🎗️ In this episode lets examine the rising incidence of breast cancer in women under 40, a topic that resonates personally due to my family history, including my mother’s diagnosis and multiple relatives affected.
📊 We cover incidence and mortality trends, then systematically unpack core risk factors including genetics (BRCA1/BRCA2 and other high penetrance genes), family history, reproductive and hormonal influences, oral contraceptive use, and established lifestyle contributors.
🧬 We discuss the benefits, limitations, and considerations of screening modalities, including mammography, ultrasound, and MRI in younger populations, weighing radiation exposure against sensitivity. I also outline recommendations for genetic risk assessment and testing pathways with region-specific resources:
Australia: Breast and Ovarian Cancer Risk Management Initiative (BOCRMI) and clinical genetics through state-based services.
New Zealand: Referrals via Te Whatu Ora clinical genetics services for BRCA testing pathways.
UK/Europe: NHS Genetics Services (UK) and European Reference Networks for hereditary cancer syndromes.
Canada: Genetics/Genomics Ontario or provincial cancer genetics programs.
USA: National Society of Genetic Counselors and clinical testing through accredited labs (e.g., Myriad, Invitae) with referral from genetics professionals.
🌿 The episode outlines modifiable risk reduction strategies backed by the literature, including structured physical activity, reducing alcohol intake, enhancing metabolic and insulin sensitivity, optimising sleep quality, and dietary patterns associated with lower breast cancer risk such as Mediterranean-style diets, high fibre intake, omega-3 fatty acids, phytoestrogens (e.g., soy), and adequate vitamin D status.
Sources
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Australian Institute of Health and Welfare. (2024, June 17). Overweight and obesity: Summary. https://www.aihw.gov.au/reports/overweight-obesity/overweight-and-obesity/contents/summary
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