ... 01:08:48
Final Thoughts & Young Goose Discount Code ... 01:14:06
Our Amazing Sponsors:
Manukora Honey – A delicious real-food source of prebiotics, Manukora's high-MGO Manuka honey helps support your gut microbiome, digestion, and immune health with just one teaspoon a day. Head to MANUKORA.com/NAT to save up to 31% plus receive $25 worth of free gifts with the Starter Kit.
Electrolyze by BEAM Minerals - Electrolyze is a plant-based fulvic mineral formula that delivers a full spectrum of highly bioavailable trace minerals and electrolytes to support hydration, nutrient delivery, and cellular energy. Head to beamminerals.com/NAT20, use code NAT20, and get 20% off your first order.
Grass-Fed Whey Protein by Puori - A third-party tested, grass-fed whey protein delivering 21g of protein per serving, with every batch tested for over 200 contaminants and results available via a QR code for complete transparency. Head to puori.com/nat and use code NAT20 to get 32% off your first subscription order, plus a free premium shaker bottle.
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Dr. Bill Lawrence Episode

📍 Please don’t forget to follow my NEW Instagram account at https://www.instagram.com/longevitywithnat/

Today, I’m joined by the insightful Dr. Scott Sherr, a pioneer in health optimization and mitochondrial medicine. In our conversation, Dr. Sherr introduces his groundbreaking concept—the "sympathetic spiral of doom"—and explains why so many high performers end up burned out, frustrated, and feeling like their nervous systems are working against them.

Give it a try at https://troscriptions.com/NATPODCAST or enter NATPODCAST at checkout for 10% off. Cannot be combined with any other offers.

Episode Timestamps:

Welcome and Introduction ... 00:00:00

Dr. Scott Sherr and the "Sympathetic Spiral of Doom" ... 00:00:42

Aging, Stem Cells, and Repair Strategies ... 00:01:21

Defining and Observing the Spiral in Practice ... 00:05:07

Mitochondrial Dysfunction and Chronic Stress ... 00:08:11

Why Rebuilding Energy Must Come First ... 00:12:00

High Performers, Burnout, and Overdoing Recovery ... 00:15:14

Symptoms and Effects of Burnout ... 00:16:30

Evaluating Energy, Metabolic Health, and Daily Stress ... 00:18:25

Methylene Blue: Immediate Mitochondrial Support ... 00:20:54

Clarifying: Not Stimulants, True Cellular Support ... 00:14:07

Differentiating Healthy Stress from System Overload ... 00:24:06

Oscillation Between Stress and Recovery ... 00:25:10

Signs You're Stuck in Chronic Sympathetic Mode ... 00:29:01

Sequence for Recovery: Energy, GABA, Immune, Sleep ... 00:54:06

Recognizing Progress and Returning to Capacity ... 01:00:44

Key Considerations for Methylene Blue ... 01:09:50

Anti-Aging, Recovery, and the Parasympathetic Edge ... 01:14:14

Our Amazing Sponsors:

Stemregen - A daily formula designed to support your body’s natural repair systems by helping release your own stem cells into circulation, supporting recovery, resilience, and whole-body renewal at the source. Visit stemregen.co/NAT15 and use code NAT15. 

MassZymes by BIOptimizers - A full-spectrum digestive enzyme formula with 4x more protease than leading competitors to help break down protein more efficiently so your body can actually use the amino acids you're eating. Head to bioptimizers.com/bionat and use code BIONAT for 15% off your order plus a free travel-size bottle of MassZymes (a $20 value) while supplies last.

Vita Zero-Age Exosomes by Vitali Skincare — a regenerative “stacking” formula with exosomes, GHK-Cu, niacinamide, and glutathione designed to support your skin at a cellular level rather than just the surface; go to www.vitaliskincare.com/?ref=Nat20 and use code NAT20 for 20% off.

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Dr. Bill Lawrence Episode